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Eicosapentaenoic Acid/Arachidonic Acid Ratio and Insulin Resistance in Japanese Junior High School Students

Research Project

Project/Area Number 26460847
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hygiene and public health
Research InstitutionJikei University School of Medicine

Principal Investigator

Nishimura Rimei  東京慈恵会医科大学, 医学部, 准教授 (20343535)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords脂肪酸分画 / インスリン抵抗性 / 小児 / 肥満 / 疫学 / 生活習慣
Outline of Final Research Achievements

The eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio in adults is known to be an independent risk factor for cardiovascular disease. However, very few reports are available on the EPA/AA ratio in Asian children. An epidemiological study was conducted to investigate the EPA/AA ratio and insulin resistance in 175 (115 boys and 60 girls) ninth-graders in Tsunan Town, Niigata Prefecture in Japan.
The medians and interquartile ranges in the participants were as follows: EPA/AA ratio, 0.13 (0.09-0.16) and HOMA-IR, 1.7 (1.4-2.2). EPA/AA ratio was not significantly different between the boys and girls at 0.12 (0.09-0.16) and 0.13 (0.09-0.16) (P = 0.375). There was no significant correlation between EPA/AA ratio and HOMA-IR. The present study appears to suggest that EPA levels are likely to be high not only in adults but in adolescents in East Asia.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Population-based cross-sectional study on insulin resistance and insulin-secretory capacity in Japanese school children.2017

    • Author(s)
      Nishimura R, Sano H, Onda Y, Tsujino D, Ando K, Ebara F, Matsudaira T, Ishikawa S, Sakamoto T, Tajima N, Utsunomiya K.
    • Journal Title

      J Diabetes Investig.

      Volume: Epub ahead of print Issue: 5 Pages: 672-676

    • DOI

      10.1111/jdi.12637

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

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