Chort based Indivualized Risk Estimation By biomarkers and Machine Learning
Project/Area Number |
26460790
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Epidemiology and preventive medicine
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Research Institution | National Cardiovascular Center Research Institute |
Principal Investigator |
Kunihiro Nishimura 国立研究開発法人国立循環器病研究センター, 研究開発基盤センター, 室長 (70397834)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | コホート研究 / リスク予測 / 機械学習 / 虚血性心疾患 / バイオマーカー / MRI / 循環器病 / 脳卒中 / 心筋梗塞 / MACE |
Outline of Final Research Achievements |
We deveoped coronary heart disease (CHD) risk score, called Suita Score based on 10 years follo-up results from Suita study for praimary prevention. We also devoped the risk score for major cardiac disease( MACE) prediction score based on the follow-up data of 1920 prospective observaional cases with cariovascular diseases using machine learnig. We adopted ensemble learning with support vectors and random forests to predict 1 year MACE in the socondary prevention using around 40 rountinely used biomarkers in daily practices. The total acuracy was around 90% and it was reproudcible in validation data sets, with more precise prediction ability than existing MACE prediction model, such as GRACE socre.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Homogeneous Assays for LDL-C and HDL-C are Reliable in Both the Postprandial and Fasting State.2017
Author(s)
Miida T, Nishimura K, Hirayama S, Miyamoto Y, Nakamura M, Masuda D, Yamashita S, Ushiyama M, Komori T, Fujita N, Yokoyama S, Teramoto T.
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Journal Title
J Atheroscler Thromb
Volume: -
NAID
Related Report
Peer Reviewed
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[Journal Article] Development and validation of a score for evaluating comprehensive stroke care capabilities: J-ASPECT Study.2017
Author(s)
Kada A, Nishimura K, Nakagawara J, Ogasawara K, Ono J, Shiokawa Y, Aruga T, Miyachi S, Nagata I, Toyoda K, Matsuda S, Suzuki A, Kataoka H, Nakamura F, Kamitani S, Iihara K; J-ASPECT Study Collaborators..
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Journal Title
BMC Neurol.
Volume: 17
Pages: 46-46
Related Report
Peer Reviewed
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[Journal Article] Diabetes and lifetime risk of stroke and subtypes in an urban middle-aged population.2017
Author(s)
Turin TC, Okamura T, Rumana N, Afzal AR, Watanabe M, Higashiyama A, Nakao YM, Nakai M, Takegami M, Nishimura K, Kokubo Y, Okayama A, Miyamoto Y.
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Journal Title
J Diabetes Complications.
Volume: 31
Pages: 831-835
Related Report
Peer Reviewed
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[Journal Article] Impact of Acute Kidney Injury on In-Hospital Outcomes of Patients With Acute Myocardial Infarction - Results From the Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) Substudy.2017
Author(s)
Kuji S, Kosuge M, Kimura K, Nakao K, Ozaki Y, Ako J, Noguchi T, Yasuda S, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Nishimura K, Miyamoto Y, Ishihara M; J-MINUET Investigators..
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Journal Title
Circ J.
Volume: 81
Pages: 733-739
NAID
Related Report
Peer Reviewed
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[Journal Article] Honda Y, Nagai T, Ikeda Y, Sakakibara M, Asakawa N, Nagano N, Nakai M, Nishimura K, Sugano Y, Ohta-Ogo K, Asaumi Y, Aiba T, Kanzaki H, Kusano K, Noguchi T, Yasuda S, Tsutsui H, Ishibashi-Ueda H, Anzai T.2016
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[Journal Article] Impact of symptom presentation on in-hospital outcomes in patients with acute myocardial infarction.2016
Author(s)
Fujino M, Ishihara M, Ogawa H, Nakao K, Yasuda S, Noguchi T, Ozaki Y, Kimura K, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Uematsu M, Ako J, Nakai M, Nishimura K, Miyamoto Y; J-MINUET Investigators.
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Journal Title
J Cardiol.
Volume: 5087
Pages: 30240-30244
Related Report
Peer Reviewed
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[Journal Article] Circulating Omega-6, But Not Omega-3 Polyunsaturated Fatty Acids, Are Associated with Clinical Outcomes in Patients with Acute Decompensated Heart Failure.2016
Author(s)
Nagai T, Honda Y, Sugano Y, Nishimura K, Nakai M, Honda S, Iwakami N, Okada A, Asaumi Y, Aiba T, Noguchi T, Kusano K, Ogawa H, Yasuda S, Anzai T; NaDEF investigators..
