Analysis of vascular tissue fragility of cerebral arteries affected by cerebrospinal fluid.
Project/Area Number |
26460874
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Legal medicine
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Research Institution | Kanazawa University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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Keywords | 脳動脈瘤 / プロテアーゼ / 脳脊髄液 / カルシウム / α-Klotho蛋白 / 未破裂小動脈瘤 / マトリックスメタロプロテアーゼ / 組織脆弱性 |
Outline of Final Research Achievements |
The frequency and distribution of unruptured cerebral aneurysms of minimal size in forensic autopsy cases were analyzed, measuring the activities of galatinases in cerebrospinal fluid(CSF). The results showed that gelatinolytic activities of CSF generated from gelatinase A and B can serve as good markers of early-stage cerebral aneurysm(p<0.001). Moreover the gelatinolytic activities of CSF demonstrated parallels with the concentration of α-Klotho protein by which Ca deposition is controlled locally in the body. Therefore, combined with the microscopic findings, these Ca-dependent biochemical values of CSF can help to predict the development of cerebral aneurysms.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Activated tumor cell integrin αvβ3 cooperates with platelets to promote extravasation and metastasis from the blood stream.2016
Author(s)
Weber MR, Zuka M, Lorger M, Tschan M, Torbett BE, Zijlstra A, Quigley JP, Staflin K, Eliceiri BP, Krueger JS, Marchese P, Ruggeri ZM, Felding BH.
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Journal Title
Thrombosis Research
Volume: 140 Suppl 1
Pages: S27-S36
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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