| Project/Area Number |
26460692
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kanagawa Cancer Center Research Institute |
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Principal Investigator |
Tsuji Shoutaro 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 主任研究員 (30285192)
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| Research Collaborator |
WASHIMI KOTA 地方独立行政法人神奈川県立病院機構, 神奈川県立がんセンター(臨床研究所)・その他部局, 医師 (30716733)
IMAI KOHZOH 地方独立行政法人神奈川県立病院機構, 神奈川県立がんセンター(臨床研究所)・その他部局, 顧問 (60117603)
MATSUURA RIEKO 地方独立行政法人神奈川県立病院機構, 神奈川県立がんセンター(臨床研究所)・がん治療学部, 研究補助員
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 中皮腫 / インテレクチン |
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| Outline of Final Research Achievements |
In this study, we found a new highly specific and sensitive marker for mesothelioma, HEG1. The specificity (99%) and sensitivity (92%) of HEG1 to mesothelioma were higher than those of other mesothelioma markers, containing intelectin-1. We also found that gene silencing of HEG1 significantly suppressed proliferation of mesothelioma cells; this result suggested that HEG1 was associated with oncogenesis or proliferation of mesothelioma cells. Results of this study can contribute to the improvement of pathologic diagnosis and the development of medical treatment for mesothelioma.
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