Analysis of transcription factor that regulates intelectin-1 expression in mesothelioma

• Project/Area Number: 26460692
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Kanagawa Cancer Center Research Institute
• Principal Investigator: Tsuji Shoutaro 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 主任研究員 (30285192)
• Research Collaborator: WASHIMI KOTA 地方独立行政法人神奈川県立病院機構, 神奈川県立がんセンター(臨床研究所)・その他部局, 医師 (30716733) ; IMAI KOHZOH 地方独立行政法人神奈川県立病院機構, 神奈川県立がんセンター(臨床研究所)・その他部局, 顧問 (60117603) ; MATSUURA RIEKO 地方独立行政法人神奈川県立病院機構, 神奈川県立がんセンター(臨床研究所)・がん治療学部, 研究補助員
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 中皮腫 / インテレクチン

Outline of Final Research Achievements

In this study, we found a new highly specific and sensitive marker for mesothelioma, HEG1. The specificity (99%) and sensitivity (92%) of HEG1 to mesothelioma were higher than those of other mesothelioma markers, containing intelectin-1. We also found that gene silencing of HEG1 significantly suppressed proliferation of mesothelioma cells; this result suggested that HEG1 was associated with oncogenesis or proliferation of mesothelioma cells. Results of this study can contribute to the improvement of pathologic diagnosis and the development of medical treatment for mesothelioma.

Research Products

• [Journal Article] HEG1 is a novel mucin-like membrane protein that serves as a diagnostic and therapeutic target for malignant mesothelioma. (2017)
  • Author(s): Shoutaro Tsuji, Kota Washimi, Taihei Kageyama, Makiko Yamashita, Rieko Matsuura, Tomoyuki Yokose, Yoichi Kameda, Hiroyuki Hayashi, Takao Morohoshi, Yukio Tsuura, Toshikazu Yusa, Takashi Sato, Hisashi Narimatsu, Yasuhiro Moriwaki, Hidemi Misawa, Kenzo Hiroshima, Yohei Miyagi, and Kohzoh Imai, et al.
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 45768-45768
  • DOI: 10.1038/srep45768
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 極めて優れた特異度と感度をしめす新規中皮腫マーカー分子の同定 (2016)
  • Author(s): 辻 祥太郎, 今井 浩三
  • Organizer: 第36回日本分子腫瘍マーカー研究会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
• [Presentation] 新規中皮腫マーカー分子の同定 (2016)
  • Author(s): 辻 祥太郎, 松浦 利絵子, 今井 浩三
  • Organizer: 第7回Japan Mesothelioma Interest Group研究会
  • Place of Presentation: JPタワー名古屋ホール＆カンファランス（愛知県名古屋市）
• [Remarks] 中皮腫の的確な診断に有用な新しい中皮腫がんマーカーを同定
  • URL: http://kcch.kanagawa-pho.jp/kccri/aboutus/files/ronbun170425.pdf
• [Remarks] 神奈川県立がんセンター臨床研究所・がん治療学部
  • URL: http://kcch.kanagawa-pho.jp/kccri/organization/chiryou.html
• [Patent(Industrial Property Rights)] 膜型ムチン様タンパク質の認識とその医療応用 (2017)
  • Inventor(s): 辻祥太郎,影山泰平,鷲見公太,辻真紀子,今井浩三ほか
  • Industrial Property Rights Holder: 地方独立行政法人神奈川県立病院機構, 国立大学法人東京大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017-01-16
  • Overseas