| Project/Area Number |
26460705
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
石橋 仁 北里大学, 医療衛生学部, 教授 (50311874)
歌 大介 富山大学, 大学院医学薬学研究部(薬学), 助教 (70598416)
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| Co-Investigator(Renkei-kenkyūsha) |
Noda Kazuko 北里大学, 医療衛生学部, 講師 (60050704)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 幼若期ドーパミン神経系傷害 / 痒み感覚 / 体性感覚系の発達 / ドーパミン神経系 / ドーパミン神経系傷害 / ミクログリアの活性化 / ドーパミン神経傷害 / 痒覚 / 行動実験 / c-Fos |
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| Outline of Final Research Achievements |
The aim of this study is to clarify the effects of neonatal dopamine (DA) depletion on itch-related responses during the adulthood using behavioral, histological and electrophysiological methods. Serotonin (5-TH) was injected into middle plantar region of the hid paw, as an itch-inducing substance. The results indicated that neonatal DA depletion caused significant decrease in number of itch-related behavior during the adulthood, but no change in threshold of 5-HT for the inducing itch-related behavior. In the histological and electrophysiological analyses, the spinal neurons that responded to the 5-HT injected into the hid paw were located in the superficial layer (laminae I-II), and the neonatal DA depletion did not affect the responsibility to the 5-HT in the spinal neurons.
These results indicated that dopaminergic neural system play a crucial part in development of mechanism for itch sensation.
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