Inhibitory co-receptors as new biomarkers for bone marrow transplantation

• Project/Area Number: 26460802
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Yamaguchi University
• Principal Investigator: TAKAHASHI Hidekazu 山口大学, 大学院医学系研究科, 講師 (90450402)
• Co-Investigator(Kenkyū-buntansha): 玉田 耕治 山口大学, 大学院医学系研究科, 教授 (00615841) ; 田邉 剛 (田辺 剛) 山口大学, 大学院医学系研究科, 教授 (80260678)
• Co-Investigator(Renkei-kenkyūsha): TOJO Arinobu 東京大学, 医科学研究所, 教授 (00211681)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 分子疫学 / 免疫学 / 疫学 / 遺伝子 / 遺伝学 / 骨髄移植 / 造血幹細胞移植 / 一塩基多型 / 免疫抑制受容体 / 移植片対宿主病 / コホート研究

Outline of Final Research Achievements

Bone marrow transplantation is a curative therapy for hematological disorders such as leukemia. In unrelated marrow transplantation, matching of HLA genes between donors and recipients has been performed, but the importance of genetic factors other than HLA remains unclear. Recently, the roles of co-receptors and epigenomes in cancer are drawing attention. In this study, polymorphisms of inhibitory co-receptor genes and epigenome related genes (methyltransferase genes) of donors and recipients who received nonrelated bone marrow transplantation were genotyped and tested for association with transplantation outcomes. As a result, no genes were significantly associated the outcomes. A large population with a more homogeneous patient background may be necessary for a definitive conclusion to be made.

Research Products

• [Journal Article] Associations of interactions between NLRP3 SNPs and HLA mismatch with acute and extensive chronic graft-versus-host diseases (2017)
  • Author(s): Hidekazu Takahashi, Naoko Okayama, Natsu Yamaguchi, Yuta Miyahara, Yasuo Morishima, Yutaka Suehiro, Takahiro Yamasaki, Koji Tamada, Satoshi Takahashi, Arinobu Tojo, Shigetaka Asano & Tsuyoshi Tanabe
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 13097-13097
  • DOI: 10.1038/s41598-017-13506-w
  • Peer Reviewed / Open Access
• [Presentation] 非血縁骨髄移植の予後とインフラマソーム遺伝子多型との関連 (2018)
  • Author(s): 髙橋秀和、岡山直子、山口奈津、宮原悠太、MH Mahbub、長谷亮佑、森島泰雄、末廣寛、山﨑隆弘、玉田耕治、高橋聡、東條有伸、浅野茂隆、田邉剛
  • Organizer: 第40回日本造血細胞移植学会総会
• [Remarks] 山口大学大学院医学系研究科 公衆衛生学・予防医学講座
  • URL: http://ds.cc.yamaguchi-u.ac.jp/~dphpm/
• [Remarks] 山口大学 大学院医学系研究科 公衆衛生学・予防医学講座
  • URL: http://ds.cc.yamaguchi-u.ac.jp/~kouei/
• [Remarks] 山口大学 大学院医学系研究科 公衆衛生学・予防医学講座
  • URL: http://www.med.yamaguchi-u.ac.jp/medicine/chair/basic_11.html
• [Remarks] 山口大学大学院医学系研究科境統御健康医学分野
  • URL: http://www.med.yamaguchi-u.ac.jp/medicine/chair/basic_11.html
• [Patent(Industrial Property Rights)] 同種造血幹細胞移植後の予後の予測を補助する方法 (2017)
  • Inventor(s): 髙橋秀和、田邉剛
  • Industrial Property Rights Holder: 山口大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017
  • Overseas
• [Patent(Industrial Property Rights)] 同種造血幹細胞移植後の予後の予測を補助する方法 (2016)
  • Inventor(s): 髙橋秀和、田邉剛
  • Industrial Property Rights Holder: 山口大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-208263
  • Filing Date: 2016-10-25