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Application of blood/tissue boron analysis for in-hospital BNCT

Research Project

Project/Area Number 26460718
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical Physics and Radiological Technology
Research InstitutionIbaraki Prefectural University of Health Science (2016)
University of Tsukuba (2014-2015)

Principal Investigator

NAKAI KEI  茨城県立医療大学, 公私立大学の部局等, 准教授 (50436284)

Co-Investigator(Kenkyū-buntansha) 吉田 文代  筑波大学, 医学医療系, 助教 (30261811)
熊田 博明  筑波大学, 医学医療系, 准教授 (30354913)
松村 明  筑波大学, 医学医療系(副学長), 副学長 (90241819)
Co-Investigator(Renkei-kenkyūsha) SATO Takahiro  国立研究開発法人 量子化学技術研究開発機構, 高崎量子応用研究所・放射線高度利用施設部, 研究副主幹 (10370404)
KOKA Masashi  国立研究開発法人 量子化学技術研究開発機構, 高崎量子応用研究所・放射線高度利用施設部, 技術開発協力員
YAMADA Naoto  国立研究開発法人 量子化学技術研究開発機構, 高崎量子応用研究所・放射線高度利用施設部, 技術開発協力員
Research Collaborator KURITA Tadashi  
ENDO Keita  
ENDO Kiyoshi  
MIYAKAWA Makiko  
MATSUSHITA Akira  
OKAMOTO Emiko  
KITAMURA Akane  
YAMAMOTO Tetsuya  
YAMAMOTO Yohei  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsBNCT / ホウ素中性子捕捉療法 / PIXE / PIGE / 中性子捕捉療法 / 荷電粒子線放射化分析 / マイクロビーム
Outline of Final Research Achievements

Micro-PIXE/PIGE analysis was performed at Takasaki Ion Accelerators for Advanced Radiation Application. The liquid boron containing samples were measured and were able to quantitation within 10-15min. The cellular samples that attached on thin polycarbonate membranes were freeze-dried. Elements (Potassium, Phosphate, Boron) distribution images were analysed. After 800ug/mL Boron containing medium exposure, The cell image analysis showed the coresident of boron and cells. less than 300 ug/mL Boron containing medium, boron could not distinguish between boron and background. Higher sensitivity or higher resolution would be needed.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (16 results)

All 2017 2016 2015 2014

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (12 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results)

  • [Journal Article] ホウ素中性子捕捉療法に用いる新規ホウ素化合物の開発の現状2017

    • Author(s)
      中井 啓
    • Journal Title

      茨城県立医療大学紀要

      Volume: 22 Pages: 1-10

    • NAID

      40021242170

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Use of boron cluster-containing redox nanoparticles with ROS scavenging ability in  boron neutron capture therapy to achieve high therapeutic efficiency and low adverse effects.2016

    • Author(s)
      Gao Zenyu
    • Journal Title

      Biomaterials.

      Volume: 104 Pages: 201-212

    • DOI

      10.1016/j.biomaterials.2016.06.046

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Влияние нейтронного излучения на жизнеспособность опухолевых клеток, культивируемых в присутствии изотопа бора 10B (Impact of neutron radiation on the viability of tumor cells cultured in the presence of boron-10 isotope)2016

    • Author(s)
      О.Ю. Волкова, Л.В. Мечетина, А.В. Таранин, А. А. Заборонок, K. Nakai, С.И. Лежнин, С.А. Фролов, Д.А. Касатов, А.Н. Макаров, И.Н. Сорокин, Т.В. Сычева, И.М. Щудло, С.Ю. Таскаев
    • Journal Title

      Vestnik rentgenologii i radiologii

      Volume: 97 Issue: 5 Pages: 283-288

    • DOI

      10.20862/0042-4676-2016-97-5-283-288

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Boron analysis for neutron capture therapy using particle-induced gamma-ray emission2015

    • Author(s)
      Nakai K, Yamamoto Y, Okamoto E, Yamamoto T, Yoshida F, Matsumura A, Yamada N, Kitamura A, Koka M, Satoh T
    • Journal Title

      Appl Radiat Isot

      Volume: 106 Pages: 166-170

    • DOI

      10.1016/j.apradiso.2015.07.035

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Application of carbon nanohorns containing boron to BNCT2016

    • Author(s)
      K. Nakai, K Endo, A. Zaboronok, E. Sato, F. Yoshida, T. Kurita, M. Yudasaka, S. Taskaev, V. Kanygin, O. Volkova, L. Mechetina, A. Taranin, M. Koka, N. Yamada, T. Satoh, T.Yamamoto and A. Matsumura
    • Organizer
      17th International congress on neutron capture therapy
    • Place of Presentation
      ミズーリ USA
    • Year and Date
      2016-10-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Property and in vitro study of a liposome modified boron lipid for combination therapy2016

