| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Outline of Final Research Achievements |
Haptoglobin (HP) is produced by the liver and it bind to free hemoglobin to prevent the loss of hemoglobin and neutralize the adverse physiologic effects of it. It is known that the serum HP concentration is influenced not only by various diseases or physical conditions but individual variability. In this study, we performed association study on various populations to explain the individual variability. Accordingly, 2 SNPs, rs5472 and rs2000999, and HP deletion allele, HPdel, independently influenced the serum HP concentration. In addition, we estimated the generation time of the HPdel by sequence analysis of the region flanking the junctions to be relatively recent because no substations in the analyzed sequence.
|
