Elucidation of the ultimate carcinogen associated with occupational cholangiocarcinoma
| Project/Area Number |
26460806
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Hygiene and public health
|
|---|
| Research Institution | The Ohara Memorial Institute for Science of Labour (2015-2016)
Osaka City University (2014) |
|---|
Principal Investigator |
ENDO Ginji 公益財団法人大原記念労働科学研究所, 研究部, 客員研究員 (20160393)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
山中 健三 日本大学, 薬学部, 教授 (50182572)
加藤 孝一 日本大学, 薬学部, 教授 (60246931)
市原 学 東京理科大学, 薬学部薬学科, 教授 (90252238)
|
|---|
| Research Collaborator |
SHIMODA Yasuyo 日本大学, 薬学部, 助教 (70779420)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 胆管がん / 1,2-ジクロロプロパン / ジクロロメタン / ハロゲン化炭化水素 / 化学発がん / グルタチオンS-トランスフェラーゼ / 体細胞突然変異 / 衛生 / 遺伝毒性 |
|---|
| Outline of Final Research Achievements |
The cytotoxicity of 1,2,3-trichloropropane (TCP) is higher than that of 1,2-dichloropropane (DCP). Induction of drug-metabolizing enzymes did not affect toxicity. The mRNA synthesis of GSH-regenerating enzymes is higher than those of CYPs and GSTs in TCP treated cultured cells, suggesting that the metabolic activation by GSH may be deeply involved in the toxicity rather than that by CYPs.
The experiment using human fetal liver-derived cholangiocytes showed that treatment with TNFα increased mRNA level of NFκB and an enzyme related with somatic cell hyper mutation and class switch recombination, suggesting the involvement of this enzyme with mutation of cholangiocytes.
|
Report
(4 results)
Research Products
(26 results)
-
-
-
-
[Journal Article] Investigation of Spatial Clustering of Biliary Tract Cancer Incidence in Osaka, Japan: Neighborhood Effect of a Printing Factory2016
Author(s)
Ito Y, Nakaya T, Ioka A, Nakayama T, Tsukuma H, Uehara S, Sato KK, Endo G, Hayashi T.
-
Journal Title
Journal of Epidemiology
Volume: 26
Issue: 9
Pages: 459-463
DOI
NAID
ISSN
0917-5040, 1349-9092
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Screening and surveillance for occupational cholangiocarcinoma in workers exposed to organic solvents.2016
Author(s)
Kubo S, Takemura S, Tanaka S, Nishioka T, Kinoshita M, Hamano G, Ito T, Yamamoto T, Abue M, Aoki M, Nakagawa K, Hijioka S, Miyamoto A, Osaki Y, Endo G, Kumagai S.
-
Journal Title
Surg Today
Volume: 46
Issue: 6
Pages: 705-712
DOI
NAID
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Role of P450 in Hepatotoxicity and Proliferation in Bile Duct Induced by Exposure to 1,2-Dichloropropane in Mice.2016
Author(s)
Zhang X, Zong C, Zhang L, Garner E, Huang C, Wu W, Chang J, Sakurai T, Ichihara S, Ichihara G.
Organizer
第44回産業中毒・生物学的モニタリング研究会(日本産業衛生学会)
Place of Presentation
東京都
Year and Date
2016-08-04
Related Report
-
[Presentation] 1,2-ジクロロプロパン暴露マウスの肝毒性と胆管細胞の増殖におけるP450の役割.2016
Author(s)
張 驍, Cai ZONG, Lingyi ZHANG, Edwin GARNER, Chinyen HUANG, Wenting WU, Jie CHANG, 桜井 敏博, 市原 佐保子, 市原 学.
Organizer
第43回日本毒性学会学術年会
Place of Presentation
名古屋市
Year and Date
2016-06-29
Related Report
-
-
-
-
-
-
-
-
