| Project/Area Number |
26460757
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Chiba Cancer Center (Research Institute) |
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Principal Investigator |
MIKAMI Haruo 千葉県がんセンター(研究所), がん予防センター, 部長 (10332355)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGASE Hiroki 千葉県がんセンター(研究所), 所長 (90322073)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 癌 / 遺伝学 / 遺伝子 / ゲノム / 人間生活環境 |
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| Outline of Final Research Achievements |
We conducted the next-gen sequencing approach to identify risk-associated genetic variants primarily in a cancer risk population. In cohort sample, 40 stomach cancer cases and 43 colon cancer cases were identified and considered as a cancer risk group, while 33 healthy individuals who did not develop any cancer by 70 years old were used as a low-risk control. The study revealed to identify more frequent unknown / non-synonymous germ-line mutations including non-sense variants in the risk group. We have identified potential functional non-synonymous germ-line mutations in 2 genes for risk of stomach cancer, 3 genes for colon cancer.
Cancer risk markers identified in this study can be useful to apply prevention, health check-up invitation, early-diagnosis for cancer in a regional population. Further analyses are necessary to demonstrate mechanisms involved in the cancer risk, which may be contributed by polymorphic germ-line alleles identified in this study.
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