Elucidation of the spinal monoamine dynamics in the diabetic neuropathy by spinal cord stimulation
| Project/Area Number |
26460701
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Osaka City University |
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Principal Investigator |
FUNAO TOMOHARU 大阪市立大学, 大学院医学研究科, 講師 (70433307)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 糖尿病性神経障害 / 脊髄刺激療法 / 神経アミノ酸 |
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| Outline of Final Research Achievements |
We investigated the movement of monoamine and amino acid in the spinal dorsal horn in rats with diabetic mellitus by spinal cord stimulation(SCS). The concentration of monoamine and amino acid in the spinal dorsal horn was not changed by SCS, also in the striatum was not changed. In free-moving diabetic neuropthy rats, the result was same. Our results cannot prove that the analgesic mechanism of SCS for diabetic neuropathy is involved with monoamine and amino acid in the spinal dorsal horn and the striatum.
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Report
(4 results)
Research Products
(8 results)
