| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
There are numerous sensitizers in the environment. It is possible that individuals in the environment are at a risk of exposur to sensitizers. To prevent allergic reactions due to sensitizers, we focused on allyl nitrile derived from cruciferous vegetables. This chemical has the ability to induce antioxidant/phase II detoxification enzymes. Repeated low dose exposure to allyl nitrie decreased sensitizer-induced ear edema, suggesting its capability of reducing allergic reactions. But allyl isothiocyanate showed no anti-allergic reactions. Additionally, isothiocyanates other than allyl isothiocyanate from cruciferous vegetables reportedly decrease dermal allergic reactions.
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