Development of molecular-targeting cancer prevention by means of food factors
| Project/Area Number |
26460792
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene and public health
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
YOSHIDA TATSUSHI 京都府立医科大学, 医学(系)研究科(研究院), 講師 (80315936)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 食品成分 / 癌 / 分子標的予防 / TRAIL / RUNX1 / 転写制御 / IRF1 / 脂肪酸代謝産物 / IRF-1 / 転写 / プロモーター / 併用予防 / DR5 / 転写因子 |
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| Outline of Final Research Achievements |
TRAIL is a promising anti-cancer agent but has still been going on clinical studies. To improve the TRAIL efficacy, I carried out the screening of food factors which could induce endogenous TRAIL expression and the analysis of the induction mechanism. Then, I found a marine carotenoid, a flavonoid, an isothiocyanate and a metabolite of fatty acid as TRAIL inducers. In addition, I found two low-molecular weight compounds except for food factors also up-regulated TRAIL expression. I elucidated the mechanism by which the fatty acid metabolite induced TRAIL expression. A transcription factor RUNX1 interacted with IRF1 and collaborated with it to up-regulation of TRAIL expression at the transcription level.
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Report
(4 results)
Research Products
(8 results)
