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Cardio-Ankle Vascular Index (CAVI) as an Indicator of Coronary Events: A 5-Year Prospective Study

Research Project

Project/Area Number 26460781
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionToho University

Principal Investigator

SAIKI Atsuhito  東邦大学, 医学部, 准教授 (70338854)

Co-Investigator(Kenkyū-buntansha) 龍野 一郎  東邦大学, 医学部, 教授 (80282490)
白井 厚治  東邦大学, 医学部, 名誉教授 (00150269)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords血管機能検査 / 社会医学 / CAVI / 冠動脈イベント / 動脈硬化
Outline of Final Research Achievements

We investigated whether CAVI, an arterial stiffness marker, independently predicts future cardiovascular events in subjects with metabolic disorders. 1003 subjects with metabolic disorders were followed prospectively. During the observation period (6.7±1.6 years), 90 subjects had new-onset myocardial infarction or angina pectoris confirmed by angiography. All subjects were stratified into quartiles by baseline CAVI (Q1: CAVI -8.27, Q2: CAVI 8.28-9.19, Q3: CAVI 9.20-10.08, Q4: CAVI 10.09-). Age, male ratio and future cardiovascular events increased as CAVI quartile became higher. In Cox proportional hazards regression analysis, the factors independently associated with higher risk of future cardiovascular events were every 1.0 increment of CAVI, male gender, smoking, diabetes mellitus, and hypertension. In individuals with metabolic disorders, CAVI was a predictor of future cardiovascular events, independent of traditional coronary risk factors.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (27 results)

All 2017 2016 2015 2014

All Journal Article (7 results) (of which Peer Reviewed: 6 results,  Open Access: 6 results,  Acknowledgement Compliant: 1 results) Presentation (20 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] The Effect of Nitroglycerin on Arterial Stiffness of the Aorta and the Femoral-Tibial Arteries2017

    • Author(s)
      Yamamoto T, Shimizu K, Takahashi M, Tatsuno I, Shirai K.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 24 Issue: 10 Pages: 1048-1057

    • DOI

      10.5551/jat.38646

    • NAID

      130006110243

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inverse relationship of cardioankle vascular index with BMI in healthy Japanese subjects: a cross-sectional study.2016

    • Author(s)
      Nagayama D, Imamura H, Sato Y, Yamaguchi T, Ban N, Kawana H, Ohira M, Saiki A, Shirai K, Tatsuno I
    • Journal Title

      Journal of Vascular Health and Risk Management

      Volume: 13 Pages: 1-9

    • DOI

      10.2147/vhrm.s119646

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] INVERSE RELATIONSHIP BETWEEN CARDIO-ANKLE VASCULAR INDEX (CAVI) AND BODY MASS INDEX IN HEALTHY JAPANESE SUBJECTS: A CROSS-SECTIONAL STUDY.2016

    • Author(s)
      Nagayama D, Watanabe R, Watanabe Y, Imamura H, Sato Y, Yamaguchi T, Ban N, Kawana H, Ohira M, Saiki A, Shirai K, Tatsuno I.
    • Journal Title

      Journal of Hypertension

      Volume: 34 Suppl 1 Issue: Supplement 1 Pages: e73-e73

    • DOI

      10.1097/01.hjh.0000500040.08261.74

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Role of a Novel Arterial Stiffness Parameter, Cardio-Ankle Vascular Index (CAVI), as a Surrogate Marker for Cardiovascular Diseases2016

    • Author(s)
      Saiki A, Sato Y, Watanabe R, Watanabe Y, Imamura H, Yamaguchi T, Ban N, Kawana H, Nagumo A, Nagayama D, Ohira M, Endo K, Tatsuno I.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 23 Issue: 2 Pages: 155-168

    • DOI

      10.5551/jat.32797

    • NAID

      130005122036

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] High serum uric acid is associated with increased cardio-ankle vascular index (CAVI) in healthy Japanese subjects: A cross-sectional study2015

    • Author(s)
      Nagayama D, Yamaguchi T, Saiki A, Imamura H, Sato Y, Ban N, Kawana H, Nagumo A, Shirai K, Tatsuno I
    • Journal Title

      Atherosclerosis

      Volume: 239 Pages: 163-168

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cardio-Ankle Vascular Index is Independently Associated with Future Cardiovascular Events in Outpatients with Metabolic Disorders.2015

    • Author(s)
      Sato Y, Nagayama D, Saiki A, Watanabe R, Watanabe Y, Imamura H, Yamaguchi T, Ban N, Kawana H, Nagumo A, Ohira M, Endo K, Kurosu T, Tomaru T, Shirai K, Tatsuno I.
    • Journal Title

