| Project/Area Number |
26460802
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene and public health
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
玉田 耕治 山口大学, 大学院医学系研究科, 教授 (00615841)
田邉 剛 (田辺 剛) 山口大学, 大学院医学系研究科, 教授 (80260678)
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| Co-Investigator(Renkei-kenkyūsha) |
TOJO Arinobu 東京大学, 医科学研究所, 教授 (00211681)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 分子疫学 / 免疫学 / 疫学 / 遺伝子 / 遺伝学 / 骨髄移植 / 造血幹細胞移植 / 一塩基多型 / 免疫抑制受容体 / 移植片対宿主病 / コホート研究 |
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| Outline of Final Research Achievements |
Bone marrow transplantation is a curative therapy for hematological disorders such as leukemia. In unrelated marrow transplantation, matching of HLA genes between donors and recipients has been performed, but the importance of genetic factors other than HLA remains unclear. Recently, the roles of co-receptors and epigenomes in cancer are drawing attention. In this study, polymorphisms of inhibitory co-receptor genes and epigenome related genes (methyltransferase genes) of donors and recipients who received nonrelated bone marrow transplantation were genotyped and tested for association with transplantation outcomes. As a result, no genes were significantly associated the outcomes. A large population with a more homogeneous patient background may be necessary for a definitive conclusion to be made.
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