Risk factors for atrial fibrillation in a general Japanese population: the Hisayama Study

• Project/Area Number: 26460748
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Kyushu University
• Principal Investigator: Jun Hata 九州大学, 医学研究院, 准教授 (00448432)
• Co-Investigator(Kenkyū-buntansha): 清原 裕 九州大学, 医学研究院, 教授 (80161602)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 心房細動 / 危険因子 / 高血圧 / コレステロール / 高感度CPR / コホート研究 / LDLコレステロール

Outline of Final Research Achievements

(1) Risk prediction model for the development of atrial fibrillation: A total of 2628 residents of Hisayama Town aged 40 years or over in 1988 were followed up for 14 years. In multivariable-adjusted model, older age, male sex, lower cholesterol, obesity, heart murmur, and electrocardiogram abnormalities were significantly and independently associated with the development of atrial fibrillation. We developed a risk prediction model for atrial fibrillation using these risk factors.
(2) Association of high-sensitivity CRP levels with the development of atrial fibrillation: Using 19-year follow-up data of this cohort, we investigated the association of serum levels of high-sensitivity CRP, a marker for chronic inflammation, with the risk of atrial fibrillation. Elevated CRP was a significant and independent risk factor for atrial fibrillation.

Research Products

• [Journal Article] Serum Uric Acid as a Risk Factor for Chronic Kidney Disease in a Japanese Community – The Hisayama Study – (2016)
  • Author(s): 1.Takae K, Nagata M, Hata J, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Tsuruya K, Kitazono T, Kiyohara Y, Ninomiya T.
  • Journal Title: Circulation Journal Volume: 80 Issue: 8 Pages: 1857-1862
  • DOI: 10.1253/circj.CJ-16-0030
  • NAID: 130005166109
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Serum angiopoietin-like protein 2 (ANGPTL2) is a novel risk factor for cardiovascular disease in the community: the Hisayama Study. (2016)
  • Author(s): Hata J, Mukai N, Nagata M, Ohara T, Yoshida D, Kishimoto H, Shibata M, Hirakawa Y, Endo M, Ago T, Kitazono T, Oike Y, Kiyohara Y & Ninomiya T.
  • Journal Title: Arteriosclerosis, Thrombosis, and Vascular Biology Volume: 36 Issue: 8 Pages: 1686-1691
  • DOI: 10.1161/atvbaha.116.307291
  • Peer Reviewed / Open Access
• [Journal Article] Association between diabetes and hippocampal atrophy in elderly Japanese: the Hisayama Study. (2016)
  • Author(s): 4.Hirabayashi N, Hata J, Ohara T, Mukai N, Nagata M, Shibata M, Gotoh S, Furuta Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N, Kiyohara Y, Ninomiya T
  • Journal Title: Diabetes Care Volume: 39 Issue: 9 Pages: 1543-1549
  • DOI: 10.2337/dc15-2800
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The long-term association between physical activity and risk of dementia in the community: the Hisayama Study. (2016)
  • Author(s): Hiro Kishimoto, Tomoyuki Ohara, Jun Hata, Toshiharu Ninomiya, Daigo Yoshida, Naoko Mukai, Masaharu Nagata, Fumie Ikeda, Masayo Fukuhara, Shuzo Kumagai, Shigenobu Kanba, Takanari Kitazono, Yutaka Kiyohara.
  • Journal Title: Euro J Epidemiol Volume: 31 Issue: 3 Pages: 267-274
  • DOI: 10.1007/s10654-016-0125-y
  • Peer Reviewed / Open Access
• [Journal Article] Midlife and late-life smoking and risk of dementia in the community: the Hisayama Study (2015)
  • Author(s): Ohara T, Ninomiya T, Hata J, Ozawa M, Yoshida D, Mukai N, Nagata M, Iwaki T, Kitazono T, Kanba S, Kiyohara Y
  • Journal Title: J Am Geriatr Soc Volume: 63 Issue: 11 Pages: 2332-2339
  • DOI: 10.1111/jgs.13794
  • Peer Reviewed / Open Access
• [Journal Article] Hematocrit and the risk of cardiovascular disease in a Japanese community: the Hisayama Study (2015)
  • Author(s): Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Ago T, Kitazono T, Kiyohara Y
