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Investigation on the piruitary glands in cases of suicide

Research Project

Project/Area Number 26460892
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Legal medicine
Research InstitutionKyorin University (2015-2016)
Kanazawa Medical University (2014)

Principal Investigator

OH RO  杏林大学, 医学部, 准教授 (60555051)

Co-Investigator(Kenkyū-buntansha) 北村 修  杏林大学, 医学部, 教授 (70266609)
武市 敏明  金沢大学, 医学系, 助教 (90460360)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords自殺 / 下垂体病変 / HPA axis / 免疫組織化学的染色 / HPA axis / 免疫組織化学染色 / HPA axis / 免疫組織学的染色 / 下垂体
Outline of Final Research Achievements

In this study, an association between suicide and pituitary disease was examined by assessing pituitary disease in a suicidal group to be subjected to forensic autopsy histopathologically.
Hematoxylin and eosin stain and immunohistological staining using antibodies against anterior pituitary gland hormone were performed for pituitary gland obtained from 73 suicidal group and 224 non-suicidal group. As a result, pituitary disease was found in 59% of the suicidal group and 32% of the non-suicidal group, which clearly indicated that pituitary disease constituted a significant proportion in the suicidal group. In the suicidal group, the most common disease was adenoma, followed by pustular disease (e.g., Rathke cysts), and tumor other than adenoma. Given the above, it is noted that morphologic changes of the pituitary gland may be a risk factor of suicide.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2016 2015

All Presentation (3 results)

  • [Presentation] 自殺剖検例における下垂体の検討:Rathke嚢胞による前葉細胞の病理学的変化2016

    • Author(s)
      王 路、武市 敏明、高木 徹也、高篠 智、吉田 昌記、山田千歩、氣賀澤秀明、岩楯桜子、髙橋かすみ、北村 修
    • Organizer
      第100次日本法医学会学術全国集会
    • Place of Presentation
      きゅりあん(品川区総合区民センター)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 自殺例における下垂体の病理組織学的検討2015

    • Author(s)
      王路、武市敏明、北村修
    • Organizer
      第99次日本法医学会学術全国集会
    • Place of Presentation
      高知市文化プラザホール
    • Year and Date
      2015-06-12
    • Related Report
      2015 Research-status Report
  • [Presentation] 自殺例における下垂体疾患2015

    • Author(s)
      北村 修
    • Organizer
      金沢医科大学平成25年度戦略プロジェクト研究発表会
    • Place of Presentation
      金沢医科大学
    • Year and Date
      2015-04-25
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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