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A study of the dose evaluation using three-dimensional gel dosimeter for Boron-Neutron Capture Therapy

Research Project

Project/Area Number 26460736
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical Physics and Radiological Technology
Research InstitutionHiroshima International University

Principal Investigator

Hayashi Shin-ichiro  広島国際大学, 保健医療学部, 准教授 (20238108)

Co-Investigator(Kenkyū-buntansha) 前山 拓哉  北里大学, 理学部, 助教 (70612125)
Co-Investigator(Renkei-kenkyūsha) SAKURAI Yoshinori  京都大学, 原子炉実験所, 准教授 (20273534)
ISHIKAWA Kenichi  東京大学, 大学院・工学研究科, 教授 (70344025)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsゲル線量計 / 放射線治療 / ホウ素中性子捕捉療法 / MRI / リチウム6 / ホウ素10 / MAGAT / 医学物理学 / ポリマーゲル線量計 / BNCT / 線量評価 / 熱中性子 / 熱外中性子 / 色素ゲル線量計 / ガンマ線 / フリッケゲル線量計 / シミュレーション
Outline of Final Research Achievements

"Boron Neutron Capture Therapy (BNCT)" utilizing the nuclear reaction between boron incorporated into tumor cells by drugs and thermal neutrons irradiated from nuclear reactors and accelerators as a method of treating cancer by radiation has received attention in recent years. However, a method for evaluating the complicated dose distribution has not yet been well established.
In this research, we applied a dosimeter which is equivalent to water (tissue) equivalent, called a three-dimensional gel dosimeter which can evaluate the dose in three dimensions. In order to establish its use method, basic characteristics were evaluated and important basic data for clinical use was obtained.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (45 results)

All 2018 2017 2016 2015 2014 Other

All Journal Article (16 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Acknowledgement Compliant: 2 results,  Open Access: 2 results) Presentation (26 results) (of which Int'l Joint Research: 13 results,  Invited: 1 results) Remarks (3 results)

  • [Journal Article] Polymer gel dosimeter with AQUAJOINT as hydrogel matrix2018

    • Author(s)
      Maeyama Takuya、Ishida Yasuhiro、Kudo Yoshihiro、Fukasaku Kazuaki、Ishikawa Kenichi L.、Fukunishi Nobuhisa
    • Journal Title

      Radiation Physics and Chemistry

      Volume: 146 Pages: 121-125

    • DOI

      10.1016/j.radphyschem.2018.01.014

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Computational investigation of suitable polymer gel composition for the QA of the beam components of a BNCT irradiation field2017

    • Author(s)
      Tanaka Kenichi、Sakurai Yoshinori、Hayashi Shin-ichiro、Kajimoto Tsuyoshi、Uchida Ryohei、Tanaka Hiroki、Takata Takushi、Bengua Gerard、Endo Satoru
    • Journal Title

      Applied Radiation and Isotope

      Volume: 127 Pages: 253-259

    • DOI

      10.1016/j.apradiso.2017.06.014

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Fricke Gel Dosimeters2017

    • Author(s)
      前山 拓哉
    • Journal Title

      Japanese Journal of Medical Physics (Igakubutsuri)

      Volume: 37 Issue: 2 Pages: 99-106

    • DOI

      10.11323/jjmp.37.2_99

    • NAID

      130006943057

    • ISSN
      1345-5354, 2186-9634
    • Related Report
      2017 Annual Research Report
  • [Journal Article] Organic-Gelatin-Free Nanocomposite Fricke Gel Dosimeter.2017

    • Author(s)
      T. Maeyama, N. Fukunishi, K. L. Ishikawa, K. Fukasaku, S. Fukuda
    • Journal Title

      The Journal of Physical Chemistry B

      Volume: 121 Issue: 16 Pages: 4238-4246

    • DOI

      10.1021/acs.jpcb.6b11936

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Application of Gel Detector in Boron Neutron Capture Therapy2017

    • Author(s)
      櫻井 良憲,内田 良平
    • Journal Title

      Japanese Journal of Medical Physics (Igakubutsuri)

      Volume: 37 Issue: 3 Pages: 190-194

    • DOI

      10.11323/jjmp.37.3_190

    • NAID

      130006337872

    • ISSN
      1345-5354, 2186-9634
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 25 Development and Clinical Application of Three-dimensional Gel Dosimeter for Radiotherapy Treatment2017

    • Author(s)
      Hayashi Shin-ichiro
    • Journal Title

      RADIOISOTOPES

      Volume: 66 Issue: 11 Pages: 595-600

    • DOI

      10.3769/radioisotopes.66.595

    • NAID

      130006201417

    • ISSN
      0033-8303, 1884-4111
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymer Gel Dosimeter2017

    • Author(s)
      林 慎一郎
    • Journal Title

      Japanese Journal of Medical Physics (Igakubutsuri)

