Rapid drug screening system for death investigation
| Project/Area Number |
26460873
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
Usui Kiyotaka 東北大学, 医学系研究科, 講師 (80567884)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Flow injection / QuEChERS extraction / Drug screening / Tandem mass spectrometry / フローインジェクション分析 / QuEChERS / 質量分析 / 薬毒物分析 / 質量分析計 |
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| Outline of Final Research Achievements |
There is a compelling need for the rapid drug screening in forensic science in Japan. From the start-up of an LC-MS/MS to the reporting of the result, including analysis of the blank sample, a period of more than 2 hours is typical. Additionally, this technique is somewhat difficult for less experienced analysts. Therefore, we addressed these limiting factors by developing a reliable and simple analytical technique using a combination of the QuEChERS method and an FI-MS/MS, which returns results within 10 min. This new method enabled us to complete the entire drug screening process within 10 min. For actual forensic cases, the qualitative results roughly matched (96% concordance rate) with the results obtained with the standard LC-MS/MS technique. Although some drugs present at low concentrations were not detected in the analysis of forensic cases, the QuEChERS-FI-MS/MS method was able to detect a wide-range of drugs in whole blood in a relatively short time.
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Report
(4 results)
Research Products
(11 results)
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[Presentation] Rapid Drug Screening Using a Combination of Flow Injection Tandem Mass Spectrometry (FI/MS/MS) and the Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) Method2015
Author(s)
Kiyotaka Usui, Koichi Saito, Tetsuo Kokaji, Tomomi Aramaki, Masato Funayama
Organizer
American Academy of Forensic Sciences
Place of Presentation
USA, Orlando
Year and Date
2015-02-16 – 2015-02-21
Related Report
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[Presentation] 急性薬物中毒における迅速診断法の開発2014
Author(s)
臼井聖尊、小梶哲雄、齋藤弘一、荒牧友美、舟山眞人
Organizer
日本法中毒学会 第33年会
Place of Presentation
名古屋（名古屋大学シンポジオンホール）
Year and Date
2014-07-04 – 2014-07-05
Related Report
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