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The association between sleep-disordered breathing and prognosis among patients with liver diseases:

Research Project

Project/Area Number 26460768
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionEhime University

Principal Investigator

Furukawa Shinya  愛媛大学, 医学系研究科, 准教授 (60444733)

Co-Investigator(Kenkyū-buntansha) 廣岡 昌史  愛媛大学, 医学部附属病院, 准教授 (30432785)
日浅 陽一  愛媛大学, 医学系研究科, 教授 (70314961)
谷川 武  順天堂大学, 医学(系)研究科(研究院), 教授 (80227214)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords肝疾患 / 睡眠呼吸障害 / 肝細胞癌 / 睡眠時無呼吸症候群 / 肝細胞ガン / 発がん / 睡眠時間
Outline of Final Research Achievements

85 patients with hepatocellular cancer were enrolled in this study (69 male patients, 53 -83 years). A self-administered questionnaire was used to assess Pittsburgh Sleep Quality Index, Epworth Sleepness Scale, nocturia, drinking habits, smoking habits, eating habits, and exercise habits. The stage of hepatocellular cancer, and liver function was collected based on medical record.
The assessment of sleep-disordered breathing (SDB): A pulse oximeter (PULSOX 3Si; Minolta Co., Osaka, Japan) was attached to the left wrist. The severity of sleep breathing disorder was defined by the 3% oxygen desaturation index level: normal, less than five events per hour; SDB, 5 or more; events per hour; moderate to severe SBD 15 or more; events per hour. We would estimate the association between the severity of SBD and prognosis of hepatocellular cancer after data cleaning.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2015 2014

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results)

  • [Journal Article] Significance of exercise in nonalcoholic fatty liver disease in men: a community-based large cross-sectional study.2015

    • Author(s)
      Miyake T, Kumagi T, Hirooka M, Furukawa S, Kawasaki K, Koizumi M, Todo Y, Yamamoto S, Nunoi H, Tokumoto Y, Ikeda Y, Abe M, Kitai K, Matsuura B, Hiasa Y.
    • Journal Title

      J Gastroenterol

      Volume: 50 Issue: 2 Pages: 230-237

    • DOI

      10.1007/s00535-014-0959-6

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diminished immune response to vaccinations in a murine model of obesity: Role of myeloid-derived suppressor cells.2015

    • Author(s)
      Chen S, Akbar SMF, Miyake T, Abe M, Al-Mahtab M, Furukawa S, Matsuura B, Hiasa Y, Onji M.
    • Journal Title

      Obes Res Clin Pract

      Volume: 9 Issue: 1 Pages: 35-44

    • DOI

      10.1016/j.orcp.2013.12.006

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The impact of masticatory ability as evaluated by salivary flow rates on obesity in Japanese: The Toon health study2015

    • Author(s)
      Maruyama K, Nishioka S, Miyoshi N, Higuchi K, Mori H, Tanno S, Tomooka K, Eguchi E, Furukawa S, Saito I, Sakurai S, Nishida W, Osawa H, Tanigawa T.
    • Journal Title

      Obesity

      Volume: 23 Issue: 6 Pages: 1296-302

    • DOI

      10.1002/oby.21071

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Short sleep duration reduces the risk of nonalcoholic fatty liver disease onset in men: a community-based longitudinal cohort study.2014

    • Author(s)
      Miyake T, Kumagi T, Furukawa S, Hirooka M, Kawasaki K, Koizumi M, Todo Y, Yamamoto S, Tokumoto Y, Ikeda Y, Abe M, Kitai K, Matsuura B, Hiasa Y.
    • Journal Title

      J Gastroenterol

      Volume: Epub Issue: 5 Pages: 583-9

    • DOI

      10.1007/s00535-014-0989-0

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access

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Published: 2014-04-04   Modified: 2018-03-22  

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