The association between sleep-disordered breathing and prognosis among patients with liver diseases:

• Project/Area Number: 26460768
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Ehime University
• Principal Investigator: Furukawa Shinya 愛媛大学, 医学系研究科, 准教授 (60444733)
• Co-Investigator(Kenkyū-buntansha): 廣岡 昌史 愛媛大学, 医学部附属病院, 准教授 (30432785) ; 日浅 陽一 愛媛大学, 医学系研究科, 教授 (70314961) ; 谷川 武 順天堂大学, 医学(系)研究科(研究院), 教授 (80227214)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 肝疾患 / 睡眠呼吸障害 / 肝細胞癌 / 睡眠時無呼吸症候群 / 肝細胞ガン / 発がん / 睡眠時間

Outline of Final Research Achievements

85 patients with hepatocellular cancer were enrolled in this study (69 male patients, 53 -83 years). A self-administered questionnaire was used to assess Pittsburgh Sleep Quality Index, Epworth Sleepness Scale, nocturia, drinking habits, smoking habits, eating habits, and exercise habits. The stage of hepatocellular cancer, and liver function was collected based on medical record.
The assessment of sleep-disordered breathing (SDB): A pulse oximeter (PULSOX 3Si; Minolta Co., Osaka, Japan) was attached to the left wrist. The severity of sleep breathing disorder was defined by the 3% oxygen desaturation index level: normal, less than five events per hour; SDB, 5 or more; events per hour; moderate to severe SBD 15 or more; events per hour. We would estimate the association between the severity of SBD and prognosis of hepatocellular cancer after data cleaning.

Research Products

• [Journal Article] Significance of exercise in nonalcoholic fatty liver disease in men: a community-based large cross-sectional study. (2015)
  • Author(s): Miyake T, Kumagi T, Hirooka M, Furukawa S, Kawasaki K, Koizumi M, Todo Y, Yamamoto S, Nunoi H, Tokumoto Y, Ikeda Y, Abe M, Kitai K, Matsuura B, Hiasa Y.
  • Journal Title: J Gastroenterol Volume: 50 Issue: 2 Pages: 230-237
  • DOI: 10.1007/s00535-014-0959-6
  • Peer Reviewed / Open Access
• [Journal Article] Diminished immune response to vaccinations in a murine model of obesity: Role of myeloid-derived suppressor cells. (2015)
  • Author(s): Chen S, Akbar SMF, Miyake T, Abe M, Al-Mahtab M, Furukawa S, Matsuura B, Hiasa Y, Onji M.
  • Journal Title: Obes Res Clin Pract Volume: 9 Issue: 1 Pages: 35-44
  • DOI: 10.1016/j.orcp.2013.12.006
  • Peer Reviewed / Open Access
• [Journal Article] The impact of masticatory ability as evaluated by salivary flow rates on obesity in Japanese: The Toon health study (2015)
  • Author(s): Maruyama K, Nishioka S, Miyoshi N, Higuchi K, Mori H, Tanno S, Tomooka K, Eguchi E, Furukawa S, Saito I, Sakurai S, Nishida W, Osawa H, Tanigawa T.
  • Journal Title: Obesity Volume: 23 Issue: 6 Pages: 1296-302
  • DOI: 10.1002/oby.21071
  • Peer Reviewed
• [Journal Article] Short sleep duration reduces the risk of nonalcoholic fatty liver disease onset in men: a community-based longitudinal cohort study. (2014)
  • Author(s): Miyake T, Kumagi T, Furukawa S, Hirooka M, Kawasaki K, Koizumi M, Todo Y, Yamamoto S, Tokumoto Y, Ikeda Y, Abe M, Kitai K, Matsuura B, Hiasa Y.
  • Journal Title: J Gastroenterol Volume: Epub Issue: 5 Pages: 583-9
  • DOI: 10.1007/s00535-014-0989-0
  • Peer Reviewed / Open Access