    • Author(s)
      M Shirakawa, K. Nakai, F. Yoshida, T. Ito, M Sato, T. Yamamoto, A.Matsumura,H.Tomida    Property and in vitro study of a liposome modified boron lipid for combination therapy,
    • Organizer
      17th International congress on neutron capture therapy
    • Place of Presentation
      ミズーリ USA
    • Year and Date
      2016-10-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tandem accelerator-based neutron source for boron neutron capture therapy:     in vitro efficacy evaluation with in-sample dosimetry using gold nanoparticles2016

    • Author(s)
      A. Zaboronok, S. Taskaev, K. Nakai, D. Kasatov, A. Makarov, I. Schudlo, I. Sorokin, T. Sycheva, O. Volkova, L. Mechetina, A. Taranin, A. Iarullina, V. Kanygin, V. Byvaltsev, E. Sato, T. Yamamoto, A. Matsumura
    • Organizer
      17th International congress on neutron capture therapy
    • Place of Presentation
      ミズーリ USA
    • Year and Date
      2016-10-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 筑波大学における粒子線(陽子線・BNCT)の経験と将来展望2016

    • Author(s)
      松村 明, 山本 哲哉, 中井 啓, 熊田 博明, 櫻井 英幸, 坪井 康次
    • Organizer
      日本脳神経外科学会第75回学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2016-09-29
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 大気マイクロPIXE/PIGE を用いた細胞、組織内ホウ素検出の検討2016

    • Author(s)
      遠藤圭汰、栗田 正、吉田文代、中井 啓、江夏昌志、佐藤隆博、山本哲哉
    • Organizer
      第13回日本中性子捕捉療法学会
    • Place of Presentation
      東京
    • Year and Date
      2016-08-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] micro particle induced gamma-ray emission (micro PIGE)を用いたホウ素分析の応用2015

    • Author(s)
      中井 啓、 遠藤圭汰、吉田文代、栗田正、山本陽平、江夏昌志、山田尚人、喜多村茜、佐藤隆博、山本哲哉
    • Organizer
      第12回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      神戸学院大学ポートアイランドキャンパス、神戸
    • Year and Date
      2015-09-04
    • Related Report
      2015 Research-status Report
  • [Presentation] 癌幹細胞モデルを用いたホウ素化合物の取り込みに関する検討2015

    • Author(s)
      栗田正、中井啓、吉田文代、山本哲哉、松村明
    • Organizer
      第12回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      神戸学院大学ポートアイランドキャンパス、神戸
    • Year and Date
      2015-09-04
    • Related Report
      2015 Research-status Report
  • [Presentation] Phase I/II clinical BNCT trial for Glioblastoma at JRR-42015

    • Author(s)
      Kei Nakai, Tetsuya Yamamoto, Fumiyo Yoshida, Makoto Shirakawa, Yohei Yamamoto, Hiroaki Kumada, Teruhito Aihara, Akira Matsumura, Hideyuki Sakurai
    • Organizer
      15th International Congress of Radiation Research
    • Place of Presentation
      Kyoto International Conference Center, Kyoto、Japan
    • Year and Date
      2015-05-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ➢A method for individual quantitation of the combined boronophenylalanine and borocaptate by liquid chromatography-electrospray ionization-mass spectrometry2014

    • Author(s)
      C.Bi, Y. Yamaguchi, S. Bamba, H. Kumada, K. Nakai and T. Morimoto
    • Organizer
      16th international congress of neutron capture therapy
    • Place of Presentation
      Helsinki, Finland
    • Year and Date
      2014-06-14 – 2014-06-19
    • Related Report
      2014 Research-status Report
  • [Presentation] ➢Development of rapid and precise boron isotope analysis in whole blood by HR-ICP-MS2014

    • Author(s)
      Y.Yamaguchi, C. Bi, S. Bamba, H. Kumada, K. Nakai, K. E. Yamaguchi, T.Morimoto
    • Organizer
      16th international congress of neutron capture therapy
    • Place of Presentation
      Helsinki, Finland
    • Year and Date
      2014-06-14 – 2014-06-19
    • Related Report
      2014 Research-status Report
  • [Presentation] ➢Detection of plasmid strand breaks in boron neutron capture reaction2014

    • Author(s)
      E. Okamoto, K. Nakai, F. Yoshida, M. Miyakawa, Y. Yamamoto, H. Tanaka, Y.Sakurai, S. Msunaga, T. Yamamoto, A. Matsumura
    • Organizer
      16th international congress of neutron capture therapy
    • Place of Presentation
      Helsinki, Finland
    • Year and Date
      2014-06-14 – 2014-06-19
    • Related Report
      2014 Research-status Report
  • [Presentation] ➢Application of micro-PIXE/PIGE technology to boron concentration analysis2014

    • Author(s)
      Kei Nakai, F. Yoshida, E. Okamoto, T. Sato, M. Koka, Y. Yamamoto,T.Yamamoto, A. Matsumura
    • Organizer
      16th international congress of neutron capture therapy
    • Place of Presentation
      Helsinki,Finland
    • Year and Date
      2014-06-14 – 2014-06-19
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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