Methods for the determination of urinary biomarkers of exposure to pesticides
Project/Area Number |
26460799
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hygiene and public health
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Research Institution | Nagoya University |
Principal Investigator |
Ueyama Jun 名古屋大学, 医学系研究科(保健), 准教授 (00397465)
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Co-Investigator(Renkei-kenkyūsha) |
KONDO Takaaki 名古屋大学, 大学院医学系研究科, 教授 (00195900)
KAMIJIMA Michihiro 名古屋市立大学, 大学院医学研究科, 教授 (80281070)
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Research Collaborator |
SAITO Isao 当会コープ商品安全検査センター, 顧問
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 殺虫剤 / 網羅的解析 / ターゲット分析 / 高感度分析 / 職業的殺虫剤曝露 / ネオニコチノイド系殺虫剤 |
Outline of Final Research Achievements |
We have developed the determination method for urinary metabolites of pesticides. Ninety and 74 urine samples have been collected from farmers and the control group, respectively. The numbers of urine samples obtained from pest control operators were 281. We are collecting a lot of urine samples from general population continuously. These samples have been analyzed by metabolome and chemical-target analysis. Five potential biomarkers have been detected at this time. The exposure biomarker for neonicotinoid and pyrethroid exposure were measured from the collected urine samples.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Quantitative analysis of organophosphate insecticide metabolites in urine extracted from disposable diapers of toddlers in Japan2017
Author(s)
Oya N, Ito Y, Hioki K, Asai Y, Aoi A, Sugiura Y, Ueyama J, Oguri T, Kato S, Ebara T, Kamijima M.
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Journal Title
Int J Hyg Environ Health.
Volume: 220
Issue: 2
Pages: 209-216
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Modulation of immunological activity on macrophages induced by diazinon.2017
Author(s)
Ogasawara N, Matsushima M, Kawamura N, Atsumi K, Yamaguchi T, Ochi H, Kusatsugu Y, Oyabu S, Hashimoto N, Hasegawa Y, Ueyama J, Kawabe T.
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Journal Title
Toxicology.
Volume: 379
Pages: 22-30
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Effects of Paraoxonase 1 gene polymorphisms on organophosphate insecticide metabolism in Japanese pest control workers2016
Author(s)
Hirotaka Sato, Yuki Ito, Jun Ueyama, Yuya Kano, Tomoya Arakawa, Masahiro Gotoh, Takaaki Kondo, Yuka Sugiura, Isao Saito, Eiji Shibata, Michihiro Kamijima
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Journal Title
Journal of Occupational Health
Volume: 58
Issue: 1
Pages: 56-65
DOI
NAID
ISSN
1341-9145, 1348-9585
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Exposure characterization of three major insecticide lines in urine of young children in Japan―neonicotinoids, organophosphates, and pyrethroid2016
Author(s)
Aya Osaka, Jun Ueyama, Takaaki Kondo, Hiroshi Nomura, Yuka Sugiura, Isao Saito, Kunihiko Nakane, Ayuko Takaishi, Hiroko Ogi, Shinya Wakusawa, Yuki Ito, Michihiro Kamijima
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Journal Title
Environmental Research
Volume: 147
Pages: 89-96
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] A revised method for determination of dialkylphosphate levels in human urine by solid-phase extraction and liquid chromatography with tandem mass spectrometry: application to human urine samples from Japanese children.2014
Author(s)
Ueyama J, Saito I, Takaishi A, Nomura H, Inoue M, Osaka A, Sugiura Y, Hayashi Y, Wakusawa S, Ogi H, Inuzuka K, Kamijima M, Kondo T.
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Journal Title
Environ Health Prev Med
Volume: 19
Issue: 6
Pages: 405-413
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Contribution of plasma proteins, albumin and alpha 1-acid glycoprotein, to pharmacokinetics of a multi-targeted receptor tyrosine kinase inhibitor, sunitinib, in analbuminemic rats.2014
Author(s)
Toyama Y, Ueyama J, Nomura H, Tsukiyama I, Saito H, Hisada T, Matsuura K, Hasegawa T
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Journal Title
Anticancer Res
Volume: 34
Pages: 2283-2283
Related Report
Peer Reviewed
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[Presentation] Exposure characterization of three major insecticide lines in urine of young children in Japan - neonicotinoids, organophosphates, and pyrethroids2016
Author(s)
Jun Ueyama, Aya Osaka, Takaaki Kondo, Hiroshi Nomura, Yuka Sugiura, Isao Saito, Kunihiko Nakane, Ayuko Takaishi, Hiroko Ogi, Shinya Wakusawa, Yuki Ito, Michihiro Kamijima
Organizer
Conference of international society for environmental epidemiology and international society of exposure science-Asia Chapter 2016
Place of Presentation
札幌
Year and Date
2016-06-26
Related Report
Int'l Joint Research
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[Presentation] Measurement of concentrations of organophosphate insecticide metabolites in urine extracted from used diapers in 1.5-year-old children2016
Author(s)
Naoko Oya, Yuki Ito, Keisuke Hioki, Yuya Asai, Arisa Aoi, Yuka Sugiura, Jun Ueyama, Tomoko Oguri, Sayaka Kato, Takeshi Ebara, Michihiro Kamijima
Organizer
2nd international conference on human biomonitoring
Place of Presentation
ベルリン
Year and Date
2016-04-17
Related Report
Int'l Joint Research
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[Presentation] Interlaboratory and intraindividual variability analysis in measurements of urinary metabolites of organophosphorus insecticides2016
Author(s)
Yuki Ito, Jun Ueyama,Shoji Nakayama, Tomohiko Isobe, Hirotaka Sato, Naoko Oya, Koichi Yoshimasu, Kanami Tsuno, Nozomi Tatsuta, Kunihiko Nakai, Michihiro Kamijima
Organizer
2nd international conference on human biomonitoring
Place of Presentation
ベルリン
Year and Date
2016-04-17
Related Report
Int'l Joint Research
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