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Incidence of dementia and Parkinsonism-dementia complex (PDC) in Wakayama prefecture with previous high incidence of ALS/PDC

Research Project

Project/Area Number 26460753
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionWakayama Medical University

Principal Investigator

Hironishi Masaya  和歌山県立医科大学, 医学部, 講師 (80316116)

Co-Investigator(Kenkyū-buntansha) 伊東 秀文  和歌山県立医科大学, 医学部, 教授 (20250061)
高 真守  和歌山県立医科大学, 医学部, 助教 (20554629)
紀平 為子  関西医療大学, 保健医療学部, 教授 (30225015)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords紀伊半島 / 和歌山県 / 筋萎縮性側索硬化症 / パーキンソン認知症複合 / 認知症 / 紀伊ALS/PDC / 紀伊ALS / 牟婁病 / 発症率 / 有病率
Outline of Final Research Achievements

A high incidence of amyotrophic lateral sclerosis (ALS) has been observed in the southern part of Wakayama Prefecture. Furthermore, the incidence of ALS is known to be high among Chamorro people in Guam Island. Although the incidence of ALS has decreased, Parkinson & dementia complex (PDC) and Guam dementia remain prevalent in Guam. This study aims to investigate the current incidence of ALS and the presence of PDC in Wakayama Prefecture as well as the prevalence of dementia in K town of southern Wakayama with an especially high incidence of ALS noted previously. We observed that an upsurge in the incidence of ALS awaits recognition and that the onset of PDC was not confirmed. Furthermore, a dementia screening survey in K town revealed that the prevalence of dementia in K town is not higher than that estimated in other studies in Japan.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2018 2017 2016

All Journal Article (1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] 紀伊ALSにおける免疫組織化学的検討2018

    • Author(s)
      辻郁在、中山宜昭、綾木孝、廣西昌也、伊東秀文
    • Journal Title

      和歌山医学

      Volume: 69 Pages: 14-19

    • NAID

      40021533620

    • Related Report
      2017 Annual Research Report
  • [Presentation] 紀伊ALS/PDC多発地域における認知症有病率2018

    • Author(s)
      廣西昌也
    • Organizer
      日本神経学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Updated epidemiological assessment of amyotrophic lateral sclerosis in Wakayama prefecture, Japan, using data from the Japanese Specified disease treatment research program.2017

    • Author(s)
      Hironishi M, Nakayama Y, Kihira T, Yoshida S, Ito H
    • Organizer
      The 23th World Congress of Neurology, Kyoto, Japan, 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 和歌山県における筋萎縮性側索硬化症の発症状況と発症関連遺伝子に関する研究2016

    • Author(s)
      廣西昌也, 中山宜昭, 紀平為子, 吉田宗平, 森野豊之, 川上秀史, 伊東秀文
    • Organizer
      日本神経学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 和歌山県における筋萎縮性側索硬化症の発症状況と発症関連遺伝子に関する研究2016

    • Author(s)
      廣西昌也, 中山宜昭, 紀平為子, 吉田宗平, 森野豊之, 川上秀史, 伊東秀文
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸
    • Related Report
      2016 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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