| Project/Area Number |
26460761
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中路 重之 弘前大学, 医学研究科, 教授 (10192220)
下山 克 弘前大学, 医学研究科, 准教授 (50312492)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | Helicobacter pylori / 骨減少症 / 胃粘膜萎縮 / 血清エストラジオール濃度 / カルシウム摂取量 / 生活習慣 / ヘリコバクターピロリ感染 / 骨密度 / エストロゲン濃度 / 血清ペプシノーゲン |
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| Outline of Final Research Achievements |
In Japanese males, bivariate and multivariate analyses revealed that only age was significantly different between subjects with or without osteopenia. H. pylori infection is not a risk for osteopenia. In Japanese females, bivariate analysis showed H. pylori infection was associated with osteopenia. However, multivariate logistic regression analysis revealed that H. pylori infection was not significantly associated with osteopenia. Age, BMI, last educational level, serum level of estradiol and calcium intake were significantly associated with osteopenia. Furthermore, no significant association was found between gastric mucosal atrophy and osteopenia in multivariate logistic regression. Presence of significant confounding factors in the multivariate analysis might preclude the association between H. pylori infection and osteopenia.
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