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The association of retinal thickness measurements with cognitive impairment in a Japanese population

Research Project

Project/Area Number 26460778
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Epidemiology and preventive medicine
Research Institution独立行政法人国立病院機構(東京医療センター臨床研究センター)

Principal Investigator

SASAKI MARIKO  独立行政法人国立病院機構(東京医療センター臨床研究センター), その他部局等, 研究員 (60276342)

Research Collaborator TSUBOTA KAZUO  慶應義塾大学, 大学病院, 教授
SAWADA NORIE  国立がん研究センター, 疫学研究部, 室長
MIMURA MASARU  慶應義塾大学, 大学病院, 教授
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords認知症 / 網膜厚 / 光干渉断層計 / コホート研究 / 眼科検診 / OCT
Outline of Final Research Achievements

In this cross-sectional population based study, 1287 participants underwent cognitive assessment to diagnose as normal, mild cognitive impairment (MCI) or dementia. Optical coherence tomography (OCT) measurements such as macular retinal thickness, macular inner retinal layer thickness and peripapillary retinal nerve fiber layer (RNFL) thickness were calculated. After adjusting for age, gender and refraction, thinner macular retinal thickness and macular inner layer retinal thickness were associated with an increased likelihood of having dementia, whereas no association was found with having MCI. There was no association of peripapillary RNFL thickness with either having MCI or dementia.
Our results suggest that OCT could be a potentially useful diagnostic tool in the evaluation of dementia. Longitudinal studies are warranted to confirm this observation.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2016

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Int'l Joint Research: 2 results) Book (1 results)

  • [Journal Article] 糖尿病網膜症の疫学2016

    • Author(s)
      佐々木真理子
    • Journal Title

      あたらしい眼科

      Volume: 33 Pages: 1261-1268

    • Related Report
      2016 Annual Research Report
  • [Journal Article] One-year outcome of intravitreal aflibercept injection for age-related macular degeneration resistant to ranibizumab: Rapid morphologic recovery and subsequent visual improvement2016

    • Author(s)
      Toshiaki Hirakata
    • Journal Title

      Clinical Ophthalmology

      Volume: 26 Pages: 969-977

    • DOI

      10.2147/opth.s101596

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional Visual Acuity in Age-Related Macular Degeneration.2016

    • Author(s)
      Tomita Y, Nagai Y, Suzuki M, Shinoda H, Uchida A, Mochimaru H, Izumi-Nagai K, Sasaki M, Tsubota K, Ozawa Y
    • Journal Title

      Optometry and Vision Science

      Volume: 93 Issue: 1 Pages: 70-76

    • DOI

      10.1097/opx.0000000000000755

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Prevalence of diabetic retinopathy by the glycemic and blood pressure levels in an adult Japanese population: the Chikusei Eye Study2016

    • Author(s)
      Mariko Sasaki
    • Organizer
      The Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2016-05-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The association between the presence of epiretinal membrane and nerve fiber layer defect in an adult Japanese population: The Chikusei Eye Study2016

    • Author(s)
      Atsuro Uchida
    • Organizer
      The Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2016-05-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 住民検診データによる特発性黄斑上膜と緑内障性眼底所見の関連の検討:筑西眼科研究2016

    • Author(s)
      内田敦郎
    • Organizer
      日本眼科学会
    • Place of Presentation
      仙台
    • Year and Date
      2016-04-07
    • Related Report
      2016 Annual Research Report
  • [Book] ブルーライトテキストブック2016

    • Author(s)
      佐々木真理子
    • Total Pages
      211
    • Publisher
      金原出版
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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