| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
The urinary excretion kinetics of the metabolites of a pyrethroid metofluthrin was examined in rats. Urinary 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl alcohol was considered to be an optimal biomarker for monitoring metofluthrin exposure. Analytical methods were developed for determination of urinary metabolites of pyrethroids and phthalates.
In a survey on indoor exposure to insecticides, plasticizers and flame-retardants in children, the urine samples were collected from 132 children with air samples from their bedrooms. The indoor air contamination was demonstrated by measuring these compounds in the air samples. It is examined the amounts of the compounds absorbed in the children by measurement of their metabolites in the urine samples, and evaluated effects of indoor air quality on internal contamination by the compounds in the children.
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