Fundamental detailed display and quantitative brain functional analysis research for PET

• Project/Area Number: 26460730
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical Physics and Radiological Technology
• Research Institution: Iwate Medical University
• Principal Investigator: Sasaki Toshiaki 岩手医科大学, 医学部, 助教 (20438500)
• Co-Investigator(Kenkyū-buntansha): 世良 耕一郎 岩手医科大学, 医学部, 教授 (00230855) ; 小笠原 邦昭 岩手医科大学, 医学部, 教授 (00305989) ; 米澤 久司 岩手医科大学, 医学部, 准教授 (20240377)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: PET / SUV / 分解能 / 詳細表示 / 脳血流 / アミロイド / 簡略化

Outline of Final Research Achievements

The results of the study are as follows. We evaluated the ultimate capability of the PET/CT performance using the PET/CT image reconstruction method. Although the "Japanese guideline for the oncology FDG-PET/CT data acquisition protocol: Synopsis of Version 1.0" targets 10.0-mm tumors to clear the PET/CT images, we found that no fewer than 90% of the 5.0mm diameter in the hot areas indicated SUV 4.0.
Next, to evaluate the study for the brain balance, we scanned for MCI and Alzheimer's disease using PET/CT images. It is often said that amyloid causes brain CBF to decrease. To test this, we fused CBF decrease images into accumulated amyloid images. Then, we drew red on the area of decreased CBF images and blue on the accumulated amyloid images. If the red and blue were in the same area, which turned green, then the result was that the green area was smaller than the red and blue areas. We concluded more pursuit of what has happened in the brain from now on.

Research Products

• [Presentation] Considering of the Ability of PET Imaging, including around BG (2017)
  • Author(s): 佐々木敏秋
  • Organizer: 第73回日本放射線技術学会総会学術大会
• [Presentation] Visual and Physical Evaluation of Small Hot Area under 6.0 mm and 3.5 mm Diameter Sources Using Background Counts (2017)
  • Author(s): Toshiaki Sasaki
  • Organizer: The 7th Asian Society of Nuclear Medicine Technology
• [Presentation] NEMA IEC BODY ファントムの線源作製短縮の一検討 (2016)
  • Author(s): 佐々木敏秋
  • Organizer: 第36回日本核医学技術学会総会学術大会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2016-11-03
• [Presentation] PET (2016)
  • Author(s): 佐々木敏秋
  • Organizer: 第72回日本放射線技術学会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2016-04-11
• [Presentation] ３DDRAMA法を利用した分解能補正効果の検討 (2015)
  • Author(s): 佐々木敏秋、寺崎一典、世良耕一郎
  • Organizer: 日本核医学会学術総会
  • Place of Presentation: 東京都 新宿
  • Year and Date: 2015-11-05
• [Presentation] 臨床用画像再構成と施設独自の画像再構成条件の評価研究 (2015)
  • Author(s): 佐々木敏秋
  • Organizer: 日本核医学技術学会東北地方会
  • Place of Presentation: 岩手県 盛岡市
  • Year and Date: 2015-08-29
• [Presentation] PET画像に係る視野内散乱線可視化の試み (2015)
  • Author(s): 佐々木敏秋
  • Organizer: 第71回日本放射線技術学会総会学術大会
  • Place of Presentation: 神奈川県 横浜市
  • Year and Date: 2015-04-17
• [Presentation] 高濃度RI投与時のSUV値の検討 (2014)
  • Author(s): 佐々木敏秋
  • Organizer: 日本核医学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-11-06 – 2014-11-08
• [Presentation] 散乱線を含んだSUV値の検討 (2014)
  • Author(s): 佐々木敏秋、寺崎一典、世良耕一郎
  • Organizer: 日本核医学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-11-06 – 2014-11-08
• [Presentation] がんFDG撮像法ガイドラインの基準線量とその2倍投与した場合のSUV値と施設間評価 (2014)
  • Author(s): 佐々木敏秋
  • Organizer: 日本放射線技術学会
  • Place of Presentation: 横浜
  • Year and Date: 2014-04-10 – 2014-04-14