      J Atheroscler Thromb

      Volume: Epub ahead of print

    • NAID

      130005149018

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CAVI as an Indicator of Coronary Events: A Prospective Study2014

    • Author(s)
      Saiki A, Sato Y, Tatsuno I, Shirai K
    • Journal Title

      CAVI Now & Future

      Volume: 3 Pages: 29-33

    • Related Report
      2014 Research-status Report
  • [Presentation] CAVIは何を見ているか? ~糖尿病性血管障害~2017

    • Author(s)
      齋木厚人
    • Organizer
      血管弾性能(CAVI)でここまでわかる
    • Place of Presentation
      フクダ電子南関東販売(千葉市中央区)
    • Year and Date
      2017-02-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Inverse Relationship between Cardio-Ankle Vascular Index (CAVI) and Body Mass Index in healthy Japanese subjects: a cross-sectional study.2016

    • Author(s)
      Nagayama D, Watanabe R, Watanabe Y, Imamura H, Sato Y, Yamaguchi T, Ban N, Kawana H, Ohira M, Saiki A, Shirai K, Tatsuno I
    • Organizer
      HYPERTENSION SEOUL 2016 (26th Scientific Meeting of the ISH)
    • Place of Presentation
      COEX(Seoul, Korea)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 弾性機能からみた糖尿病性血管障害 ~動脈弾性能CAVIが拓く血管機能学~2016

    • Author(s)
      齋木厚人
    • Organizer
      第7回FRONTIER研究会
    • Place of Presentation
      シャングリ・ラ ホテル東京(東京都千代田区)
    • Year and Date
      2016-08-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] 悪性リンパ腫化学療法時の血管弾性能Cardio-Ankle Vascular Index (CAVI)の変動2016

    • Author(s)
      清水直美, 番典子, 田中翔, 渡邊怜奈, 渡邊康弘, 佐藤悠太, 今村榛樹, 山口崇, 川名秀俊, 大平征宏, 齋木厚人, 白井厚治, 龍野一郎
    • Organizer
      第48回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2016-07-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 日常診療で行える糖尿病大血管障害の診かた ~動脈弾性指標CAVIを用いて~2016

    • Author(s)
      齋木厚人
    • Organizer
      第2回病診連携カンファレンス
    • Place of Presentation
      APAホテルリゾート東京ベイ幕張(千葉県千葉市)
    • Year and Date
      2016-06-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] 肥満糖尿病が血管機能検査CAVIに及ぼす影響とそれに対するGLP-1受容体作動薬の効果2016

    • Author(s)
      齋木厚人
    • Organizer
      千葉GLP-1カンファレンス
    • Place of Presentation
      ホテルグリーンタワー幕張(千葉県千葉市)
    • Year and Date
      2016-06-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] EPA・DHAが血中脂質プロファイルと血管弾性に及ぼす影響~CAVIを用いた検討~2016

    • Author(s)
      山口崇, 渡辺怜奈, 渡邉康弘, 佐藤悠太, 今村榛樹,番典子, 川名秀俊, 南雲彩子, 齋木厚人, 龍野一郎
    • Organizer
      第113回日本内科学会総会・講演会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2016-04-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 非侵襲的動脈硬化検査をガイドラインにどう反映させるか β理論に基づいたCAVIの特性と 動脈硬化診療における有用性について2015

    • Author(s)
      齋木厚人
    • Organizer
      第47回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2015-07-09
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 日本人健常者において血清尿酸値はCardio-ankle vascular index(CAVI)と関連する2015

    • Author(s)
      永山大二, 渡邉康弘, 今村榛樹, 佐藤悠太, 山口崇, 番典子, 川名秀俊, 南雲彩子, 大平征宏, 齋木厚人, 龍野一郎
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      シーモールホール(山口県下関市)
    • Year and Date
      2015-05-21
    • Related Report
      2015 Research-status Report
  • [Presentation] ベザフィブラートが糖尿病合併高TG血症患者の血管弾性におよぼす影響2015

    • Author(s)
      山口崇, 渡邉怜奈, 渡邉康弘, 今村榛樹, 佐藤悠太, 番典子, 川名秀俊, 南雲彩子, 齋木厚人, 龍野一郎
    • Organizer
      第112回日本内科学会総会・講演会
    • Place of Presentation
      みやこめっせ(京都府京都市)
    • Year and Date
      2015-04-11
    • Related Report
      2015 Research-status Report
  • [Presentation] 高インスリン血症が頚動脈内中膜複合体厚および血管弾性指標CAVIに及ぼす影響2015