      Volume: 37 Issue: 2 Pages: 89-94

    • DOI

      10.11323/jjmp.37.2_89

    • NAID

      130006943056

    • ISSN
      1345-5354, 2186-9634
    • Related Report
      2017 Annual Research Report
  • [Journal Article] ポリマーゲル線量計による3 次元吸収線量分布評価に向けて2017

    • Author(s)
      林 慎一郎
    • Journal Title

      放射線(応用物理学会放射線分科会誌)

      Volume: 43 Pages: 9-11

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Evaluation of 3D Dose Distribution and Clinical Applications Using Polymer Gel Dosimeter2017

    • Author(s)
      小野 薫、藤本 幸恵、林 慎一郎、日置 一成、宮沢 正則、赤木 由紀夫、廣川 裕
    • Journal Title

      Japanese Journal of Medical Physics (Igakubutsuri)

      Volume: 37 Issue: 3 Pages: 165-172

    • DOI

      10.11323/jjmp.37.3_165

    • NAID

      130006337866

    • ISSN
      1345-5354, 2186-9634
    • Related Report
      2017 Annual Research Report
  • [Journal Article] Polymer Gel Dosimetry for the High-Dose-Rate Brachytherapy Using Ir-192 Source2017

    • Author(s)
      渡邉 祐介、水上 慎也、江口 昂、前山 拓哉、林 慎一郎、寺崎 剛史、山本 和正、首藤 宣昭、五味 勉
    • Journal Title

      Japanese Journal of Medical Physics (Igakubutsuri)

      Volume: 37 Issue: 3 Pages: 173-176

    • DOI

      10.11323/jjmp.37.3_173

    • NAID

      130006337867

    • ISSN
      1345-5354, 2186-9634
    • Related Report
      2017 Annual Research Report
  • [Journal Article] Dosimetric Evaluation of the Respiratory Interplay Effect During VMAT Delivery Using IPAGAT Polymer Gel Dosimeter2016

    • Author(s)
      Ono K, Fujimoto S, Hayashi S, Hioki K, Miyazawa M, Akagi Y, Hirokawa Y
    • Journal Title

      Medical Physics

      Volume: 43 Issue: 6Part24 Pages: 3634-3634

    • DOI

      10.1118/1.4956924

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison between Monte Carlo simulation and measurement with a 3D polymer gel dosimeter for dose distributions in biological samples2015

    • Author(s)
      T Furuta, T Maeyama, K L Ishikawa, N Fukunishi, K Fukasaku, S Takagi, S Noda, R Himeno and S Hayashi
    • Journal Title

      Physics in Medicine and Biology

      Volume: 60 Issue: 16 Pages: 6531-6546

    • DOI

      10.1088/0031-9155/60/16/6531

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dosimetric Evaluation of ArcCHECK and 3DVH System Using Customized Polymer Gel Dosimeter2015

    • Author(s)
      K Ono, S Fujimoto, S Hayashi, M Miyazawa, Y Akagi and Y Hirokawa
    • Journal Title

      Medical Physics

      Volume: 42 Issue: 6Part17 Pages: 3406-3406

    • DOI

      10.1118/1.4924679

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 三次元ゲル線量計2015

    • Author(s)
      林慎一郎
    • Journal Title

      放射線化学

      Volume: 100 Pages: 83-85

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preliminary study of MAGAT polymer gel dosimetry for Boron-Neutron Capture Therapy2015

    • Author(s)
      Shin-ichiro Hayashi, Yoshinori Sakurai, Ryohei Uchida, Minoru Suzuki, Shuji Usui and Takahiro Tominaga
    • Journal Title

      Journal of Physics: Conference Series

      Volume: 573 Pages: 012074-012074

    • DOI

      10.1088/1742-6596/573/1/012074

    • NAID

      120006654106

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Availability of a containerless polymer gel detector and a gelatin container2015

    • Author(s)
      Takahiro Tominaga, Munenori Yoshioka, Shin-ichiro Hayashi, Shuji Usui and Mitsutoshi Tada
    • Journal Title

      Journal of Physics: Conference Series

      Volume: 573 Pages: 012027-012027

    • DOI

      10.1088/1742-6596/573/1/012027

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] MRI-based Gel Dosimeter for Heavy ion Beam Cancer Therapy2018

    • Author(s)
      Takuya Maeyama
    • Organizer
      International Congress on Pure & Applied Chemistry (ICPAC) 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Reversible radiochromic gel dosimeter based on polyvinyl alcohol-iodide complex2017

    • Author(s)
      Shin-ichiro Hayashi, Takeyoshi Sunagawa, Kaoru Ono, Sachie Fujimoto, Yoshinori Sakura), Ryohei Uchida, Kenichi Tanaka, Genichiro Wakabayashi, Toshiharu Sakura
    • Organizer
      8th Japan-Korea Joint Meeting on Medical Physics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Investigation of 6Li compound suitable for beam component measurement using polymer gel detector for BNCT2017

