Searching of genetic polymorphisms affecting the serum haptoglobin concentration.
| Project/Area Number |
26460894
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Kurume University |
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Principal Investigator |
Koda Yoshiro 久留米大学, 医学部, 教授 (90231307)
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| Co-Investigator(Kenkyū-buntansha) |
副島 美貴子 久留米大学, 医学部, 講師 (80279140)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ハプトグロビン / 血中濃度 / 遺伝子多型 / 関連解析 / アリルの生成年代 / 遺伝子欠失 / 個人差 |
|---|
| Outline of Final Research Achievements |
Haptoglobin (HP) is produced by the liver and it bind to free hemoglobin to prevent the loss of hemoglobin and neutralize the adverse physiologic effects of it. It is known that the serum HP concentration is influenced not only by various diseases or physical conditions but individual variability. In this study, we performed association study on various populations to explain the individual variability. Accordingly, 2 SNPs, rs5472 and rs2000999, and HP deletion allele, HPdel, independently influenced the serum HP concentration. In addition, we estimated the generation time of the HPdel by sequence analysis of the region flanking the junctions to be relatively recent because no substations in the analyzed sequence.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Corneodesmosin gene deletion is prevalent in Japanese patients with peeling skin disease: identification of 2 new cases.2016
Author(s)
Teye K, Suga Y, Numata S, Ishii N, Krol RP, Ohata C, Matsuda M, Honma M, Ishida-Yamamoto A, Hamada T, Hashimoto T.
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Journal Title
Journal of Dermatological Science
Volume: 82
Issue: 2
Pages: 134-137
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Haptoglobin promoter polymorphism rs5472 as a prognostic biomarker for peptide vaccine efficacy in castration-resistant prostate cancer patients.2015
Author(s)
Araki H, Pang X, Komatsu N, Soejima M, Miyata N, Takaki M, Muta S, Sasada T, Noguchi M, Koda Y, Itoh K, Kuhara S, Tashiro K.
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Journal Title
Cancer Immunol Immunother.
Volume: 64
Issue: 12
Pages: 1565-1573
DOI
Related Report
Peer Reviewed
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[Journal Article] Haptoglobin genotyping of Vietnamese: global distribution of HPdel, complete deletion allele of the HP gene.2015
Author(s)
Soejima M, Agusa T, Iwata H, Fujihara J, Kunito T, Takeshita H, Lan VT, Minh TB, Takahashi S, Trang PT, Viet PH, Tanabe S, Koda Y.
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Journal Title
Legal Medicine
Volume: 17
Issue: 1
Pages: 14-16
DOI
Related Report
Peer Reviewed
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