    • Author(s)
      渡邉怜奈, 山口崇, 今村榛樹, 佐藤悠太, 番典子, 川名秀俊, 南雲彩子, 大平征宏, 齋木厚人, 龍野一郎
    • Organizer
      第112回日本内科学会総会・講演会
    • Place of Presentation
      みやこめっせ(京都府京都市)
    • Year and Date
      2015-04-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 当院での減量手術前後における体組成・代謝変動の追跡調査2014

    • Author(s)
      山口崇, 渡邉康弘, 佐藤悠太, 今村榛樹, 番典子, 川名秀俊, 南雲彩子, 大平征宏, 齋木厚人, 大城崇司, 岡住慎一, 岡谷しのぶ, 白井厚治, 龍野一郎
    • Organizer
      第24回内分泌代謝UPDATE
    • Place of Presentation
      大宮ソニックシティ(埼玉県さいたま市)
    • Year and Date
      2014-11-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 当院における肥満外科治療後の体組成および代謝変動の推移に関する検討2014

    • Author(s)
      山口崇, 渡邉康弘, 佐藤悠太, 今村榛樹, 番典子, 川名秀俊, 南雲彩子, 大平征宏, 齋木厚人, 大城崇司, 岡住慎一, 岡谷しのぶ, 白井厚治, 龍野一郎
    • Organizer
      第35回日本肥満学会
    • Place of Presentation
      フェニックスシーガイアリゾート コンベンションセンター(宮崎県宮崎市)
    • Year and Date
      2014-10-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 高血糖が血管弾性に及ぼす影響 ~CAVIを用いた検討~2014

    • Author(s)
      渡邉康弘, 山口崇, 今村榛樹, 佐藤悠太, 番典子, 川名秀俊, 南雲彩子, 大平征宏, 齋木厚人, 白井厚治, 龍野一郎
    • Organizer
      第46回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2014-07-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 血清尿酸値とCardio-ankle vascular index (CAVI)の関連2014

    • Author(s)
      永山大二, 今村榛樹, 佐藤悠太, 山口崇, 番典子, 川名秀俊, 南雲彩子, 大平征宏, 齋木厚人, 龍野一郎
    • Organizer
      第46回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2014-07-10
    • Related Report
      2014 Research-status Report
  • [Presentation] クレメジンが糖尿病性早期腎症患者の腎機能および血管機能検査CAVIに及ぼす影響2014

    • Author(s)
      齋木 厚人, 今村 榛樹, 佐藤 悠太, 山口 崇, 番 典子, 川名 秀俊, 南雲 彩子, 永山 大二, 大平 征宏, 遠藤 渓, 白井 厚治, 龍野 一郎
    • Organizer
      第46回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2014-07-10
    • Related Report
      2014 Research-status Report
  • [Presentation] 当院における減量手術前後の体組成・代謝パラメータ変動に関する追跡調査 ~2年次報告~2014

    • Author(s)
      山口崇, 渡邉康弘, 佐藤悠太, 今村榛樹, 番典子, 川名秀俊, 南雲彩子, 大平征宏, 齋木厚人, 大城崇司, 岡住慎一, 岡谷しのぶ, 白井厚治, 龍野一郎
    • Organizer
      第32回日本肥満症治療学会学術集会
    • Place of Presentation
      滋賀県立県民交流センターピアザ淡海(滋賀県大津市)
    • Year and Date
      2014-07-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 血管壁弾性の指標であるcardio ankle vascular index: CAVIを用いた妊娠中の血管機能の評価2014

    • Author(s)
      佐々木泉, 永山大二, 横川桂, 安達知弘, 萬来めぐみ, 石田洋明, 高島明子, 竹下直樹, 木下俊彦, 龍野一郎
    • Organizer
      第87回日本内分泌学会学術総会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2014-04-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 血清尿酸値と血管弾性指標Cardio-ankle vascular index(CAVI)の関連2014

    • Author(s)
      永山大二, 今村 榛樹, 佐藤悠太, 山口崇, 番典子, 川名秀俊, 南雲彩子, 大平征宏, 齋木厚人, 龍野一郎
    • Organizer
      第87回日本内分泌学会学術総会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2014-04-25
    • Related Report
      2014 Research-status Report
  • [Presentation] 血管弾性指標CAVIと尿酸値の関連2014

    • Author(s)
      永山大二, 今村 榛樹, 佐藤悠太, 山口崇, 番典子, 川名秀俊, 南雲彩子, 大平征宏, 齋木厚人, 龍野一郎
    • Organizer
      第111回日本内科学会総会・講演会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2014-04-11
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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