Research Project
Grant-in-Aid for Scientific Research (C)
In this study, we investigated functional changes in anterior cingulate cortex (ACC) of sciatic nerve ligation model mice using biochemical and electrophysiological technique. Spot patterns of the left and the right side of ACC in day 28 after nerve ligation were not same from the result of two-dimensional electrophoresis. These spots included CRMP-2 from the result of mass spectrometry analysis. However, the level of expression of CRMP-2 and pCRMP-2 were not changed between left side and right side of ACC in Western blot analysis. In addition, peak current of mIPSC in fear conditioning rats tended to decrease compared to control rats, whereas the current was not difference between left side and right side in layer II ~ III of pyramidal neuron in ACC. It is possible that excitatory transmission in ACC may be easy to occur by inhibitory system declined in chronic pain and stress condition.
All 2017 2016 2015 2014
All Journal Article (6 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 6 results, Acknowledgement Compliant: 3 results, Open Access: 3 results) Presentation (5 results)
Mol Pain
Volume: 印刷中
Mol Pharmacol
Volume: 90 Pages: 116-126
Behavioural brain research
Volume: 297 Pages: 251-258
10.1016/j.bbr.2015.10.023
Leuk Res.
Volume: 41 Pages: 103-103
10.1016/j.leukres.2015.12.008
Neuroscience research
Volume: 100 Pages: 46-54
10.1016/j.neures.2015.06.003
Neurobiology of Disease
Volume: 64 Pages: 142-9
10.1016/j.nbd.2013.12.014