Study of mortality risk of Hiroshima atomic bomb victims during 5 years just after the bombing

• Project/Area Number: 26460747
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Hiroshima University
• Principal Investigator: Otani Keiko 広島大学, 原爆放射線医科学研究所, 研究員 (20243587)
• Co-Investigator(Kenkyū-buntansha): 大瀧 慈 広島大学, 原爆放射線医科学研究所, 名誉教授 (20110463) ; 佐藤 健一 広島大学, 原爆放射線医科学研究所, 准教授 (30284219) ; 冨田 哲治 県立広島大学, 経営情報学部, 准教授 (60346533)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 残留放射線 / 広島原爆 / 入市者 / 広島原爆被爆者 / 初期被爆 / 間接被曝 / 生存解析 / 直接被ばく者 / 間接被ばく者

Outline of Final Research Achievements

A-bomb radiation exposure is generally divided into two types: direct exposure to gamma-ray as well as prompt and delayed neutrons from the initial radiation explosion, and indirect exposure from residual radiation comprising neutron activated radiation in soil and other materials as well as fallout from the nuclear explosion. The results of this study showed that increase of mortality risk was detected immediately after the bombing in distal survivors or entrants who were exposed by negligible low radiation dose. We must reconsider that such low estimates of residual-radiation dose have health effects in case that breathing dust contaminated with radioactive materials.

Research Products

• [Journal Article] 広島原爆における粉じん被ばくの健康影響について─陸軍船舶特別幹部候補生アンケート調査を用いて─ (2016)
  • Author(s): 大谷敬子. 大瀧 慈
  • Journal Title: 長崎医学会雑誌 Volume: 91 Pages: 210-215
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 広島原爆被曝者における後障害の主要因は放射線微粒子被曝である, (2016)
  • Author(s): 大瀧 慈, 大谷敬子, 冨田哲治, 佐藤裕哉, 原 憲行, 川上秀史, 瀧原義宏, 星 正治, 佐藤健一
  • Journal Title: 長崎医学会雑誌 Volume: 91 Pages: 216-223
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 広島大学におけるDS02準拠の原爆線量評価体系(ABS16D)の実装について (2016)
  • Author(s): 佐藤健一, 冨田哲治, 大谷敬子, 佐藤裕哉, 原憲行, 川上秀史, 瀧原義宏, 星正治, 大瀧慈
  • Journal Title: 長崎医学会雑誌 Volume: 91 Pages: 197-201
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 広島原爆被爆者位置情報の拡張の試み (2016)
  • Author(s): 佐藤裕哉, 佐藤健一, 冨田哲治, 原憲行, 布施博之, 大谷敬子, 川上秀史, 瀧原義宏, 星正治, 大瀧慈
  • Journal Title: 長崎医学会雑誌 Volume: 91 Pages: 206-209
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 広島原爆被爆者における健康障害の主要因は放射性微粒子である, (2016)
  • Author(s): 大瀧 慈, 大谷敬子
  • Journal Title: 科学 Volume: 86 Pages: 819-830
  • Acknowledgement Compliant
• [Journal Article] 広島原爆被爆者における固形がん死亡超過の主要因は初期被爆線量ではない－性別・被爆時年齢階級別の初期線量・被爆距離の説明力の比較解析－ (2016)
  • Author(s): 大瀧 慈，大谷敬子，冨田哲治, 佐藤裕哉, 原憲行, 川上秀史, 瀧原義宏, 星正治, 佐藤健一
  • Journal Title: 広島医学 Volume: 69 Pages: 369-373
  • Acknowledgement Compliant
• [Journal Article] 広島原爆被爆者における性別・被爆時年齢階級別固形がん死亡危険度の被爆時所在地に関する空間分布の特徴 (2016)
  • Author(s): 冨田哲治, 佐藤健一, 大谷敬子, 佐藤裕哉, 原憲行, 川上秀史, 瀧原義宏, 星正治, 大瀧慈
  • Journal Title: 広島医学 Volume: 69 Pages: 345-2016
  • Acknowledgement Compliant
• [Journal Article] Workshop report on Atomic bomb dosimetry-Review of dose related factors for the evaluation of exposures to residual radiation at Hiroshima and Nagasaki (2015)
  • Author(s): Kerr G, Egbert S, Al-Nabulsi I, Bailiff I, Beck H, Belukha I, Cockayne J, Cullings H, Eckerman F, Granovskaya E, Grant E, Hoshi M, Kaul D, Kryuchkov V, Mannis D, Ohtaki M, Otani M, Shinkarev S, Simon S, Spriggs G, Stepanenko V, Stricklin D, Weiss J, Weitz R, Woda C, Worthington P, Yamoto K, Young R
