| Project/Area Number |
26460887
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Kitasato University (2016)
Tokai University (2014-2015) |
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Principal Investigator |
Satoh Fumiko 北里大学, 医学部, 教授 (70328128)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 動脈石灰化 / 粥状硬化症 / 急性大動脈解離 / 大動脈瘤 / 動脈硬化症 / 急性動脈解離 / 法医解剖 / intimal tear / 心肥大 / 高血圧症 / DeBakey 分類 / AHA分類 / 免疫組織化学 / AHSG / MMPｓ / MGP |
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| Outline of Final Research Achievements |
We tried to establish a histologic method of arterial calcification. We produced a specimen for a strong part of aortic calcification obtained through forensic autopsy and classified areas roughly as 1) diffuse calcification, 2) tininess calcification, 3) diffuse calcification of endosporium, or 4) ossification or myelogenesis. We examined the histology of the intimal tear site of the acute aortic dissection case and the aorta histology of the control case. For both, we semiquantified on cystic medial necrosis, elastin fragmentation, fibrosis, and medionecrosis. Results show that advanced atherosclerosis and weakness of media by calcification have an undeniable relation to the onset of aortic dissection and aortic aneurysms.
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