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Vibration-induced direct effects and indirect effects: analysis of blood samples collected 25 years ago from patients and acute exposure of healthy subjects to vibration

Research Project

Project/Area Number 26460803
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hygiene and public health
Research InstitutionYamaguchi University

Principal Investigator

HARADA Noriaki  山口大学, その他部局等(医学), 名誉教授 (70116747)

Co-Investigator(Kenkyū-buntansha) Hossain Mahbub (HOSSAIN Mahbub)  山口大学, 大学院医学系研究科, 講師 (80535336)
長谷 亮佑  山口大学, 大学院医学系研究科, 助教 (30711262)
Research Collaborator KAWANO Yoshinao  山口大学, 大学院医学系研究科, 技術補佐員
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords振動障害 / 凍結保存血漿 / 伝達物質 / 急性振動負荷 / 手指血流反応 / 皮膚機械受容器 / 急性手腕振動負荷 / 手腕振動 / 手指振動感覚 / 手指血流 / 機械受容器刺激周波数 / 凍結保存血液 / 急性負荷
Outline of Final Research Achievements

The purpose was to investigate our hypothesis that among workers exposed to vibration, vasodilation of peripheral vessels is induced by vibration-induced direct effects and vasoconstriction, by its indirect effects mediated by autonomic nervous system. Analysis of frozen plasma samples collected 25 years ago from patients with typical vibration syndrome and age-matched healthy controls revealed characteristics of patients with vibration disorders for the biomarkers endothelin-1 and HS-CRP. However, we could not reveal desired results regarding Substance P, CGRP, and vWF due to insufficient precision and mutual interference of relevant ELISA kits. Our investigation on the concomitant changes and response patterns in finger vibrotactile perception and finger blood flow induced by acute exposure of healthy subjects to vibration revealed predominant role of Pacinian mechanoreceptors, and the responses did not follow the changes specified in the international standard ISO 5349-1 (2001).

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2018 2015 2014

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (2 results)

  • [Journal Article] Concomitant Changes and Response Patterns in Finger Vibrotactile Perception and Blood Flow Induced by Acute Exposure to Hand-Am Vibration2018

    • Author(s)
      MH Mahbub, Ryosuke Hase, Natsu Yamaguchi, Hidekazu Takahashi, Yoshinao Kawano, Keiichi Hiroshige, Tsuyoshi Tanabe, Noriaki Harada
    • Journal Title

      Bulletin of Yamaguchi Medical School

      Volume: 65

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A systematic review of diagnostic performance of quantitative tests to assess musculoskeletal disorders in hand-arm vibration syndrome2015

    • Author(s)
      M.H. Mahbub, Y. Kurozawa, T.Ishitake, Y. Kume, K. Miyashita, H. Sakakibara, S. Sato, N. Toibana, N. Harada
    • Journal Title

      Industrial Health

      Volume: 53 Issue: 5 Pages: 391-397

    • DOI

      10.2486/indhealth.2014-0221

    • NAID

      130005101014

    • ISSN
      0019-8366, 1880-8026
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vibration-induced peripheral neuropathy: involvement of fingers and diagnostic performance of vibrotactile perception measurement revisited2015

    • Author(s)
      M.H. Mahbub, T. Ishitake, Y.Kurozawa, T. Takahashi, N. Toibana, R. Hase, Y. Kawano, N. Harada
    • Journal Title

      Proceedings of the 13th international conference on hand-arm vibration, Beijing, China

      Volume: October Pages: 28-29

    • Related Report
      2015 Research-status Report
  • [Journal Article] Analysis of Long-term Stored Plasma Samples for Investigation into the Pathophysiology of Vibration-induced White Finger: Preliminary Results2014

    • Author(s)
      Yoshinao Kawano, Hossain Md. Mahbub, Ryosuke Hase, Tatsuo Sakamoto, Noriaki Harada
    • Journal Title

      Industrial Health

      Volume: 52 Issue: 6 Pages: 548-551

    • DOI

      10.2486/indhealth.2014-0057

    • NAID

      130004687755

    • ISSN
      0019-8366, 1880-8026
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] An investigation into the pathophysiology of vascular injuries in hand-arm vibration syndrome using long-term stored plasma2014

    • Author(s)
      Yoshinao Kawano, Hossain Md. Mahbub, Ryosuke Hase, Mieko Iwamoto, Tatsuo Sakamoto, Noriaki Harada
    • Organizer
      49th UK Conference on Human Responses to Vibration
    • Place of Presentation
      UK Buxton
    • Year and Date
      2014-09-10
    • Related Report
      2014 Research-status Report
  • [Presentation] Investigation into the relationship between hand-arm vibration syndrome and tissue inflammation by analyzing plasma c-reactive protein2014

    • Author(s)
      Ryosuke Hase, Hossain Md. Mahbub, Yoshinao Kawano, Tatsuo Sakamoto, Noriaki Harada
    • Organizer
      49th UK Conference on Human Responses to Vibration
    • Place of Presentation
      UK Buxton
    • Year and Date
      2014-09-10
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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