Elucidation of the spinal monoamine dynamics in the diabetic neuropathy by spinal cord stimulation

• Project/Area Number: 26460701
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pain science
• Research Institution: Osaka City University
• Principal Investigator: FUNAO TOMOHARU 大阪市立大学, 大学院医学研究科, 講師 (70433307)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 糖尿病性神経障害 / 脊髄刺激療法 / 神経アミノ酸

Outline of Final Research Achievements

We investigated the movement of monoamine and amino acid in the spinal dorsal horn in rats with diabetic mellitus by spinal cord stimulation(SCS). The concentration of monoamine and amino acid in the spinal dorsal horn was not changed by SCS, also in the striatum was not changed. In free-moving diabetic neuropthy rats, the result was same. Our results cannot prove that the analgesic mechanism of SCS for diabetic neuropathy is involved with monoamine and amino acid in the spinal dorsal horn and the striatum.

Research Products

• [Journal Article] Transcutaneous near-infrared spectroscopy for monitoring spinal cord ischemia: an experimental study in swine (2016)
  • Author(s): Koichi Suehiro, Tomoharu Funao, Yohei Fujimoto, Akira Mukai, Mitsuyo Nakamura, Kiyonobu Nishikawa
  • Journal Title: Journal of Clinical Monitoring and Computing Volume: 27 Issue: 5 Pages: 1-5
  • DOI: 10.1007/s10877-016-9931-8
  • Peer Reviewed
• [Journal Article] Brain serotonin content regulates the manifestation of tramadol-induced seizures in rats: disparity between tramadol-induced seizure and serotonin syndrome. (2015)
  • Author(s): Yohei Fujimoto, Tomoharu Funao, Koichi Suehiro, Ryota Takahashi, Takashi Mori, Kiyonobu Nishikawa
  • Journal Title: Anesthesiology Volume: 122 Issue: 1 Pages: 178-189
  • DOI: 10.1097/aln.0000000000000434
  • Peer Reviewed / Open Access
• [Journal Article] Discrepancy Between Superior Vena Cava Oxygen Saturation and Mixed Venous Oxygen Saturation Can Predict Postoperative Complications in Cardiac Surgery Patients. (2014)
  • Author(s): Koichi Suehiro, Katsuaki Tanaka, Tadashi Matsuura, Tomoharu Funao, Tokuhiro Yamada, Takashi Mori, Kiyonobu Nishikawa
  • Journal Title: Journal of Cardiothorathic and Vascular Anesthesia Volume: 28（３） Issue: 3 Pages: 528-533
  • DOI: 10.1053/j.jvca.2013.03.002
  • Peer Reviewed
• [Journal Article] Use of Tricyclic Antidepressants as Analgesic Adjuvants Results in Nonhazardous Prolongation of the QTc Interval (2014)
  • Author(s): Yusuke Funai, Tomoharu Funao, Kazutake Ikenaga, Ryota Takahashi, Ichiro Hase, Kiyonobu Nishikawa
  • Journal Title: Osaka City Medical Journal Volume: 60(1) Pages: 11-19
  • NAID: 120006493304
  • Peer Reviewed
• [Journal Article] Preoperative hydroperoxide concentrations are associated with a risk of postoperative complications after cardiac surgery. (2014)
  • Author(s): Koichi Suehiro, Katsuaki Tanaka, Tadashi Matsuura, Tomoharu Funao, Tokuhiro Yamada, Takashi Mori, Masahiko Tsuchiya, Kiyonobu Nishikawa
  • Journal Title: Anaesthesia and Intensive Care Volume: 42(4) Pages: 487-494
  • Peer Reviewed
• [Presentation] Transcutaneous Near-infared Spectroscopy for Monitoring Spinal Cord Circulation: An Experimental Study (2015)
  • Author(s): Koichi Suehiro, Tomoharu Funao, Yohei Fujimoto, Mitsuyo Nakamura, Kiyonobu Nishikawa
  • Organizer: 2015 Annual Meeting, American Society of Anesthesiologists
  • Place of Presentation: サンディエゴ(アメリカ合衆国)
  • Year and Date: 2015-10-24
  • Int'l Joint Research
• [Presentation] The reliability of three-dimentional transesophageal echocardiography in measuring cardiac output. (2014)
  • Author(s): Koichi Suehiro, Katsuaki Tanaka, Tadashi Matsuura, Tomoharu Funao, Tokuhiro Yamada, Takashi Mori, Kiyonobu Nishikawa
  • Organizer: 2014 Annual Meeting, American Society of Anesthesiologists
  • Place of Presentation: New Orleans, Louisiana, USA
  • Year and Date: 2014-10-16 – 2014-10-19
• [Presentation] Improved performance of the new Vigileo-Flotrack system (Version 4.00) for tracking cardiac output changes. (2014)
  • Author(s): Koichi Suehiro, Katsuaki Tanaka, Tadashi Matsuura, Tomoharu Funao, Tokuhiro Yamada, Takashi Mori, Kiyonobu Nishikawa
  • Organizer: 2014 Annual Meeting, American Society of Anesthesiologists
  • Place of Presentation: New Orleans, Louisiana, USA
  • Year and Date: 2014-10-16 – 2014-10-19