  • Journal Title: Health Physics Volume: 109(6) Issue: 6 Pages: 582-600
  • DOI: 10.1097/hp.0000000000000395
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 広島原爆被爆者における原爆投下直後から5年間での死亡危険度の解明 (2014)
  • Author(s): 大谷敬子, 大瀧 慈, 冨田哲治, 原 憲行, 佐藤裕哉, 星 正治, 佐藤健一
  • Journal Title: 長崎医学会雑誌 Volume: 89 Pages: 227-233
  • Peer Reviewed
• [Journal Article] 発がん死亡危険度に対する初期放射線被曝による線量反応関係は過大評価されているー初期放射線の影響強度に被爆時年齢依存性は検出されずー (2014)
  • Author(s): 大瀧 慈，冨田哲治，大谷敬子，佐藤裕哉，原 憲行，井森晋平，川上秀史，田代 聡，星 正治，合原一幸，佐藤健一
  • Journal Title: 長崎医学会雑誌 Volume: 89 Pages: 244-248
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 広島原爆被爆者における死亡危険度地図の推定範囲拡大の試み (2014)
  • Author(s): 冨田哲治, 佐藤健一, 大谷敬子, 佐藤裕哉, 原 憲行, 川上秀史, 田代 聡, 星 正治, 大瀧 慈
  • Journal Title: 長崎医学会雑誌 Volume: 89 Pages: 222-226
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 広島原爆被爆者コホートデータにおける壮年期近距離被爆者の死亡危険度について (2014)
  • Author(s): 佐藤健一, 冨田哲治, 大谷敬子, 佐藤裕哉, 原 憲行, 川上秀史, 田代 聡, 星 正治, 大瀧 慈
  • Journal Title: 長崎医学会雑誌 Volume: 89 Pages: 234-239
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Re-analysis of solid cancer mortality among Hiroshima A-bomb survivors being exposed at region with the distance between 1.2km and 2.0km from the hypocenter (2016)
  • Author(s): Otani K, Tonda T, Satoh K, Hara N, Kawakami H, Takihara Y, Hoshi M, Ohtaki M
  • Organizer: The 20th Hiroshima International Symposium
  • Place of Presentation: Hiroshima
  • Year and Date: 2016-01-10
  • Int'l Joint Research
• [Presentation] 広島原爆における粉塵被曝の健康影響について― 陸軍船舶特別幹部候補生アンケート調査を用いて― (2016)
  • Author(s): 大谷敬子、大瀧 慈
  • Organizer: 第57回原子爆弾後障害研究会
  • Place of Presentation: 長崎
• [Presentation] 広島原爆の直爆者における固形がん死亡危険度の被爆時所在地依存性に基づく曝露要因の検討 (2016)
  • Author(s): 大瀧 慈, 大谷敬子, 冨田哲治, 原 憲行, 佐藤裕哉, 川上秀史, 瀧原義宏, 星 正治, 佐藤健一
  • Organizer: 第57回原爆後障害研究会
  • Place of Presentation: 長崎
• [Presentation] 広島大学におけるDS02準拠の原爆線量評価体系(ABS16D)の実装について (2016)
  • Author(s): 佐藤健一，冨田哲治，大谷敬子，佐藤裕哉，原 憲行，川上秀史，瀧原義宏，星 正治，大瀧 慈
  • Organizer: 第57回原爆後障害研究会
  • Place of Presentation: 長崎
• [Presentation] モンテカルロ法による内部被曝の場合の線量率の時空間分布の数理特性解析 (2016)
  • Author(s): 大瀧 慈, 保田浩志
  • Organizer: 放射線影響学会
  • Place of Presentation: 広島
• [Presentation] Effects of 60Co gamma-ray irradiation and of 56Mn powders exposure on locomotor activity of rats, International Symposium “Mn-56 experiments and the results - Possibility of the small particle effects - (2016)
  • Author(s): Otani Keiko, Ohtaki Megu, Hoshi Masaharu:
  • Organizer: International Symposium on Possibility of health effect of radioactive micro-particles
  • Place of Presentation: Hiroshima
• [Presentation] Study of solid cancer mortalities among Hiroshima early entrants, 1970-2010 (2016)
  • Author(s): Otani K, Tonda T, Satoh K, Hoshi M, Takihara Y, Ohtaki M
  • Organizer: International Symposium on Possibility of health effect of radioactive micro-particles
  • Place of Presentation: Hiroshima
• [Presentation] Dose-rate distribution formed by small radioactive particles in a human body: a Monte Carlo simulation study (2016)
