Elucidation of pain control mechanism via sodium channel of novel target molecule contained in herbal medicine Goshajinkigan
| Project/Area Number |
26460703
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | International University of Health and Welfare |
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Principal Investigator |
AMANO TAKU 国際医療福祉大学, 薬学部, 教授 (10294547)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKATANI YOSHIHIKO 国際医療福祉大学, 薬学部, 助教 (40582169)
SAKAKIBARA IWAO 日本薬科大学, 薬学部, 教授 (50581972)
YAHAGI TADAHIRO 日本大学, 薬学部, 助教 (40632766)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 牛車腎気丸 / 六味丸 / 疼痛 / 電気生理 / ナトリウムチャネル / 附子末 / 電気生理学 / 痛み / 漢方 / パッチクランプ / ブシ末 |
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| Outline of Final Research Achievements |
Goshajinkigan, one of the traditional Japanese Kampo formulas, has been used for neuropathic pain. However, how goshajinkigan suppresses the neuropathic pain are still unclear. In this study, we investigated the effect of Goshajinkigan and those ingredients to the voltage-gated sodium channels current (VGSCs) of Nav1.7 which predominantly expresses in peripheral nerve, particularly dorsal root ganglion using HEK293 cells expressing human Nav1.7 VGSCs. Our finding suggested that goshajinkigan may exhibit suppression of the neuropathic pain via Nav1.7 Na+ current inhibition by multiple components included in goshajinkigan.
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Report
(5 results)
Research Products
(13 results)
