| Project/Area Number |
26460893
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Kawasaki University of Medical Welfare |
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Principal Investigator |
MORIYA Fumio 川崎医療福祉大学, 医療福祉学部, 教授 (40182274)
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| Co-Investigator(Kenkyū-buntansha) |
宮石 智 岡山大学, 医歯薬学総合研究科, 教授 (90239343)
吉留 敬 川崎医科大学, 医学部, 講師 (40304307)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 社会医学 / 法中毒学 / 静脈内投与薬物 / 塩基性薬物 / メタンフェタミン / 胃内排泄 / 動物実験モデル / ガスクロマトグラフ-質量分析法 / 薬物分析 / 静脈内投与 / ガスクロマトグラフィー / 塩基性代謝物 / 尿中濃度 |
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| Outline of Final Research Achievements |
Our analytical findings on drugs in forensic autopsy cases demonstrated that: (1) basic drugs such as methamphetamine and ephedrine that are excreted into urine as unmetabolized form into urine at a large proportion appear at a higher concentration in urine than in the stomach when administered intravenously, and basic drugs that are mostly excreted into urine as metabolized form appear at a higher concentration in the stomach than in urine after intravenous administration; and (2) metabolites of a basic drug which increase gradually in blood are rapidly excreted into the stomach if they preserve basic character.
An animal experiment using rabbits demonstrated that flecainide, a basic drug, is rapidly excreted into the stomach when it is intravenously administered. We established an animal model using rats for investigating excretion patterns of methamphetamine into the stomach.
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