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Association between mitochondria quality control and chronic pain by NIPSNAP1

Research Project

Project/Area Number 26460709
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pain science
Research InstitutionOsaka Institute of Technology

Principal Investigator

ASHITAKA Emiko  大阪工業大学, 工学部, 教授 (50291802)

Co-Investigator(Kenkyū-buntansha) 伊藤 誠二  関西医科大学, 医学部, 教授 (80201325)
Co-Investigator(Renkei-kenkyūsha) OHMIYA Yoshihiro  産業技術総合研究所, バイオメディカル研究部門, 部門長 (20223951)
Research Collaborator OKAMOTO Kazuya  大阪工業大学, 大学院工学研究科, 大学院生
OHNO Kana  大阪工業大学, 大学院工学研究科, 大学院生
KAWABATA Kenta  大阪工業大学, 大学院工学研究科, 大学院生
MATSUOKA Etsuko  大阪工業大学, 大学院工学研究科, 大学院生
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsNIPSNAP1 / ミトコンドリア / マイトファジー / 炎症性疼痛 / 糖尿病性神経因性疼痛 / 一酸化窒素 / 遺伝子発現
Outline of Final Research Achievements

4-Nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog (NIPSNAP) 1 is expressed in the synaptic membrane and the mitochondria. Synaptic NIPSNAP1, which interacts with the neuropeptide nocistatin, has been implicated in the inhibition of tactile pain allodynia. Here, we investigated the involvement of NIPSNAP1 in the mitochondrial functions in the dorsal root ganglion neurons prepared from NIPSNAP1-deficient mice. We revealed that NIPSNAP1 is involved in the regulation of reactive oxygen species production and the autophagy of the mitochondria in dorsal root ganglion neurons.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (16 results)

All 2017 2016 2015 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (11 results) (of which Int'l Joint Research: 4 results) Remarks (2 results)

  • [Journal Article] 糖尿病性神経因性疼痛の分子メカニズム2017

    • Author(s)
      芦高恵美子
    • Journal Title

      BIO Clinica

      Volume: 32 Pages: 75-77

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Involvement of NIPSNAP1, a neuropeptide nocistatin-interacting protein, in inflammatory pain.2016

    • Author(s)
      Okamoto K, Ohashi M, Ohno K, Takeuchi A, Matsuoka E, Fujisato K, Minami T, Ito S, Okuda-Ashitaka E.
    • Journal Title

      Mol. Pain

      Volume: 12 Pages: 1-11

    • DOI

      10.1177/1744806916637699

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Intrathecal administration of low-dose nociceptin/orphanin FQ induces allodynia via c-Jun N-terminal kinase and monocyte chemoattractant protein-1.2016

    • Author(s)
      Kawabata K, Nishimura I, Fujiwara T, Terauchi S, Minami T, Ito S, Okuda-Ashitaka E.
    • Journal Title

      Eur. J. Neurosci.

      Volume: 印刷中 Issue: 11 Pages: 1499-1508

    • DOI

      10.1111/ejn.13247

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Mitochondrial functions of 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 in mouse dorsal root ganglion neurons2017

    • Author(s)
      Emiko Okuda-Ashitaka, Etsuko Matsuoka, Izuru Ohtsu, Yuji Yano
    • Organizer
      Society for Neuroscience, The 47th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      ワシントンDC(米国)
    • Year and Date
      2017-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マウス脊髄と後根神経節におけるノシスタチン結合分子NIPSNAP1によるミトコンドリ アの機能解析2016

    • Author(s)
      松岡悦子, 矢野裕士, 大津出, 鍵本真人, 安永俊之, 松井凌介, 坂元秀幸, 芦高恵美子
    • Organizer
      日本分子生物学会, 第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] Nociceptin/Orphanin FQ-induced allodynia via c-Jun N-terminal kinase and monocyte chemoattractant protein-1 in the spinal cord2016

    • Author(s)
      Emiko Okuda-Ashitaka, Kenta Kawabata, Isamu Nishimura, Takeshi Fujiwara, Shoko Terauchi, Toshiaki Minami, Seiji Ito
    • Organizer
      International Association for the Study of Pain, 16th World Congress on Pain
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-09-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] JNKの活性化によるMCP-1遊離を介したノシセプチンのアロディニア発症2015

    • Author(s)
      川端健太、藤原武史、西村勇武、寺内祥子、南敏明、伊藤誠二、芦高恵美子
    • Organizer
      日本生化学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-12-02
    • Related Report
      2015 Research-status Report
  • [Presentation] 一酸化窒素を介した糖尿病性神経因性疼痛の中枢性感作2015

    • Author(s)
      大野華奈、安永俊之、芦高恵美子
    • Organizer
      日本生化学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-12-02
    • Related Report
      2015 Research-status Report
  • [Presentation] Expression change of NIPSNAP1, a neuropeptide nocistatin-interacting protein, following inflammatory pain2015

    • Author(s)
      Emiko Okuda-Ashitaka, Kazuya Okamoto, Masaki Ohashi , Kana Ohno, Toshiaki Minami, Seiji Ito
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      シカゴ(米国)
    • Year and Date
      2015-10-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Nociceptin/orphanin FQ receptor antagonist JTC-801 inhibits spinal nitric oxide production and neuropathic pain in diabetic mice2015

    • Author(s)
      Kana Ohno, Toshiyuki Yasunaga, Hideyuki Sakamoto, Emiko Okuda-Ashitaka
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      シカゴ(米国)
    • Year and Date
      2015-10-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ノシセプチン受容体拮抗薬による糖尿病性神経因性疼痛への効果2015

    • Author(s)
      大野華奈、安永俊之、芦高恵美子
    • Organizer
      日本生物高分子学会
    • Place of Presentation
      香川大学幸町キャンパス(香川県・高松市)
    • Year and Date
      2015-09-19
    • Related Report
      2015 Research-status Report
  • [Presentation] ノシスタチン結合分子NIPSNAP1のスプライスバリアントの細胞内局在と機能解析2015

    • Author(s)
      蒔田紗英,芦高恵美子
    • Organizer
      日本生物高分子学会
    • Place of Presentation
      香川大学幸町キャンパス(香川県・高松市)
    • Year and Date
      2015-09-19
    • Related Report
      2015 Research-status Report
  • [Presentation] 糖尿病神経因性疼痛に伴う脊髄におけるミトコンドリアの機能解析2015

    • Author(s)
      松岡悦子,大野華奈,鍵本真人,安永俊之,松井凌介,坂元秀幸,芦高恵美子
    • Organizer
      日本生化学会近畿支部例会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス(滋賀)
    • Year and Date
      2015-05-16
    • Related Report
      2014 Research-status Report
  • [Presentation] 糖尿病性神経因性疼痛に伴う脊髄後角の一酸化窒素産生制御2015

    • Author(s)
      大野華奈,安永俊之,芦高恵美子
    • Organizer
      日本生化学会近畿支部例会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス(滋賀)
    • Year and Date
      2015-05-16
    • Related Report
      2014 Research-status Report
  • [Remarks] 大阪工業大学工学部生命工学科分子生体機能学研究室ホームページ

    • URL

      http://www.oit.ac.jp/bio/labo/~ashitaka/home.html

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
  • [Remarks] 大阪工業大学工学部生命工学科分子生体機能学研究室

    • URL

      http://www.oit.ac.jp/bio/labo/~ashitaka/home.html

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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