    • Author(s)
      Kenichi Tanaka, Yuto Murakami, Rion Maruta, Shin-ichiro Hayashi, Tsuyoshi Kajimoto, Yuka Shigetake, Yoshinori Sakurai, Hiroki Tanaka, Satoru Endo
    • Organizer
      8th Japan-Korea Joint Meeting on Medical Physics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Survey on nuclide enhancing sensitivity of gel detector to epithermal neutrons for neutron capture therapy2017

    • Author(s)
      Yuto Murakami, Kenichi Tanaka, Tsuyoshi Kajimoto, Yoshinori Sakurai, Shin-ichiro Hayashi, Hiroki Tanaka, Satoru Endo
    • Organizer
      8th Japan-Korea Joint Meeting on Medical Physics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Estimation of Measurement-guided 4D Dose Verification System Using Customized Polymer Gel Dosimeter2017

    • Author(s)
      Kaoru Ono, Sachie Fujimoto, Shin-ichiro Hayashi, Kazunari Hioki, Masanori Miyazawa, Yukio Akagi, Yutaka Hirokawa
    • Organizer
      8th Japan-Korea Joint Meeting on Medical Physics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Parameter optimization for polymer gel dosimetry using 0.2T magnetic resonance imaging2017

    • Author(s)
      Nobuyoshi Tanki, Shin-ichiro Hayashi, Tatsuhiro Gotanda, Rumi Gotanda, Tadao Kuwano, Koutaro Iwasaki, Shinya Imai, Haruyuki Watanabe, Atsushi Noguchi, Toshizo Katsuda, Yoshihiro Takeda
    • Organizer
      8th Japan-Korea Joint Meeting on Medical Physics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of Measurement-Guided 4D Dose Reconstruction with Motion as a Perturbation Using IPAGAT Polymer Gel Dosimeter2017

    • Author(s)
      Kaoru Ono, Sachie Fujimoto, Shin-ichiro Hayashi, Kazunari Hioki, Masanori Miyazawa, Yukio Akagi, Yutaka Hirokawa
    • Organizer
      AAPM 59TH Annual Meeting & Exhibition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ポリビニルアルコール -ヨウ素錯体を用いた可逆的3 次元ラジオクロミックゲル線量計2017

    • Author(s)
      林慎一郎, 砂川武義, 小野薫, 藤本幸恵, 若林源一郎
    • Organizer
      第20回 ヨウ素学会シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] リチウムを添加したポリマーゲル線量計による中性子線量分布測定に向けた基礎的検討2017

    • Author(s)
      内田良平,林慎一郎,櫻井良憲,田中憲一,若林源一郎
    • Organizer
      第14回日本中性子捕捉療法学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Investigation of applicability of polymer gel dosimeters with Li compounds to dosimetry in boron neutron capture therapy2017

    • Author(s)
      Ryohei Uchida, Shin-ichiro Hayashi, Atsushi Sakon, Genichiro Wakabayashi, Kenichi Tanaka, Yoshinori Sakurai
    • Organizer
      The 9th Young Researchers' BNCT Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ポリマーゲル線量計を用いた前立腺癌高線量率小線源治療の線量分布測定2017

    • Author(s)
      江口昂,渡邉祐介,水上慎也,前山拓哉,林慎一郎,寺崎剛史,首藤宣昭,大類優奈,五味勉
    • Organizer
      第45回 日本放射線技術学会秋季学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] フラットベッドスキャナによる色素ゲル簡易線量解析システムの構築2017

    • Author(s)
      藤野圭介,小野 薫,藤本幸恵,林 慎一郎,赤木由紀夫,廣川 裕
    • Organizer
      第45回 日本放射線技術学会秋季学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Preliminary Study for the Beam Component Separation Using Polymer Gel Detector Containing Lithium Compounds2016

    • Author(s)
      Hayashi S, Tanaka K, Sakurai Y, Uchida R, Ono K, Fujimoto S, Fujiwara F, Suzuki S
    • Organizer
      17th International Congress on Neutron Capture Therapy
    • Place of Presentation
      Missouri, USA
    • Year and Date
      2016-10-02
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Study of Polymer Gel Dosimeter Response in Neutron Irradiation Fields2016

    • Author(s)
      Uchida R, Sakurai Y, Hayashi S, Tanaka K, Takata T, Narabayashi M, Suzuk M
    • Organizer
      17th International Congress on Neutron Capture Therapy
    • Place of Presentation
      Missouri, USA
    • Year and Date
      2016-10-02
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] nvestigation of beam component monitor for BNCT using gel detector2016

