Development of a Reasoning System for Pharmacodynamic Mechanism of Adverse Drug Reaction Based on Ontology

Research Project

Project/Area Number	26460857
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Medical and hospital managemen
Research Institution	The University of Tokyo
Principal Investigator	Imai Takeshi 東京大学, 大学院医学系研究科(医学部), 准教授 (90401075)
Research Collaborator	Hayakawa Masayo 国立がん研究センター, がん情報提供部 Ohe Kazuhiko 東京大学, 大学院医学系研究科, 教授
Project Period (FY)	2014-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	オントロジー / 知識推論 / 薬物有害事象 / 薬力学 / 医薬品副作用
Outline of Final Research Achievements	This study aimed to develop a reasoning system for pharmacodynamic mechanism of adverse drug reaction. We first developed pharmacodynamics ontology which represents causal chains between drug, target, and physiological states. Then we constructed a reasoning system for pharmacodynamic mechanism of adverse drug reaction related to dysuria by traversing the ontology. We also evaluated the system by comparing the inferred results with the known adverse events derived from the drug package inserts and the actual adverse event cases.