| Project/Area Number |
26460779
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Showa University |
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Principal Investigator |
Koba Shinji 昭和大学, 医学部, 教授 (20276546)
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| Co-Investigator(Kenkyū-buntansha) |
横田 裕哉 昭和大学, 医学部, 講師 (00465105)
正司 真 昭和大学, 医学部, 講師 (50384392)
角田 史敬 昭和大学, 医学部, 講師 (60384393)
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| Research Collaborator |
Kokaze Akatsuki
Ogawa Mutsumi
Takao Tetsuya
Shimizu Fumiko
Takada Akikazu
Motohashi Miki
Harris William S
Furuyama Fumiaki
Arai Ken
Toyosaki Eiji
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| Project Period (FY) |
2014-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 多価不飽和脂肪酸 / トランス脂肪酸 / 急性冠症候群 / 食習慣 / 野菜 / 魚介類 / 脂質 / 食事歴質問票 / コレステロール / 心不全 / アミノ酸 / 脂肪酸 / 栄養 / 食事 / 必須アミノ酸 / うっ血性心不全 / 食物摂取頻度調査 / トリプトファン / 動脈硬化 |
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| Outline of Final Research Achievements |
Plasma fatty acid (FA) composition including trans FA (TFA) (as determined by gas chromatography) and dietary pattern immediately before the blood sampling (as determined using self-administered diet history questionnaire) were analyzed in acute coronary syndrome (ACS) patients, mean age of 62 on hospital admission and compared to that of age-adjusted healthy men. Total FA and TFA levels were similar between ACS and controls. Linoleic trans isomers, industrially-produced TFA were significantly higher, and the levels of palmitelaidic acid, ruminant-derived TFA (R-TFA), arachidonic acid, and n-3 polyunsaturated FA（n3-PUFA）were significantly lower in ACS patients. R-TFA was significantly directly associated with n3-PUFA. ACS patients took significantly more sugar, confectionery, fat and oils, and significantly less potatoes, vegetables, egg, and sea food, resulting in lower potassium, calcium, iron, cholesterol, and n3-PUFA, in spite of similar energy intake compared with the control.
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| Academic Significance and Societal Importance of the Research Achievements |
ACS患者は同年齢の健康人と比較し、芋類、野菜類、魚介類の摂取量が少なく、その結果カリウム、カルシウム、n3系多価不飽和脂肪酸(n3-PUFA)の摂取量が少なかった。ACS患者で卵類およびコレステロール摂取量はむしろ少なく、砂糖類、菓子類や油脂類の摂取量は多かった。ACSで工業型トランス脂肪酸(TFA)濃度は有意に高値であったが、天然型TFA、n3-PUFAおよびn6-PUFAの血中濃度が有意に低値であった。天然型TFA濃度がn3-PUFA濃度と正相関を示した。ACS予防のためには天然型TFA、芋類、野菜、魚介類を積極的に摂取すべきである。これらは新知見であり、今後さらなる検討が必要である。
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