    • Author(s)
      Tanaka K, Sakurai Y, Kajimoto T, Hayashi S, Tanaka H, Takata T, Takada J, Endo S
    • Organizer
      17th International Congress on Neutron Capture Therapy
    • Place of Presentation
      Missouri, USA
    • Year and Date
      2016-10-02
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ラジオクロミックゲル線量計における添加剤濃度の影響2016

    • Author(s)
      林慎一郎,藤本幸恵,小野薫
    • Organizer
      第59回 放射線化学討論会
    • Place of Presentation
      高崎
    • Year and Date
      2016-09-20
    • Related Report
      2016 Research-status Report
  • [Presentation] 中性子照射場におけるポリマーゲル線量計の応答特性(2)2016

    • Author(s)
      内田良平,櫻井良憲,林慎一郎,田中憲一,髙田卓志,楢林正流,鈴木実
    • Organizer
      第13回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2016-08-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Investigation of beam component measurement using polymer gel detector for neutron capture therapy 22016

    • Author(s)
      Tanaka K, Sakurai Y, Hayashi S, Kajimoto T, TanakaH, Takata T, Takada J, Endo S
    • Organizer
      第111回 日本医学物理学会学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report
  • [Presentation] ポリマーゲル検出器を用いた中性子捕捉療法ビーム成分測定法の検討2015

    • Author(s)
      田中憲一、櫻井良憲、林慎一郎、梶本剛、田中浩基、高田卓志、 高田純、遠藤暁
    • Organizer
      第110回 日本医学物理学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 中性子捕捉療法ビーム成分分布測定のためのポリマーゲル検出器の設計検討2015

    • Author(s)
      田中憲一、櫻井良憲、林慎一郎、梶本剛、田中浩基、高田卓志、 高田純、遠藤暁
    • Organizer
      第12回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-09-04
    • Related Report
      2015 Research-status Report
  • [Presentation] 中性子照射場におけるポリマーゲル線量計の応答特性2015

    • Author(s)
      内田良平、林慎一郎、櫻井良憲
    • Organizer
      第12回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-09-04
    • Related Report
      2015 Research-status Report
  • [Presentation] Dosimetric Evaluation of ArcCHECK and 3DVH System Using Customized Polymer Gel Dosimeter2015

    • Author(s)
      K Ono, S Fujimoto, S Hayashi, M Miyazawa, Y Akagi, Y Hirokawa
    • Organizer
      AAPM 57TH Annual Meeting & Exhibition
    • Place of Presentation
      Anaheim, USA
    • Year and Date
      2015-07-12
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Preliminary study in the development of bone-equivalent polymer gel dosimeter2015

    • Author(s)
      Shin-ichiro Hayashi, Kaoru Ono, Sachie Fujimoto, Takahiro Kondo, Shuji Usui and Takahiro Tominaga
    • Organizer
      15th INTERNATIONAL CONGRESS OF RADIATION RESEARCH
    • Place of Presentation
      京都
    • Year and Date
      2015-05-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] BNCTのためのポリマーゲル線量計の基礎特性(2)2014

    • Author(s)
      林慎一郎,櫻井良憲,内田良平,鈴木実,笛吹修治,富永孝宏
    • Organizer
      2014年 秋季 第75回応用物理学会学術講演会
    • Place of Presentation
      札幌
    • Year and Date
      2014-09-17 – 2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Preliminary study of MAGAT polymer gel dosimetry for Boron-Neutron Capture Therapy2014

    • Author(s)
      Shin-ichiro Hayashi, Yoshinori Sakurai, Ryohei Uchida, Minoru Suzuki, Shuji Usui and Takahiro Tominaga
    • Organizer
      8th International Conference on 3D Radiation Dosimetry (IC3DDose 2014)
    • Place of Presentation
      Ystad, Sweden
    • Year and Date
      2014-09-04 – 2014-09-07
    • Related Report
      2014 Research-status Report
  • [Presentation] Availability of a containerless polymer gel detector and a gelatin container2014

    • Author(s)
      Takahiro Tominaga, Munenori Yoshioka, Shin-ichiro Hayashi, Shuji Usui and Mitsutoshi Tada
    • Organizer
      8th International Conference on 3D Radiation Dosimetry (IC3DDose 2014)
    • Place of Presentation
      Ystad, Sweden
    • Year and Date
      2014-09-04 – 2014-09-07
    • Related Report
      2014 Research-status Report
  • [Remarks] 広島国際大学DOSGELグループ

    • URL

      http://www.hirokoku.jp/hr/dosgel/index-j.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 広島国際大学 DOSGEL group

    • URL

      http://www.hirokoku.jp/hr/dosgel/index-j.html

    • Related Report
      2016 Research-status Report 2014 Research-status Report
  • [Remarks] 広島国際大学DOSGEL Group

    • URL

      http://www.hirokoku.jp/hr/dosgel/index-j.html

    • Related Report
      2015 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

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