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] The Current Status of Cardiovascular Medicine in Japan - Analysis of a Large Number of Health Records From a Nationwide Claim-Based Database, JROAD-DPC.2016
Author(s)
Yasuda S1, Nakao K, Nishimura K, Miyamoto Y, Sumita Y, Shishido T, Anzai T, Tsutsui H, Ito H, Komuro I, Saito Y, Ogawa H; on the behalf of JROAD Investigators.
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Journal Title
Circ J.
Volume: 80
Pages: 2327-2335
NAID
Related Report
Peer Reviewed
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[Journal Article] Prognostic impact of chronic total coronary occlusion on long-term outcomes in implantable cardioverter-defibrillator recipients with ischaemic heart disease.2016
Author(s)
Nishikawa T, Fujino M, Nakajima I, Asaumi Y, Kataoka Y, Anzai T, Kusano K, Noguchi T, Goto Y, Nishimura K, Miyamoto Y, Kiso K, Yasuda S.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Current Trends and Healthcare Resource Usage in the Hospital Treatment of Primary Malignant Brain Tumor in Japan: A National Survey Using the Diagnostic Procedure Combination Database (J-ASPECT Study-Brain Tumor).2016
Author(s)
Yoshimoto K, Kada A, Kuga D, Hatae R, Murata H, Akagi Y, Nishimura K, Kurogi R, Nishimura A, Hata N, Mizoguchi M, Sayama T, Iihara K.
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Journal Title
Neurol Med Chir (Tokyo).
Volume: 56
Pages: 664-673
NAID
Related Report
Peer Reviewed
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[Journal Article] Validation of the Coronary Artery Bypass Graft SYNTAX Score (Synergy Between Percutaneous Coronary Intervention With Taxus) as a Prognostic Marker for Patients With Previous Coronary Artery Bypass Graft Surgery After Percutaneous Coronary Intervention.2016
Author(s)
Miyagi T, Asaumi Y, Nishimura K, Nakashima T, Sakamoto H, Nakao K, Kanaya T, Nagai T, Shimabukuro Y, Miyamoto Y, Fujita T, Kusano K, Anzai T, Kobayashi J, Noguchi T, Ogawa H, Yasuda S.
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Journal Title
Circ Cardiovasc Interv.
Volume: 9
Related Report
Peer Reviewed
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[Journal Article] Efficacy of urinary midkine as a biomarker in patients with acute kidney injury.2016
Author(s)
Hayashi H, Sato W, Kosugi T, Nishimura K, Sugiyama D, Asano N, Ikematsu S, Komori K, Nishiwaki K, Kadomatsu K, Matsuo S, Maruyama S, Yuzawa Y.
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Journal Title
Clin Exp Nephrol.
Volume: -
NAID
Related Report
Peer Reviewed
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[Journal Article] Donor-transmitted Atherosclerosis Associated with Worsening Cardiac Allograft Vasculopathy After Heart Transplantation: Serial Volumetric Intravascular Ultrasound Analysis.2016
Author(s)
Watanabe T, Seguchi O, Yanase M, Fujita T, Murata Y, Sato T, Sunami H, Nakajima S, Kataoka Y, Nishimura K, Hisamatsu E, Kuroda K, Okada N, Hori Y, Wada K, Hata H, Ishibashi-Ueda H, Miyamoto Y, Fukushima N, Kobayashi J, Nakatani T.
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Journal Title
Transplantation.
Volume: -
Related Report
Peer Reviewed
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[Journal Article] Prognostic significance of endogenous erythropoietin in long-term outcome of patients with acute decompensated heart failure.2016
Author(s)
Nagai T, Nishimura K, Honma T, Higashiyama A, Sugano Y, Nakai M, Honda S, Iwakami N, Okada A, Kawakami S, Kanaya T, Asaumi Y, Aiba T, Nishida Y, Kubota Y, Sugiyama D, Okamura T, Noguchi T, Kusano K, Ogawa H, Yasuda S, Anzai T; NaDEF investigators..
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Journal Title
Eur J Heart Fail.
Volume: 18
Pages: 803-813
Related Report
Peer Reviewed
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[Journal Article] Underweight Young Women Without Later Weight Gain Are at High Risk for Osteopenia After Midlife: The KOBE Study.2016
Author(s)
Tatsumi Y, Higashiyama A, Kubota Y, Sugiyama D, Nishida Y, Hirata T, Kadota A, Nishimura K, Imano H, Miyamatsu N, Miyamoto Y, Okamura T.
