| Project/Area Number |
26460763
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
SANKAI Tomoko 筑波大学, 医学医療系, 准教授 (10241829)
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| Co-Investigator(Renkei-kenkyūsha) |
ISO Hiroyasu 大阪大学, 医学系研究院, 教授 (50223053)
KITAMURA Akihiko 東京都健康長寿医療センター, 研究所, 研究部長 (80450922)
YAMAGISHI Kazumasa 筑波大学, 医学医療系, 准教授 (20375504)
KIYAMA Masahiko 大阪がん循環器病予防センター, 副所長 (10450925)
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| Research Collaborator |
SATA Mizuki
MATSUMURA Takumi
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 出血性脳血管疾患 / 脳内出血 / くも膜下出血 / 可溶性Fas / IGF-1 / 疫学 / コホート内症例対照研究 / 細胞増殖因子 / 可溶性Fas（sFas) / sFas / アポトーシス / IGF-Ⅰ / 危険因子 |
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| Outline of Final Research Achievements |
To investigate the effects of sFas and IGF-1 on the onset and prognosis of hemorrhagic cerebrovascular disease and to confirm the possibility as new biomarkers, we measured them serum samples between two groups, 118 hemorrhagic cerebrovascular disease onset group of all ages and 236 non-onset control group matched for sex, age, area of residence and year of serum storage in a nested case-control study under three Japanese prospective cohorts within about nine thousand men and women. As a result, univariate and multivariate analysis showed that low serum IGF-1 levels may be associated with high onset risk of subarachnoid hemorrhage, suggesting a potential role of proliferative factors in the development of subarachnoid hemorrhage.
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