Antipruritus effect and antinociceptive effect of kappa opioid at the spinal level
Project/Area Number |
26460697
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pain science
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Research Institution | Shimane University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
齊藤 洋司 島根大学, 医学部, 教授 (50162243)
|
Research Collaborator |
Sakakihara Manabu 松江赤十字病院, 麻酔科
hattori Mai 島根大学, 医学部麻酔科学講座, 技術職員
|
Project Period (FY) |
2014-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | κオピオイド受容体 / 鎮痒 / 鎮痛 / 痒み / オピオイド / κオピオイド受容体作動薬 / 術後痛 / 脊髄くも膜下腔 / モルヒネ / kappaオピオイド受容体作動薬 / 副作用 |
Outline of Final Research Achievements |
The μ-opioid receptor (MOR) agonistinduced-itch is a serious adverse effect.We demonstrated that intrathecal κ-opioid receptor agonists(KOR) exert antipruritic effects on morphine-induced itch without affecting sedation in mice.The combination of intratheca morphine and intratheca KOR agonists produces more potent antinociceptive effects against a thermal stimulus compared with morphine alone. We evaluated the effect of intraoperative pentazocine on the incidence of opioid-induced pruritus within the first 24 hours after administration of neuraxial opioids after cesarean delivery.Pentazocine reduced the overall incidence of pruritus within the first 24 hours.Pentazocine also reduced the severity of pruritus.Pentazocine after delivery can reduce both the incidence and severity of pruritus in women who have received it opioids during cesarean delivery.
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Report
(5 results)
Research Products
(10 results)