Application of blood/tissue boron analysis for in-hospital BNCT
Project/Area Number |
26460718
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Medical Physics and Radiological Technology
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Research Institution | Ibaraki Prefectural University of Health Science (2016) University of Tsukuba (2014-2015) |
Principal Investigator |
NAKAI KEI 茨城県立医療大学, 公私立大学の部局等, 准教授 (50436284)
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Co-Investigator(Kenkyū-buntansha) |
吉田 文代 筑波大学, 医学医療系, 助教 (30261811)
熊田 博明 筑波大学, 医学医療系, 准教授 (30354913)
松村 明 筑波大学, 医学医療系(副学長), 副学長 (90241819)
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Co-Investigator(Renkei-kenkyūsha) |
SATO Takahiro 国立研究開発法人 量子化学技術研究開発機構, 高崎量子応用研究所・放射線高度利用施設部, 研究副主幹 (10370404)
KOKA Masashi 国立研究開発法人 量子化学技術研究開発機構, 高崎量子応用研究所・放射線高度利用施設部, 技術開発協力員
YAMADA Naoto 国立研究開発法人 量子化学技術研究開発機構, 高崎量子応用研究所・放射線高度利用施設部, 技術開発協力員
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Research Collaborator |
KURITA Tadashi
ENDO Keita
ENDO Kiyoshi
MIYAKAWA Makiko
MATSUSHITA Akira
OKAMOTO Emiko
KITAMURA Akane
YAMAMOTO Tetsuya
YAMAMOTO Yohei
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | BNCT / ホウ素中性子捕捉療法 / PIXE / PIGE / 中性子捕捉療法 / 荷電粒子線放射化分析 / マイクロビーム |
Outline of Final Research Achievements |
Micro-PIXE/PIGE analysis was performed at Takasaki Ion Accelerators for Advanced Radiation Application. The liquid boron containing samples were measured and were able to quantitation within 10-15min. The cellular samples that attached on thin polycarbonate membranes were freeze-dried. Elements (Potassium, Phosphate, Boron) distribution images were analysed. After 800ug/mL Boron containing medium exposure, The cell image analysis showed the coresident of boron and cells. less than 300 ug/mL Boron containing medium, boron could not distinguish between boron and background. Higher sensitivity or higher resolution would be needed.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Влияние нейтронного излучения на жизнеспособность опухолевых клеток, культивируемых в присутствии изотопа бора 10B (Impact of neutron radiation on the viability of tumor cells cultured in the presence of boron-10 isotope)2016
Author(s)
О.Ю. Волкова, Л.В. Мечетина, А.В. Таранин, А. А. Заборонок, K. Nakai, С.И. Лежнин, С.А. Фролов, Д.А. Касатов, А.Н. Макаров, И.Н. Сорокин, Т.В. Сычева, И.М. Щудло, С.Ю. Таскаев
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Journal Title
Vestnik rentgenologii i radiologii
Volume: 97
Issue: 5
Pages: 283-288
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Application of carbon nanohorns containing boron to BNCT2016
Author(s)
K. Nakai, K Endo, A. Zaboronok, E. Sato, F. Yoshida, T. Kurita, M. Yudasaka, S. Taskaev, V. Kanygin, O. Volkova, L. Mechetina, A. Taranin, M. Koka, N. Yamada, T. Satoh, T.Yamamoto and A. Matsumura
Organizer
17th International congress on neutron capture therapy
Place of Presentation
ミズーリ USA
Year and Date
2016-10-03
Related Report
Int'l Joint Research
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[Presentation] Tandem accelerator-based neutron source for boron neutron capture therapy: in vitro efficacy evaluation with in-sample dosimetry using gold nanoparticles2016
Author(s)
A. Zaboronok, S. Taskaev, K. Nakai, D. Kasatov, A. Makarov, I. Schudlo, I. Sorokin, T. Sycheva, O. Volkova, L. Mechetina, A. Taranin, A. Iarullina, V. Kanygin, V. Byvaltsev, E. Sato, T. Yamamoto, A. Matsumura
Organizer
17th International congress on neutron capture therapy
Place of Presentation
ミズーリ USA
Year and Date
2016-10-03
Related Report
Int'l Joint Research
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[Presentation] Phase I/II clinical BNCT trial for Glioblastoma at JRR-42015
Author(s)
Kei Nakai, Tetsuya Yamamoto, Fumiyo Yoshida, Makoto Shirakawa, Yohei Yamamoto, Hiroaki Kumada, Teruhito Aihara, Akira Matsumura, Hideyuki Sakurai
Organizer
15th International Congress of Radiation Research
Place of Presentation
Kyoto International Conference Center, Kyoto、Japan
Year and Date
2015-05-25
Related Report
Int'l Joint Research
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[Presentation] ➢Detection of plasmid strand breaks in boron neutron capture reaction2014
Author(s)
E. Okamoto, K. Nakai, F. Yoshida, M. Miyakawa, Y. Yamamoto, H. Tanaka, Y.Sakurai, S. Msunaga, T. Yamamoto, A. Matsumura
Organizer
16th international congress of neutron capture therapy
Place of Presentation
Helsinki, Finland
Year and Date
2014-06-14 – 2014-06-19
Related Report
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