A prospective study on the association between declined autonomic nervous system function and onset of diabetes

• Project/Area Number: 26460767
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Ehime University
• Principal Investigator: Saito Isao 愛媛大学, 医学系研究科, 教授 (90253781)
• Co-Investigator(Kenkyū-buntansha): 山内 加奈子 愛媛大学, 教育学部, 研究員 (20510283) ; 加藤 匡宏 愛媛大学, 教育学部, 准教授 (60325363)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 疫学 / 糖尿病 / 自律神経系機能 / 心拍変動 / メタボリックシンドローム

Outline of Final Research Achievements

We examined the association of heart rate variability (HRV), which expresses an autonomic nervous system function, with insulin resistance and incident diabetes in a general population. Declined HRV was related to the accumulation of each risk factor of waist circumstance, blood pressure, HDL cholesterol, triglycerides, and fasting glucose; and an increase in percentage of the metabolic syndrome. During the follow-up of five years, we identified 58 new diabetes onsets among 1001 participants, but sex and age-adjusted odds ratios of low HRV for diabetes onset were not significant. Decreased parasympathetic nervous system function, which elevated the sympathetic nervous activity, was associated with increased insulin resistance, low insulin sensitivity, and presence of the metabolic syndrome.

Research Products

• [Journal Article] Low heart rate variability and sympathetic dominance modifies the association between insulin resistance and the metabolic syndrome: the Toon Health Study (2017)
  • Author(s): Saito I,Maruyama K, Eguchi E, Kato T, Kawamura R, Takata Y, Onuma H, Osawa H, Tanigawa T.
  • Journal Title: Circ J Volume: in press Pages: 0000-0000
  • NAID: 130006099883
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Impact of heart rate variability on C-reactive protein concentrations in Japanese adult nonsmokers: The Toon Health Study. (2016)
  • Author(s): Saito I., Hitsumoto S., Maruyama K., Eguchi E., Kato T., Okamoto A., Kawamura R., Takata Y., Nishida W., Nishimiya T., Onuma H., Osawa H., Tanigawa T.
  • Journal Title: Atherosclerosis Volume: 244 Pages: 79-85
  • DOI: 10.1016/j.atherosclerosis.2015.10.112
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Heart Rate Variability, Insulin Resistance, and Insulin Sensitivity in Japanese Adults: The Toon Health Study (2015)
  • Author(s): Saito I., Hitsumoto S., Maruyama K., Nishida W., Eguchi E., Kato T., Kawamura R., Takata Y., Onuma H., Osawa H., Tanigawa T.
  • Journal Title: Journal of Epidemiology Volume: 25 Issue: 9 Pages: 583-591
  • DOI: 10.2188/jea.JE20140254
  • NAID: 130005096832
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Heart rate variability, insulin resistance and insulin sensitivity in Japanese adults: the Toon Health Study. (2015)
  • Author(s): Saito I, Hitsumoto S, Maruyama K, Nishida W, Eguchi E, Kato T, Kawamura R, Takata Y, Onuma H, Osawa H, Tanigawa T.
  • Journal Title: J Epidemiol Volume: in press Pages: 000-000
  • NAID: 130005096832
  • Peer Reviewed