  • Author(s): Ohtaki Megu, Hiroshi Yasuda
  • Organizer: International Symposium on Possibility of health effect of radioactive micro-particles
  • Place of Presentation: Hiroshima
• [Presentation] Evaluation of non-initial radiation exposure effect on solid cancer mortality among Hiroshima atomic bomb survivors: Poisson regression analysis using distance from the hypocenter and age at exposure as explanatory variables (2015)
  • Author(s): Kenichi Satoh, Tetsuji Tonda, Keiko Otani, Yuya Sato, Noriyuki Hara, Hideshi Kawakami, Yoshihiro Takihara, Masaharu Hoshi, Megu Ohtaki
  • Organizer: The 5th International Symposium of RIRBM, Hiroshima University -Biological Effects of Low Dose Radiation-
  • Place of Presentation: Hiroshima
  • Year and Date: 2015-03-02 – 2015-03-03
• [Presentation] 間接被爆による固形がん死亡リスクの上昇の実態おびその背景 - 広島原爆入市者データを用いて - (2015)
  • Author(s): 大谷 敬子，大瀧 慈，冨田 哲治，原 憲行，星 正治，佐藤 健一
  • Organizer: 科研費シンポジウム, バイオ統計学の挑戦と貢献
  • Place of Presentation: 福岡
  • Year and Date: 2015-02-02 – 2015-02-03
  • Invited
• [Presentation] Source and effects of residual radiation: excess mortality risk from solid cancers based on Hiroshima A-bomb early entrants cohort data, 1970-2010 (2015)
  • Author(s): K. Otani, T. Tonda, K. Satoh, N. Hara, H. Kawakami, T. Takihara, M. Hoshi, M. Ohtaki
  • Organizer: nternational Workshop for the Residual Radiation from the Hiroshima and Nagasaki A-bombs
  • Place of Presentation: Hiroshima
  • Year and Date: 2015-01-26
• [Presentation] Evaluating non-initial radiation exposure on solid cancer mortality among Hiroshima A-bomb survivors using Poisson regression analysis (2015)
  • Author(s): K. Satoh, T. Tonda, K. Otani, Y. Sato, N. Hara, H. Kawakami, Y. Takihara, M. Hoshi, M. Ohtaki
  • Organizer: International Workshop for the Residual Radiation from the Hiroshima and Nagasaki A-bombs
  • Place of Presentation: Hiroshima
  • Year and Date: 2015-01-26
• [Presentation] Estimation of effect of non-initial radiation exposure on solid cancer mortality among Hiroshima atomic bomb survivors with Cox regression (2015)
  • Author(s): N. Hara, K. Otani, T. Tonda, Y. Sato, H. Kawakami, M. Hoshi, K. Satoh, M. Ohtaki
  • Organizer: International Workshop for the Residual Radiation from the Hiroshima and Nagasaki A-bombs, Hiroshima
  • Place of Presentation: Hiroshima
  • Year and Date: 2015-01-26
• [Presentation] Mortality risk of Hiroshima-atomic bomb victims within five years after the bombing (2015)
  • Author(s): K. Otani, M. Ohtaki, T. Tonda, N. Hara, M. Hoshi, K. Satoh
  • Organizer: 第25回日本疫学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-01-21 – 2015-01-23
• [Presentation] 非初期放射線による固形癌超過死亡危険度の定量化について,－広島原爆被爆者コホートデータを用いて－ (2014)
  • Author(s): 大谷敬子，大瀧 慈 ，冨田哲治，佐藤裕哉，原 憲行, 伊森晋平, 川上秀史, 星 正治，佐藤健一
  • Organizer: 日本放射線影響学会第57回大会
  • Place of Presentation: 鹿児島
  • Year and Date: 2014-10-01
• [Presentation] 広島原爆被爆者での固形癌超過死亡危険度における非初期線量依存性について (2014)
  • Author(s): 大瀧 慈, 大谷敬子, 冨田哲治, 佐藤裕哉, 原 憲行, 伊森晋平, 川上秀史, 合原一幸, 星 正治, 佐藤健一
  • Organizer: 2014年度統計学会関連連合大会
  • Place of Presentation: 東京
