Detection of antiviral-resistant influenza viruses
Project/Area Number |
26460816
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hygiene and public health
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Research Institution | National Institute of Infectious Diseases |
Principal Investigator |
Takashita Emi 国立感染症研究所, インフルエンザウイルス研究センター, 主任研究官 (30361249)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 抗インフルエンザ薬 / 薬剤性ウイルス / 薬剤耐性ウイルス |
Outline of Final Research Achievements |
The surveillance of antiviral-resistant viruses is important for public health authorities and clinicians to control influenza. Here, we improved fluorescence-based and chemiluminescence-based neuraminidase (NA) inhibition assays for determining influenza susceptibility to NA inhibitors, oseltamivir, zanamivir, peramivir and laninamivir. Then we established a cell-based screening system to evaluate the susceptibility of influenza viruses to a novel antiviral drug, favipiravir, a viral RNA-dependent RNA polymerase inhibitor.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2014-2015.2016
Author(s)
Hurt AC, Besselaar TG, Daniels RS, Ermetal B, Fry A, Gubareva L, Huang W, Lackenby A, Lee RT, Lo J, Maurer-Stroh S, Nguyen HT, Pereyaslov D, Rebelo-de-Andrade H, Siqueira MM, Takashita E, Tashiro M, Tilmanis D, Wang D, Zhang W, Meijer A.
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Journal Title
Antiviral Res.
Volume: 132
Pages: 178-185
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Influenza A(H1N1)pdm09 virus exhibiting enhanced cross-resistance to oseltamivir and peramivir due to a dual H275Y/G147R substitution, Japan, March 2016.2016
Author(s)
Takashita E, Fujisaki S, Shirakura M, Nakamura K, Kishida N, Kuwahara T, Shimazu Y, Shimomura T, Watanabe S, Odagiri T; Influenza Virus Surveillance Group of Japan.
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Journal Title
Euro Surveill.
Volume: 21
Issue: 24
Pages: 30258-30258
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] TMPRSS2 Independency for Haemagglutinin Cleavage In Vivo Differentiates Influenza B Virus from Influenza A Virus.2016
Author(s)
Sakai K, Ami Y, Nakajima N, Nakajima K, Kitazawa M, Anraku M, Takayama I, Sangsriratanakul N, Komura M, Sato Y, Asanuma H, Takashita E, Komase K, Takehara K, Tashiro M, Hasegawa H, Odagiri T, Takeda M.
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Journal Title
Sci Rep.
Volume: 6
Issue: 1
Pages: 29430-29430
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Characterization of an A (H1N1)pdm09 Virus Imported from India in March 20152016
Author(s)
Takashita E, Fujisaki S, Shirakura M, Nakamura K, Kishida N, Kuwahara T, Ohmiya S, Sato K, Ito H, Chiba F, Nishimura H, Shindo S, Watanabe S, Odagiri T; Influenza Virus Surveillance Group of Japan.
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Journal Title
Japanese Journal of Infectious Diseases
Volume: 69
Issue: 1
Pages: 83-86
DOI
NAID
ISSN
1344-6304, 1884-2836
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2013-2014.2015
Author(s)
Takashita E, Meijer A, Lackenby A, Gubareva L, Rebelo-de-Andrade H, Besselaar T, Fry A, Gregory V, Leang SK, Huang W, Lo J, Pereyaslov D, Siqueira MM, Wang D, Mak GC, Zhang W, Daniels RS, Hurt AC, Tashiro M.
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Journal Title
Antiviral Res.
Volume: 117
Pages: 27-38
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013.2014
Author(s)
Meijer A, Rebelo-de-Andrade H, Correia V, Besselaar T, Drager-Dayal R, Fry A, Gregory V, Gubareva L, Kageyama T, Lackenby A, Lo J, Odagiri T, Pereyaslov D, Siqueira MM, Takashita E, Tashiro M, Wang D, Wong S, Zhang W, Daniels RS, Hurt AC.
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Journal Title
Antiviral Res.
Volume: 110
Pages: 31-41
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 2015/16シーズンに検出されたオセルタミビル・ペラミビルに強い耐性を示すインフルエンザウイルス.2016
Author(s)
高下恵美, 小川理恵, 藤崎誠一郎, 白倉雅之, 三浦秀佳, 中村一哉, 岸田典子, 桑原朋子, 菅原裕美, 佐藤彩, 秋元未来, 渡邉真治, 小田切孝人.
Organizer
第48回日本小児感染症学会
Place of Presentation
岡山
Year and Date
2016-11-19
Related Report
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[Presentation] Detection of influenza A(H1N1)pdm09 viruses exhibiting enhanced cross-resistance to oseltamivir and peramivir in the 2015/16 season.2016
Author(s)
Takashita E, Fujisaki S, Shirakura M, Nakamura K, Kishida N, Kuwahara T, Shimazu Y, Shimomura T, Doi I, Watanabe S, Odagiri T, The Influenza Virus Surveillance Group of Japan.
Organizer
第64回日本ウイルス学会
Place of Presentation
札幌
Year and Date
2016-10-23
Related Report
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[Presentation] Characterization of a Large Cluster of Influenza A(H1N1)pdm09 Virus Cross-Resistant to Oseltamivir and Peramivir during the 2013-2014 Influenza Season in Japan2015
Author(s)
Takashita E, Kiso M, Fujisaki S, Yokohama M, Nakamura K, Shirakura M, Sato H, Odagiri T, Kawaoka Y, Tashino M.
Organizer
4th ISIRV-AVG Conference
Place of Presentation
University of Texas at Austin (Texas, USA)
Year and Date
2015-06-02
Related Report
Int'l Joint Research
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[Presentation] A community cluster of influenza A(H1N1)pdm09 virus exhibiting cross-resistance to oseltamivir and peramivir in Japan, November 2013 to February 20142014
Author(s)
E Takashita, M Ejima, S Fujisaki, M Yokoyama, K Nakamura, M Shirakura, H Sugawara, A Sato, H Sato, M Tashiro, T Odagiri
Organizer
5th ESWI Influenza Conference
Place of Presentation
Radisson Blu Hotel Latvija (Riga, Latvia)
Year and Date
2014-09-14 – 2014-09-17
Related Report
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