| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Outline of Final Research Achievements |
The frequency and distribution of unruptured cerebral aneurysms of minimal size in forensic autopsy cases were analyzed, measuring the activities of galatinases in cerebrospinal fluid(CSF). The results showed that gelatinolytic activities of CSF generated from gelatinase A and B can serve as good markers of early-stage cerebral aneurysm（p<0.001）. Moreover the gelatinolytic activities of CSF demonstrated parallels with the concentration of α-Klotho protein by which Ca deposition is controlled locally in the body. Therefore, combined with the microscopic findings, these Ca-dependent biochemical values of CSF can help to predict the development of cerebral aneurysms.
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