  • Year and Date: 2014-09-13 – 2014-09-16
• [Presentation] Excess Risk of Solid Cancer Mortality among Early Entrants in Hiroshima City after A-bombing - Using half-life of radionuclides - (2014)
  • Author(s): Keiko Otani, Megu Ohtaki, Tetsuji Tonda, Yuya Sato, Noriyuki Hara, Hideshi Kawakami, Satoshi Tashiro, Masaharu Hoshi, Kenichi Satoh
  • Organizer: Workshop of Health Physics Conference 2014
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2014-07-15
  • Invited
• [Presentation] Excess risk of mortality of solid cancers due to initial radiation exposure in Hiroshima atomic bomb survivors has been over-estimated (2014)
  • Author(s): Ohtaki M, Otani K, Tonda T, Sato Y, Hara N, Imori S, Kawakami H, Tashiro S, Aihara K, Hoshi M, Satoh K
  • Organizer: Workshop of Health Physics Conference 2014
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2014-07-15
  • Invited
• [Presentation] Effect of Age at Exposure on Excess Risk of Solid Cancer Mortality In Hiroshima Atomic Bomb Survivors (2014)
  • Author(s): Ohtaki M, Otani K, Tonda T, Sato Y, Hara N, Imori S, Kawakami H, Tashiro S, Aihara K, Hoshi M, Satoh K
  • Organizer: Tech. Session of Health Physics Conference 2014
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2014-07-15
  • Invited
• [Presentation] Studies of Cancer Mortality Risk among Early Entrants after Hiroshima Bombing: 1970-2010 (2014)
  • Author(s): Keiko Otani, Megu Ohtaki, Tetsuji Tonda, Yuya Sato, Noriyuki Hara, Hideshi Kawakami, Satoshi Tashiro, Masaharu Hoshi, Kenichi Satoh
  • Organizer: International Biometrics Conference 2014
  • Place of Presentation: Florence, Italy
  • Year and Date: 2014-07-10
• [Presentation] Multistage carcinogenesis model and its application to analysis of solid cancer mortality among atomic bomb survivors in Hiroshima (2014)
  • Author(s): Ohtaki M, Otani K, Tonda T, Sato Y, Hara N, Imori S, Kawakami H, Tashiro S, Aihara K, Hoshi M, Satoh K
  • Organizer: International Biometrics Conference 2014
  • Place of Presentation: Florence, Italy
  • Year and Date: 2014-07-06 – 2014-07-11
• [Presentation] 広島島原爆被爆者における原爆投下直後から5年間での死亡危険度の解明 (2014)
  • Author(s): 大谷敬子, 大瀧 慈, 冨田哲治，原 憲行, 佐藤裕哉, 星 正治，佐藤健一
  • Organizer: 第55回原爆後障害研究会
  • Place of Presentation: 長崎
  • Year and Date: 2014-06-01
• [Presentation] 広島原爆被爆者における死亡危険度地図の推定範囲拡大の試み (2014)
  • Author(s): 冨田哲治, 佐藤健一, 大谷敬子, 佐藤裕哉, 原 憲行, 川上秀史, 田代 聡, 星 正治, 大瀧 慈
  • Organizer: 第55回原子爆弾後障害研究会
  • Place of Presentation: 長崎
  • Year and Date: 2014-06-01
• [Presentation] 広島大学原爆被爆者コホートデータにおける壮年期近距離被爆者の死亡危険度について (2014)
  • Author(s): 佐藤健一，冨田哲治，大谷敬子，佐藤裕哉，原 憲行，川上秀史，田代聡，星 正治，大瀧 慈
  • Organizer: 第55回原子爆弾後障害研究会
  • Place of Presentation: 長崎
  • Year and Date: 2014-06-01
• [Presentation] 発がん死亡危険度に対する初期放射線被曝による線量反応関係は過大評価されている－初期放射線の影響強度に被爆時年齢依存性は検出されず－ (2014)
  • Author(s): 大瀧 慈, 冨田哲治, 大谷敬子, 佐藤裕哉, 原 憲行, 伊森晋平, 川上秀史, 田代 聡 ,合原一幸, 星 正治, 佐藤健一
  • Organizer: 第55回原子爆弾後障害研究会
  • Place of Presentation: 長崎
  • Year and Date: 2014-06-01
• [Funded Workshop] The 20th Hiroshima International Symposium (2016)
  • Place of Presentation: Hiroshima
  • Year and Date: 2016-01-10