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Development of molecular-targeting cancer prevention by means of food factors

Research Project

Project/Area Number 26460792
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hygiene and public health
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

YOSHIDA TATSUSHI  京都府立医科大学, 医学(系)研究科(研究院), 講師 (80315936)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords食品成分 / 癌 / 分子標的予防 / TRAIL / RUNX1 / 転写制御 / IRF1 / 脂肪酸代謝産物 / IRF-1 / 転写 / プロモーター / 併用予防 / DR5 / 転写因子
Outline of Final Research Achievements

TRAIL is a promising anti-cancer agent but has still been going on clinical studies. To improve the TRAIL efficacy, I carried out the screening of food factors which could induce endogenous TRAIL expression and the analysis of the induction mechanism. Then, I found a marine carotenoid, a flavonoid, an isothiocyanate and a metabolite of fatty acid as TRAIL inducers. In addition, I found two low-molecular weight compounds except for food factors also up-regulated TRAIL expression. I elucidated the mechanism by which the fatty acid metabolite induced TRAIL expression. A transcription factor RUNX1 interacted with IRF1 and collaborated with it to up-regulation of TRAIL expression at the transcription level.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2016 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (5 results)

  • [Journal Article] 特集「腫瘍の生化学と分子生物学:最新の理解」造血の転写制御と白血病2015

    • Author(s)
      吉田達士、山崎健太、忠垣憲次郎、奥田司
    • Journal Title

      京都府立医科大学雑誌

      Volume: 124 Pages: 797-812

    • Related Report
      2015 Research-status Report
  • [Journal Article] Loss of Runx1/AML1 arginine-methylation impairs in peripheral T cell homeostasis.2015

    • Author(s)
      Mizutani S, Yoshida T, Zhao X, Nimer SD, Taniwaki M, Okuda T.
    • Journal Title

      Br J Haematol.

      Volume: 未定

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Myeloid zinc finger 1 mediates sulindac sulfide-induced upregulation of death receptor 5 of human colon cancer cells.2014

    • Author(s)
      Horinaka M, Yoshida T, Tomosugi M, Yasuda S, Sowa Y, Sakai T.
    • Journal Title

      Scientific Reports

      Volume: 4 Issue: 1 Pages: 6000-6000

    • DOI

      10.1038/srep06000

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Analysis of a transcriptional target gene regulated by RUNX1/AML12016

    • Author(s)
      Tatsushi Yoshida, Yasumichi Kuwahara, Toshiyuki Sakai, Tsukasa Okuda
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2016 Annual Research Report
  • [Presentation] A candidate target gene of RUNX1/AML1 transcription factor2016

    • Author(s)
      Tatsushi Yoshida, Kenjiro Tadagaki, Kenta Yamasaki, Yasumichi Kuwahara, Toshiyuki Sakai, Tsukasa Okuda
    • Organizer
      第78回日本血液学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2016 Annual Research Report
  • [Presentation] RUNX1/AML1はTRAILの転写制御に関与する2016

    • Author(s)
      吉田達士、山崎健太、忠垣憲次郎、桒原康道、酒井敏行、奥田司
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2016 Annual Research Report
  • [Presentation] Myeloid zinc finger 1mediates sulindac sulfide-induced upregulation of death receptor 5 of human colon cancer cells.2015

    • Author(s)
      Mano Horinaka, Tatsushi Yoshida, Yoshihiro Sowa, Toshiyuki Sakai
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] Sulindac sulfideによるMZF1発現調節を介したTRAIL感受性増強2015

    • Author(s)
      堀中真野、吉田達士、曽和義広、酒井敏行
    • Organizer
      第19回日本がん分子標的治療学会
    • Place of Presentation
      松山
    • Year and Date
      2015-06-11
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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