Measurement of trace elements with micro-PIXE method in myeloma cells and development of novel drugs
| Project/Area Number |
26460720
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical Physics and Radiological Technology
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
神谷 富裕 群馬大学, 大学院理工学府, 教授 (70370385)
齋藤 貴之 群馬大学, 大学院保健学研究科, 教授 (80375542)
長嶺 竹明 群馬大学, その他部局等, 名誉教授 (90180520)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 多発性骨髄腫 / マイクロPIXE / 微量元素 / ボルテゾミブ / bortezomib |
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| Outline of Final Research Achievements |
We introduced an in-air micro-PIXE (micro-PIXE) method in the measurement of trace elements in cultured myeloma cells and analyzed the change of trace elements before and after the treatment with bortezomib (proteasome inhibitor) and melphalan (alkylating agent). The cells were gathered on polycarbonate film with cytocentrifuge and measured with micro-PIXE. We established the micro-PIXE method to analyze trace elements in free cultured cells. Phosphate and Calcium changed by high-dose bortezomib treatment, but not by melphalan.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Trends of survival in patients with multiple myeloma in Japan: a multicenter retrospective collaborative study of the Japanese Society of Myeloma.2015
Author(s)
Ozaki S, Handa H, Saitoh T, Murakami H, Itagaki M, Asaoku H, Suzuki K, Isoda A, Matsumoto M, Sawamura M, Konishi J, Sunami K, Takezako N, Hagiwara S, Kuroda Y, Chou T, Nagura E, Shimizu K.
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Journal Title
Blood Cancer J
Volume: 5
Issue: 9
Pages: e349-e349
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] A new staging system to predict prognosis of patients with multiple myeloma in an era of novel therapeutic agents.2014
Author(s)
Iriuchishima H, Saitoh T, Handa H, Isoda A, Matsumoto M, Sawamura M, Iwasaki A, Ushie C, Hattori H, Sasaki Y, Mitsui T, Yokohama A, Tsukamoto N, Murakami H, Nojima Y.
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Journal Title
Eur J Haematol.
Volume: 94
Issue: 2
Pages: 145-151
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Survival of Multiple Myeloma Patients Aged 65-70 Years in the Era of Novel Agents and Autologous Stem Cell Transplantation. A Multicenter Retrospective Collaborative Study of the Japanese Society of Myeloma and the European Myeloma Network.2014
Author(s)
Ozaki S, Harada T, Saitoh T, Shimazaki C, Itagaki M, Asaoku H, Kuroda Y, Chou T, Yoshiki Y, Suzuki K, Murakami H, Hayashi K, Mina R, Palumbo A, Shimizu K.
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Journal Title
Acta Haematol.
Volume: 132
Pages: 211-219
Related Report
Peer Reviewed
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[Presentation] The Polymorphism of IL-10-592 C/A is associated with high risk of myelodysplastic syndromes(MDS)2014
Author(s)
KasamatsuT, Saitoh T, Gotoh N, NittaY, Kaneko A, Suda I, Masuda Y, Norjimaa B, Takahashi N, Inoue M, Alkebsi L, Minato Y, HoshinoT, Hatsumi H, Takada S, Sakura T, Shimizu H, Ishizaki T, Takizawa M, Koiso H, Mitsui T, Yokohama A, Tsukamoto N, Handa H, Nojima Y, Murakami H.
Organizer
日本血液学会
Place of Presentation
大阪
Year and Date
2014-10-31 – 2014-11-02
Related Report
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[Presentation] Network of micro RNA and epigenetics are associated with the progression of MGUS and multiple myeloma.2014
Author(s)
Masuda Y, Handa H, Hattori H, Kaneko A, Suda I, Lobna Alkebsi, Saitoh T, Iriuchishima H, Takizawa M, Koiso H, Isoda A, Matsumoto M, Sawamura M, Tahara K, Ishizaki T, Mitsui T, Shimizu H, Yokohama A, Tsukamoto N, Nojima Y, Murakami H.
Organizer
Annual Meeting of European Hematology Association
Place of Presentation
ミラノ
Year and Date
2014-06-12 – 2014-06-15
Related Report
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[Book] 医歯薬出版2014
Author(s)
村上博和、齋藤貴之、笠松哲光
Total Pages
496
Publisher
スタンダード検査血液学第3版
Related Report
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