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] Prehospital antiplatelet use and functional status on admission of patients with non-haemorrhagic moyamoya disease: a nationwide retrospective cohort study (J-ASPECT study).2016
Author(s)
Onozuka D, Hagihara A, Nishimura K, Kada A, Nakagawara J, Ogasawara K, Ono J, Shiokawa Y, Aruga T, Miyachi S, Nagata I, Toyoda K, Matsuda S, Suzuki A, Kataoka H, Nakamura F, Kamitani S, Nishimura A, Kurogi R, Sayama T, Iihara K; J-ASPECT Study Collaborators..
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Impact of hypertension on the lifetime risk of coronary heart disease.2016
Author(s)
Turin TC, Okamura T, Raheen Afzal A, Rumana N, Watanabe M, Higashiyama A, Nakao YM, Nakai M, Takegami M, Nishimura K, Kokubo Y, Okayama A, Miyamoto Y.
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Journal Title
Hypertens Res.
Volume: 39
Pages: 548-551
Related Report
Peer Reviewed
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[Journal Article] Response to Letter Regarding Article, "Prevalence, Clinical Features, and Prognosis of Acute Myocardial Infarction Attributable to Coronary Artery Embolism".2016
Author(s)
Noguchi T, Yasuda S, Shibata T, Kawakami S, Tanaka T, Asaumi Y, Kanaya T, Nagai T, Nakao K, Fujino M, Nagatsuka K, Ishibashi-Ueda H, Nishimura K, Miyamoto Y, Kusano K, Anzai T, Goto Y, Ogawa H.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Comparison between the triglycerides standardization of routine methods used in Japan and the chromotropic acid reference measurement procedure used by the CDC Lipid Standardization Programme.2016
Author(s)
Nakamura M, Iso H, Kitamura A, Imano H, Noda H, Kiyama M, Sato S, Yamagishi K, Nishimura K, Nakai M, Vesper HW, Teramoto T, Miyamoto Y.
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Journal Title
Ann Clin Biochem.
Volume: 53
Pages: 632-639
Related Report
Peer Reviewed
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[Journal Article] Hypertension and lifetime risk of stroke.2016
Author(s)
Turin TC, Okamura T, Afzal AR, Rumana N, Watanabe M, Higashiyama A, Nakao Y, Nakai M, Takegami M, Nishimura K, Kokubo Y, Okayama A, Miyamoto Y.
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Journal Title
J Hypertens.
Volume: 34
Pages: 116-122
Related Report
Peer Reviewed
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[Journal Article] Suppressive effects of conversion from mycophenolate mofetil to everolimus for the development of cardiac allograft vasculopathy in maintenance of heart transplant recipients.2016
Author(s)
Watanabe T, Seguchi O, Nishimura K, Fujita T, Murata Y, Yanase M, Sato T, Sunami H, Nakajima S, Hisamatsu E, Sato T, Kuroda K, Hieda M, Wada K, Hata H, Ishibashi-Ueda H, Miyamoto Y, Fukushima N, Kobayashi J, Nakatani T.
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Journal Title
Int J Cardiol.
Volume: -
Pages: 307-314
Related Report
Peer Reviewed
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[Journal Article] Calibration between the Estimated Probability of the Risk Assessment Chart of Japan Atherosclerosis Society and Actual Mortality Using External Population: Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN).2016
Author(s)
Nakai M, Miyamoto Y, Higashiyama A, Murakami Y, Nishimura K, Yatsuya H, Saitoh S, Sakata K, Iso H, Miura K, Ueshima H, Okamura T; EPOCH-JAPAN Research Group..
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Journal Title
J Atheroscler Thromb.
Volume: 23
Pages: 176-195
NAID
Related Report
Peer Reviewed
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[Journal Article] Prognostic significance of endogenous erythropoietin in long-term outcome of patients with acute decompensated heart failure.2016
Author(s)
Nagai T, Nishimura K, Honma T, Higashiyama A, Sugano Y, Nakai M, Honda S, Iwakami N, Okada A, Kawakami S, Kanaya T, Asaumi Y, Aiba T, Nishida Y, Kubota Y, Sugiyama D, Okamura T, Noguchi T, Kusano K, Ogawa H, Yasuda S, Anzai T; NaDEF investigators.
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Journal Title
Eur J Heart Fail
Volume: 203
Issue: 7
Pages: 307314-307314
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Calibration between the Estimated Probability of the Risk Assessment Chart of Japan Atherosclerosis Society and Actual Mortality Using External Population: Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN)2016
Author(s)
Nakai M, Miyamoto Y, Higashiyama A, Murakami Y, Nishimura K, Yatsuya H, Saitoh S, Sakata K, Iso H, Miura K, Ueshima H, Okamura T; EPOCH-JAPAN Research Group.
