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Clarification of the cell death mechanism by radical effect

Research Project

Project/Area Number 26460735
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical Physics and Radiological Technology
Research InstitutionHiroshima International University

Principal Investigator

haneda kiyofumi  広島国際大学, 保健医療学部, 准教授 (30280192)

Co-Investigator(Renkei-kenkyūsha) YOSHIOKA Munenori  広島国際大学, 保健医療学部, 助教 (80435057)
Research Collaborator KATAHIRA Kei  兵庫県立粒子線医療センター, 放射線技術部, 診療放射線技師
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsradical effect / gel dosimeter / Monte Carlo code / 放射線感受性 / 陽子線 / モンテカルロ / 粒子線治療 / ラジカル / ゲル線量計 / モンテカルロシミュレーション / 放射線治療 / ラジカル再結合 / ゲル検出器
Outline of Final Research Achievements

The purpose of this study was to estimate an impact on radical effect in the proton beams using a combined approach with physical data and gel data. This study used a polymer gel dosimeter. The spatial distribution of the physical dose was calculated by Monte Carlo code system PHITS.The simulation results were compared with measured the depth-dose distribution and good agreement was found, and the spatial distribution of a gel dose with threshold LET value of proton beam was calculated by the same code. Then, the relative distribution of the radical effect was calculated from the physical dose and gel dose. The relative distribution of the radical effect was calculated at each depth as the quotient of relative dose obtained using physical and gel dose. The agreement between the relative distributions of the gel dosimeter and Radical effect was good at the proton beams.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 2 results) Presentation (4 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Estimation of the influence of radical effect in the proton beams using a combined approach with physical data and gel data2016

    • Author(s)
      Kiyofumi Haneda
    • Journal Title

      Medical Imaging: Physics of Medical Imaging

      Volume: 9783 Pages: 97835R-97835R

    • DOI

      10.1117/12.2214690

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] An Attempt to Predict the Proton Relative Biological Effectiveness using Radical Recombination2015

    • Author(s)
      Kiyofumi Haneda
    • Journal Title

      IFMBE proceedings

      Volume: 51 Pages: 641-644

    • Related Report
      2015 Research-status Report
    • Acknowledgement Compliant
  • [Presentation] Estimation of the influence of radical effect in the proton beams2016

    • Author(s)
      Kiyofumi Haneda
    • Organizer
      EPSM2016
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2016-11-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Estimation of the influence of radical effect in the proton beams using a combined approach with physical data and gel data.2016

    • Author(s)
      Kiyofumi Haneda
    • Organizer
      SPIE medical imaging 2016
    • Place of Presentation
      Sandiego, USA
    • Year and Date
      2016-02-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] An Attempt to Predict the Proton Relative Biological Effectiveness using Radical Recombination2015

    • Author(s)
      Kiyofumi Haneda
    • Organizer
      World Congress on Medical Physics and Biomedical Engineering
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2015-06-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 強度変調放射線治療による患者に対する2次中性子線量の影響について2014

    • Author(s)
      羽根田清文
    • Organizer
      日本放射線影響学会
    • Place of Presentation
      鹿児島市
    • Year and Date
      2014-10-01 – 2014-10-03
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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