Prevention of metabolic syndrome and atherosclerosis by personal genome information

• Project/Area Number: 26460741
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: MURAMATSU Masaaki 東京医科歯科大学, 難治疾患研究所, 教授 (50230008)
• Co-Investigator(Renkei-kenkyūsha): SATO Noriko 東京医科歯科大学, 難治疾患研究所, 准教授 (70280956) ; DAIMON Makoto 弘前大学, 医学部内分泌代謝内科, 教授 (20241698) ; SAWABE Motoji 東京医科歯科大学, 大学院保健衛生学研究科, 教授 (30196331) ; YAMASHITA Naohide 東京大学, 医科学研究所・先端診療部, 教授 (90174680)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 遺伝子多型 / リスク予測 / 多因子疾患 / 生活習慣病 / 予防行動 / ゲノム疫学 / 遺伝子検査 / 行動変容 / 遺伝子・環境の相互作用 / パーソナルゲノム / 予防医学 / 遺伝学的検査 / ゲノムリテラシー / 糖尿病 / 動脈硬化

Outline of Final Research Achievements

We studied how genetic tests for common chronic diseases, such as metabolic syndrome and atherosclerosis may be useful and be applied for patients health care. We employed 30 GWAS identified DM susceptible variants to construct a risk prediction test by using information from literature and databases. We found that gene test itself may not be not valid for disease prediction, while additional information of BMI and BP will merit the test (C-statistics, AUV=0.707). This prompt us to test whether it is feasible to provide genetic tests for common chronic diseases, under the guidance of medical doctor, and to study whether such session leads to health promotion attitude for the patients.

Research Products

• [Journal Article] Effectiveness of personal genomic testing for disease-prevention behavior when combined with careful consultation with a physician: a preliminary study. (2018)
  • Author(s): Hayashi M, Watanabe A, Muramatsu M, Yamashita N
  • Journal Title: BMC Res Notes. Volume: 11 Issue: 1 Pages: 2018-2018
  • DOI: 10.1186/s13104-018-3330-9
  • Peer Reviewed / Open Access
• [Journal Article] Long noncoding RNA variations in cardiometabolic diseases. (2017)
  • Author(s): Dechamethakun S, Muramatsu M
  • Journal Title: J Hum Genet Volume: 62 Issue: 1 Pages: 97-104
  • DOI: 10.1038/jhg.2016.70
  • Peer Reviewed
• [Journal Article] Association of polymorphisms of the transporter associated with antigen processing (TAP2) gene with pulmonary tuberculosis in an elderly Japanese population. (2016)
  • Author(s): Thu KS, Sato N, Ikeda S, Naka-Mieno M, Arai T, Mori S, Sawabe M, Muramatsu M, Tanaka M.
  • Journal Title: APMIS. Volume: 124 Issue: 8 Pages: 675-680
  • DOI: 10.1111/apm.12562
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association of ZFHX3 gene variation with atrial fibrillation, cerebral infarction, and lung thromboembolism: An autopsy study. (2016)
  • Author(s): Zaw KT, Sato N, Ikeda S, Thu KS, Mieno MN, Arai T, Mori S, Furukawa T, Sasano T, Sawabe M, Tanaka M, Muramatsu M.
  • Journal Title: J Cardiol Volume: S0914-5087 Issue: 2 Pages: 30290-30298
  • DOI: 10.1016/j.jjcc.2016.11.005
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Likelihood ratio-based integrated personal risk assessment of type 2 diabetes (2014)
  • Author(s): Sato N, Htun NC, Daimon M, Tamiya G, Kato K, Kubota I, Ueno Y, Yamashita H, Fukao A, Kayama T, Muramatsu M
  • Journal Title: Endocrine Journal Volume: 61 Pages: 967-988
  • NAID: 130004704360
  • Peer Reviewed / Open Access
• [Presentation] Association of polymorphisms of the transporter associated with antigen processing (TAP2) gene with pulmonary tuberculosis in an elderly Japanese population. (2016)
  • Author(s): Thu KS, Sato N, Ikeda S, Naka-Mieno M, Arai T, Mori S, Sawabe M, Muramatsu M, Tanaka M. Association of polymorphisms of the transporter associated with antigen processing (TAP2) gene with pulmonary tuberculosis in an elderly Japanese population.
  • Organizer: 日本分子生物学会
  • Place of Presentation: パシフィコ横浜 神奈川県 横浜市
• [Presentation] Association of ZFHX3 gene variation with atrial fibrillation, cerebral infarction, and lung thromboembolism (2016)
  • Author(s): Zaw KT, Sato N, Ikeda S, Thu KS, Mieno MN, Arai T, Mori S, Furukawa T, Sasano T, Sawabe M, Tanaka M, Muramatsu M
  • Organizer: 日本分子生物学会
  • Place of Presentation: パシフィコ横浜 神奈川県 横浜市
• [Presentation] 多因子疾患の遺伝子検査がもたらす健康観・疾病観の変化 (2015)
  • Author(s): 村松正明
  • Organizer: 第56回日本人間ドック学会学術大会
  • Place of Presentation: 神奈川県 パシフィコ横浜
  • Year and Date: 2015-07-31
  • Invited
• [Presentation] 高齢者連続剖検例における腹部大動脈瘤のエクソーム一塩基変異の網羅的解析 (2015)
  • Author(s): 前田裕子
  • Organizer: 日本老年学会
  • Place of Presentation: 神奈川県 パシフィコ横浜
  • Year and Date: 2015-06-12
• [Presentation] 尤度比を用いた２型糖尿病の統合的リスク評価 (2014)
  • Author(s): 佐藤憲子
  • Organizer: 日本人類遺伝学会第５９回大会
  • Place of Presentation: 東京
  • Year and Date: 2014-11-20
• [Presentation] The effect of genetic test for common diseases on the perception of health and illness (2014)
  • Author(s): 村松正明
  • Organizer: 生命医薬情報学連合大会
  • Place of Presentation: 仙台
  • Year and Date: 2014-10-02