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Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 23
Issue: 2
Pages: 176-195
DOI
NAID
ISSN
1340-3478, 1880-3873
Related Report
Peer Reviewed
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[Journal Article] Prevalence, clinical features, and prognosis of acute myocardial infarction due to coronary artery embolism2015
Author(s)
Noguchi T, Tanaka T, Asaumi Y, Kanaya T, Nagai T, Nakao K, Fujino M, Nagatsuka K, Ishibashi-Ueda H, Nishimura K, Miyamoto Y, Kusano K, Anzai, T, Goto Y, Ogawa H, Yasuda S.
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Journal Title
Circulation
Volume: 132
Issue: 4
Pages: 241-250
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] .Effect of Intensive Statin Therapy on Coronary High-intensity Plaques Detected by Non-contrast T1-Weighted Imaging: the AQUAMARINE Pilot Study.2015
Author(s)
Noguchi T, Tanaka A, Goto Y, Morita Y, Asaumi Y, Nakao Y, Fujiwara R, Nishimura K, Miyamoto Y, Ishhara M, Ogawa H, Koga N, Narula J, Yasuda S.
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Journal Title
J Am Coll Cardiol
Volume: 66
Issue: 3
Pages: 245-256
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Serum Trans-Fatty Acid Concentration Is Elevated in Young Patients With Coronary Artery Disease in Japan2015
Author(s)
Mori K, Ishida T, Yasuda T, Hasokawa M, Monguchi T, Sasaki M, Kondo K, Nakajima H, Shinohara M, Shinke T, Irino Y, Toh R, Nishimura K, Hirata K.
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Journal Title
Circulation Journal
Volume: 79
Issue: 9
Pages: 2017-2025
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed / Open Access
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[Journal Article] Changes in Waist Circumference and the Incidence of Type 2 Diabetes in Community-Dwelling Men and Women: The Suita Study2015
Author(s)
Yukako Tatsumi, Makoto Watanabe, Michikazu Nakai, Yoshihiro Kokubo, Aya Higashiyama, Kunihiro Nishimura, Takashi Kobayashi, Misa Takegami, Yoko M. Nakao, Takuya Watanabe, Akira Okayama, Tomonori Okamura, Yoshihiro Miyamoto
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Journal Title
Journal of Epidemiology
Volume: 25
Issue: 7
Pages: 489-495
DOI
NAID
ISSN
0917-5040, 1349-9092
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Cross-sectional survey of workload and burnout among Japanese physicians working in stroke care: the nationwide survey of acute stroke care capacity for proper designation of comprehensive stroke center in Japan (J-ASPECT) study.2014
Author(s)
Nishimura K, Nakamura F, Takegami M, Fukuhara S, Nakagawara J, Ogasawara K, Ono J, Shiokawa Y, Miyachi S, Nagata I, Toyoda K, Matsuda S, Kataoka H, Miyamoto Y, Kitaoka K, Kada A, Iihara K, Group JAS
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Journal Title
Circulation Cardiovascular quality and outcomes
Volume: 7
Pages: 414-22
Related Report
Peer Reviewed
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[Journal Article] Shiraishi I, Nishimura K, Sakaguchi H, Abe T, Kitano M, Kurosaki K, Kato H, Nakanishi T, Yamagishi H, Sagawa K, Ikeda Y, Morisaki T, Hoashi T, Kagisaki K, Ichikawa H2014
Author(s)
Shiraishi I, Nishimura K, Sakaguchi H, Abe T, Kitano M, Kurosaki K, Kato H, Nakanishi T, Yamagishi H, Sagawa K, Ikeda Y, Morisaki T, Hoashi T, Kagisaki K, Ichikawa H
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Journal Title
Circulation
Volume: 130
Pages: 1053-61
Related Report
Peer Reviewed
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[Journal Article] Serum myeloperoxidase/paraoxonase 1 ratio as potential indicator of dysfunctional high-density lipoprotein and risk stratification in coronary artery disease.2014
Author(s)
Haraguchi Y, Toh R, Hasokawa M, Nakajima H, Honjo T, Otsui K, Mori K, Miyamoto-Sasaki M, Shinohara M, Nishimura K, Ishida T, Hirata K.
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Journal Title
Atherosclerosis
Volume: 234
Pages: 288-94
Related Report
Peer Reviewed
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