Acidosis induced pain and mechanisms of joint destruction
Project/Area Number |
26460698
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pain science
|
Research Institution | Kochi University |
Principal Investigator |
IKEUCHI Masahiko 高知大学, 教育研究部医療学系臨床医学部門, 教授 (00372730)
|
Research Collaborator |
KATHLEEN Sluka アイオワ大学, 理学療法科, 教授
IZUMI Masashi 高知大学, 教育研究部医療学系臨床医学部門, 助教
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 関節痛 / 酸感知機構 / 変形性関節症 / 関節炎 / 酸 / アシドーシス / 中枢感作 |
Outline of Final Research Achievements |
Our research is aimed to develop new drugs for the treatment of joint diseases, focusing on acidity in synovial fluid. The role of pH sensors in neurons and joint tissues were evaluated in acid induced osteoarthritis model. The results showed that ASIC3, one of pH sensors, was essential for inducing widespread long-lasting hyperalgesia and joint destruction.
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Report
(4 results)
Research Products
(7 results)
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[Presentation] 関節痛と神経機能変化2016
Author(s)
池内昌彦
Organizer
第31回日本整形外科学会基礎学術集会
Place of Presentation
福岡国際会議場(福岡県福岡市)
Year and Date
2016-10-14
Related Report
Invited
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[Presentation] 変形性膝関節症の病態と痛み2016
Author(s)
池内昌彦
Organizer
第127回中部日本整形外科災害外科学会学術集会
Place of Presentation
まつもと市民芸術館(長野県松本市)
Year and Date
2016-10-01
Related Report
Invited
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