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Development of a Reasoning System for Pharmacodynamic Mechanism of Adverse Drug Reaction Based on Ontology

Research Project

Project/Area Number 26460857
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical and hospital managemen
Research InstitutionThe University of Tokyo

Principal Investigator

Imai Takeshi  東京大学, 大学院医学系研究科(医学部), 准教授 (90401075)

Research Collaborator Hayakawa Masayo  国立がん研究センター, がん情報提供部
Ohe Kazuhiko  東京大学, 大学院医学系研究科, 教授
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsオントロジー / 知識推論 / 薬物有害事象 / 薬力学 / 医薬品副作用
Outline of Final Research Achievements

This study aimed to develop a reasoning system for pharmacodynamic mechanism of adverse drug reaction. We first developed pharmacodynamics ontology which represents causal chains between drug, target, and physiological states. Then we constructed a reasoning system for pharmacodynamic mechanism of adverse drug reaction related to dysuria by traversing the ontology. We also evaluated the system by comparing the inferred results with the known adverse events derived from the drug package inserts and the actual adverse event cases.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2016

All Presentation (1 results)

  • [Presentation] 臨床医学オントロジーにおける異常状態と診療情報との自動マッピングに向けた基礎的検討2016

    • Author(s)
      今井健, 林亜紀, 桜井亮太, Xiaojun Ma, 篠原恵美子, 古崎晃司, 大江和彦
    • Organizer
      第30回人工知能学会全国大会
    • Place of Presentation
      北九州国際会議場
    • Year and Date
      2016-06-06
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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