Infection-induced renal impairment in a chronic liver disease mouse model
Project/Area Number |
26460877
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Legal medicine
|
Research Institution | Kyoto University |
Principal Investigator |
|
Research Collaborator |
TAMAKI Keiji
MIYAO Masashi
ISHIDA Tokiko
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 慢性肝障害 / 腎障害 / ミトコンドリア障害 / オートファジー / 酸化ストレス / sublethal cell injury |
Outline of Final Research Achievements |
We performed a pathophysiological study of renal injuries in a model mouse of chronic liver disease induced by a drug. The kidney of this model showed acute kidney injury with sublethal tubular cell injury and developed resistance for drug- or infection-induced renal impairment by physiological mechanisms including autophagy. This chronic liver disease model showing acute kidney injury with sublethal injury is a potentially useful tool for the study of pathophysiological mechanisms to develop resistance for renal impairment in patients with chronic liver disease, and could lead to the development of novel therapeutic and protective strategies to improve the prognosis of patients with infectious complications.
|
Report
(4 results)
Research Products
(3 results)