| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Many reports suggest that multiple G protein-coupled receptor (GPCR)s form heteromeric complexes and cooperatively trigger atypical signaling that cannot be initiated by individual GPCRs on their own. Indeed, previous studies suggest that Adenosine A1 receptor (A1R) activation also modulates cellular responses that depend on type-1 metabotropic glutamate receptor (mGluR1). mGluR1 are involved in pain transmission and synaptic plasticity including cerebellar long-term depression (LTD). In this project, we indicated that mGluR1-A1R form heteromeric complex and these receptors mutually modulate each other by direct interaction. These findings indicate a new mechanism of cooperation between neuronal GPCRs to elicit atypical and intriguing cellular responses.
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