| Project/Area Number |
26460760
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
川村 孝 京都大学, 環境安全保健機構, 教授 (10252230)
若井 建志 名古屋大学, 医学系研究科, 教授 (50270989)
玉腰 暁子 北海道大学, 医学研究科, 教授 (90236737)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 高齢者 / 長寿 / コーホート研究 / 生活習慣 / コーホート |
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| Outline of Final Research Achievements |
Alpha-klotho (Klotho) has been identified as a biomarker of aging. Angiopoietin-like protein 2 (Angptl2) has also been identified as an indicator of chronic inflammation. However, evidence for an association between Klotho and Angptl2 with mortality has not been established. We conducted a stratified case-cohort study using data from the NISSIN Project, a prospective cohort study. A total of 2,851 participants aged 64/65 years at baseline formed the original cohort, from 1996 to 2005. A sub-cohort of 714 participants and 374 deaths (88 deaths within the sub-cohort) were analyzed. A weighted Cox proportional hazard model was used to evaluate the association of Klotho and Angptl2 with mortality. The median (25-75 percentile) concentration of Klotho and Angptl2 was 670 (540.0-883.5) pg/mL, 3.76 (3.07-4.57) ng/mL, respectively. There is a positive association between Angptl2 and mortality, whereas no association was found between Klotho and mortality.
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