| Project/Area Number |
26460788
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Kindai University |
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Principal Investigator |
YURA Akiko 近畿大学, 医学部, 講師 (80142595)
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| Co-Investigator(Kenkyū-buntansha) |
藤田 裕規 近畿大学, 医学部, 講師 (10330797)
伊木 雅之 近畿大学, 医学部, 教授 (50184388)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | リスク評価 / 骨折 / 骨粗鬆症 / 予防医学 |
|---|
| Outline of Final Research Achievements |
To test the validity of a fracture risk prediction model, FRAX, in Japanese men, we analyzed the data from 1805 men who had been followed for 5 years. Major osteoporotic fractures (MOFx) and morphometric vertebral fractures (vFx) were identified in 22 and 41 men, respectively, during the follow-up. Area under ROC curve of FRAX at baseline for predicting the risk of MOFx was 0.668 and was improved to 0.720 by adding trabecular bone score (TBS) and serum pentosidine levels to the model. AUC of FRAX for predicting vFx was 0.682. A model incorporating BMD, age and BMI showed a significantly greater AUC, 0.783, than FRAX alone, and was recommended to use to assess vFx.
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