  • Journal Title: Atherosclerosis Volume: 242 Issue: 1 Pages: 199-204
  • DOI: 10.1016/j.atherosclerosis.2015.07.014
  • Peer Reviewed
• [Journal Article] Association of hemoglobin A1c and glycated albumin with carotid atherosclerosis in community-dwelling Japanese subjects: the Hisayama Study (2015)
  • Author(s): Mukai N, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y
  • Journal Title: Cardiovasc Diabetol Volume: 14 Issue: 1 Pages: 84-84
  • DOI: 10.1186/s12933-015-0247-7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Trends in the Incidence and Survival of Intracerebral Hemorrhage by its Location in a Japanese Community (2014)
  • Author(s): Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Shikata K, Kamouchi M, Kitazono T, Kiyohara Y
  • Journal Title: Circulation Journal Volume: 78 Issue: 2 Pages: 403-409
  • DOI: 10.1253/circj.CJ-13-0811
  • NAID: 130003382214
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Non-high-density lipoprotein cholesterol and the development of coronary heart disease and stroke subtypes in a general Japanese population: the Hisayama Study. (2014)
  • Author(s): Imamura T, Doi Y, Ninomiya T, Hata J, Nagata M, Ikeda F, Mukai N, Hirakawa Y, Yoshida D, Fukuhara M, Kitazono T, Kiyohara Y
  • Journal Title: Atherosclerosis Volume: 233 Issue: 2 Pages: 343-348
  • DOI: 10.1016/j.atherosclerosis.2014.01.005
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Milk and dairy consumption and risk of dementia in an elderly Japanese population: the Hisayama Study. (2014)
  • Author(s): Ozawa M, Ohara T, Ninomiya T, Hata J, Yoshida D, Mukai N, Nagata M, Uchida K, Shirota T, Kitazono T, Kiyohara Y
  • Journal Title: J Am Geriatr Soc Volume: 62 Issue: 7 Pages: 1224-1230
  • DOI: 10.1111/jgs.12887
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A Low Ankle Brachial Index is Associated with an Increased Risk of Cardiovascular Disease: The Hisayama Study (2014)
  • Author(s): Kojima I, Ninomiya T, Hata J, Fukuhara M, Hirakawa Y, Mukai N, Yoshida D, Kitazono T, Kiyohara Y
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 21 Issue: 9 Pages: 966-973
  • DOI: 10.5551/jat.22608
  • NAID: 130004690937
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Midlife and late-life handgrip strength and risk of cause-specific death in a general Japanese population: the Hisayama Study. (2014)
  • Author(s): Kishimoto H, Hata J, Ninomiya T, Nemeth H, Hirakawa Y, Yoshida D, Kumagai S, Kitazono T, Kiyohara Y
  • Journal Title: J Epidemiol Community Health Volume: 68 Issue: 7 Pages: 663-668
  • DOI: 10.1136/jech-2013-203611
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 性別・年齢階級別にみた脳卒中とその危険因子の疫学 (2017)
  • Author(s): 秦 淳
  • Organizer: 第42回日本脳卒中学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2017-03-16
  • Invited
• [Presentation] 心血管病の新しい危険因子としてのバイオマーカー：久山町研究 (2016)
  • Author(s): 秦 淳，二宮利治
  • Organizer: 第64回日本心臓病学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-09-24
  • Invited
• [Presentation] 高血圧と心臓合併症の疫学：久山町研究を中心に (2015)
  • Author(s): 秦 淳，清原 裕，二宮 利治
  • Organizer: 第38回日本高血圧学会総会
  • Place of Presentation: 松山市
  • Year and Date: 2015-10-11
  • Invited
• [Presentation] 糖代謝異常・脂質異常症と脳卒中の疫学：久山町研究（シンポジウム） (2015)
  • Author(s): 秦 淳、清原 裕
  • Organizer: 第40回日本脳卒中学会総会
  • Place of Presentation: 広島市
  • Year and Date: 2015-03-26
  • Invited
• [Presentation] 日本人における心血管病危険因子の時代的変化と特徴：久山町研究（シンポジウム） (2014)
  • Author(s): 秦 淳、清原 裕
  • Organizer: 第17回日本栓子検出と治療学会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-10-05
  • Invited
• [Presentation] 心血管病と認知症の疫学：久山町研究（シンポジウム） (2014)
  • Author(s): 秦 淳、清原 裕
  • Organizer: 第56回日本老年医学会学術集会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-06-12
  • Invited
• [Remarks] 久山町研究
  • URL: http://www.hisayama.med.kyushu-u.ac.jp/