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Association of alpha-klotho and angiopoietin-like protein 2 with mortality in the younger elderly

Research Project

Project/Area Number 26460760
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionHokkaido University

Principal Investigator

UKAWA SHIGEKAZU  北海道大学, 医学研究科, 助教 (40706751)

Co-Investigator(Kenkyū-buntansha) 川村 孝  京都大学, 環境安全保健機構, 教授 (10252230)
若井 建志  名古屋大学, 医学系研究科, 教授 (50270989)
玉腰 暁子  北海道大学, 医学研究科, 教授 (90236737)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords高齢者 / 長寿 / コーホート研究 / 生活習慣 / コーホート
Outline of Final Research Achievements

Alpha-klotho (Klotho) has been identified as a biomarker of aging. Angiopoietin-like protein 2 (Angptl2) has also been identified as an indicator of chronic inflammation. However, evidence for an association between Klotho and Angptl2 with mortality has not been established. We conducted a stratified case-cohort study using data from the NISSIN Project, a prospective cohort study. A total of 2,851 participants aged 64/65 years at baseline formed the original cohort, from 1996 to 2005. A sub-cohort of 714 participants and 374 deaths (88 deaths within the sub-cohort) were analyzed. A weighted Cox proportional hazard model was used to evaluate the association of Klotho and Angptl2 with mortality. The median (25-75 percentile) concentration of Klotho and Angptl2 was 670 (540.0-883.5) pg/mL, 3.76 (3.07-4.57) ng/mL, respectively. There is a positive association between Angptl2 and mortality, whereas no association was found between Klotho and mortality.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (9 results)

All 2017 2016 2015 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (5 results) (of which Int'l Joint Research: 2 results) Remarks (1 results)

  • [Journal Article] Leisure-time physical activity and risk of disability incidence: A 12-year prospective cohort study among the young elderly of the same age at baseline2017

    • Author(s)
      Matsunaga T, Naito M, Wakai K, Ukawa S, Zhao W, Okabayashi S, Ando M, Kawamura T, Tamakoshi A
    • Journal Title

      J Epidemio

      Volume: 印刷中

    • NAID

      130006139940

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of gait speed with mortality among the Japanese elderly in the New Integrated Suburban Seniority Investigation Project: a prospective cohort study.2015

    • Author(s)
      Zhao W, Ukawa S, Tsushita K, Kawamura T, Wakai K, Ando M, Tamakoshi A
    • Journal Title

      Age and Ageing

      Volume: 44 Issue: 1 Pages: 153-157

    • DOI

      10.1093/ageing/afu121

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between falls and depressive symptoms or visual impairment among Japanese young-old adults2015

    • Author(s)
      Kojima R, Ukawa S, Ando M, Kawamura T, Wakai K, Tsushita M, Tamakoshi A
    • Journal Title

      Geriatr Gerontol Int

      Volume: 未定 Issue: 3 Pages: 384-391

    • DOI

      10.1111/ggi.12487

    • NAID

      120005981353

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 高齢者における睡眠時間とその後の要介護状態との関連:NISSIN Project2017

    • Author(s)
      張琳, 鵜川重和, 趙文静, 若井建志, 津下一代, 岡林里枝, 川村孝, 安藤昌彦, 玉腰暁子
    • Organizer
      第23回日本行動医学会学術総会
    • Place of Presentation
      沖縄科学技術大学院大学(沖縄県恩納村)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 慢性腎臓病の有無別血漿中Angptl2濃度と高尿酸血症との関連 (NISSIN Project)2017

    • Author(s)
      鵜川重和, 森永潤, 尾池雄一, 若井建志, 岡林里枝, 趙文静, 津下一代, 安藤昌彦, 川村孝, 玉腰暁子
    • Organizer
      第27回日本疫学会学術総会
    • Place of Presentation
      ベルクラシック甲府(山梨県甲府市)
    • Year and Date
      2017-01-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Dietary Pattern and All-cause Mortality in the Young-elderly Japanese in the New Integrated Suburban Seniority Investigation Project: A Prospective Cohort Study2016

    • Author(s)
      Zhao W, Ukawa S, Okada E, Kawamura T, Wakai K, Ando M, Tamakoshi A
    • Organizer
      The Gerontological Society of America's 69th Annual Scientific Meeting
    • Place of Presentation
      New Orleans, U.S.A.
    • Year and Date
      2016-11-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高齢者のAdiponectin濃度と総死亡の関連 NISSIN Projectより2016

    • Author(s)
      小島令嗣, 鵜川重和, 趙文静, 津下一代, 岡林里枝, 若井建志, 鈴木康司, 玉腰暁子
    • Organizer
      第75回日本公衆衛生学会総会
    • Place of Presentation
      グランフロント大阪(大阪府大阪市)
    • Year and Date
      2016-10-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] Factors associated with the decline in competence of daily living among Japanese early-elderly: findings from the NISSIN prospective cohort study2016

    • Author(s)
      Okabayashi S, Kawamura T, Tamakoshi A, Ukawa S, Wakai K, Ando M, Tsushita K, Ohira H
    • Organizer
      48th Asia-Pacific Consortium for Public Health Conference
    • Place of Presentation
      帝京大学(東京都板橋区)
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 高齢者の健康障害予防に関する研究(NISSIN Project)

    • URL

      http://publichealth.med.hokudai.ac.jp/research

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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