Effects of cruciferous vegetable elements in sensitizer-induced ear edema

• Project/Area Number: 26460795
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Kanazawa University
• Principal Investigator: Tanii Hideji 金沢大学, 医学系, 准教授 (90110618)
• Co-Investigator(Renkei-kenkyūsha): SUGITANI Kayo 金沢大学, 保健学系, 助教 (20162258)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: アリルニトリル / 感作性物質 / 炎症 / 野菜成分 / 活性酸素 / 抗酸化物質 / 感作性化学物質

Outline of Final Research Achievements

There are numerous sensitizers in the environment. It is possible that individuals in the environment are at a risk of exposur to sensitizers. To prevent allergic reactions due to sensitizers, we focused on allyl nitrile derived from cruciferous vegetables. This chemical has the ability to induce antioxidant/phase II detoxification enzymes. Repeated low dose exposure to allyl nitrie decreased sensitizer-induced ear edema, suggesting its capability of reducing allergic reactions. But allyl isothiocyanate showed no anti-allergic reactions. Additionally, isothiocyanates other than allyl isothiocyanate from cruciferous vegetables reportedly decrease dermal allergic reactions.

Research Products

• [Journal Article] Allyl nitrile: Toxicity and health effects (2017)
  • Author(s): Hideji Tanii
  • Journal Title: Journal of Occupational Health Volume: 59 Pages: 104-111
  • NAID: 130005492625
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Anti-inflammatory and antioxidant effects of repeated exposure to cruciferous allyl nitrile in sensitizer-induced ear edema in mice (2016)
  • Author(s): Hideji Tanii, Kayo Sugitani, Kiyofumi Saijoh
  • Journal Title: Medical Science Monitor Basic Research Volume: 22 Pages: 20-26
  • DOI: 10.12659/msmbr.897771
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Can a sensitizer potency be attenuated? (2015)
  • Author(s): 谷井秀治
  • Journal Title: SANGYO EISEIGAKU ZASSHI Volume: 57 Issue: 4 Pages: 144-145
  • DOI: 10.1539/sangyoeisei.wadai15001
  • NAID: 130005093735
  • ISSN: 1341-0725, 1349-533X
  • Peer Reviewed / Open Access
• [Presentation] アリルニトリル：環境からの生成、毒性、健康との関連 (2016)
  • Author(s): 谷井秀治
  • Organizer: シンポジウム「環境と健康」
  • Place of Presentation: 河鹿荘ロイヤルホテル
  • Invited
• [Presentation] 職業アレルギー (2014)
  • Author(s): 谷井秀治、佐藤一博、皆本景子、土橋邦生
  • Organizer: 第19回産業衛生技術専門研修会
  • Place of Presentation: 金沢市文化ホール
  • Year and Date: 2014-09-25