Synthesis and radioprotective activity of new vitamin E derivatives
| Project/Area Number |
26460734
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical Physics and Radiological Technology
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
Keiko Inami 東京理科大学, 薬学部薬学科, 准教授 (00271247)
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| Co-Investigator(Kenkyū-buntansha) |
望月 正隆 東京理科大学, 薬学部薬学科, 教授 (10072414)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | ビタミンE / 6-クロマノール / ラジカル捕捉 / 放射線防御 / ベンゾクロマノール / 電子効果 / ハメット則 |
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| Outline of Final Research Achievements |
Radiotherapy is a method of cancer treatment based on destruction of malignant cells by ionizing radiation. Radiation therapy causes adverse effects that can be severe and cause permanent damages to the patient. Radioprotective agents are necessary for minimizing the severity and duration of toxicities associated with radiation therapy. The adverse toxicity was thought to be resulted from reactive oxygen species, which generated by the excitation of water molecules by radiation.
We focused on the radical scavenging function of vitamin E. Vitamin E derivatives were newly synthesized, and their radical scavenging activities were evaluated. Some of the vitamin E derivatives showed higher galvinoxyl and hydroxyl radical scavenging activities than vitamin E. In high-throughput screening for radioprotectors using rat thymocytes, some of the vitamin E derivatives showed the radio protecting activity. Therefore the vitamin E derivatives can be candidates as radioprotective agents.
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Report
(4 results)
Research Products
(34 results)
