Role of pregnane X receptor in the preventive effect of Boiogito against experimentally induced cholestatic liver injury
| Project/Area Number |
26460903
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | University of Toyama |
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Principal Investigator |
Watanabe Shiro 富山大学, 和漢医薬学総合研究所, 准教授 (00222406)
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| Co-Investigator(Kenkyū-buntansha) |
藤田 恭輔 富山大学, 和漢医薬学総合研究所, 助教 (70707538)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 胆汁酸 / トランスポーター / 水酸化 / 硫酸抱合化 / CAR / VDR / 核内受容体 / FXR / 胆汁うっ滞性肝疾患 / リトコール酸 / 肝臓 / 小腸 / 吸収 / 排泄 / 代謝 / cyp3a11 / BSEP / MRP3 / OSTβ |
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| Outline of Final Research Achievements |
Lithocholic acid (LCA) was orally given to mice to induce cholestatic liver injury. The co-administration of Boiogito (BOT) with LCA was shown to ameliorate LCA-induced liver injury and cholestasis. These effects were associated with the attenuation of the elevation in hepatic content of LCA. BOT administration could increase the expression levels of mRNA as well as proteins of cytochrome P450 2b10 (Cyp2b10) and sulfotransferase 2a1 (sult2a1) in liver. These results suggest that BOT can prevent cholestasis through the acceleration of the degradation of LCA in liver. The induction of the above bile acid metabolizing enzymes is known to be mediated by the activation of a set of several nuclear receptors such as pregnane X receptor (PXR), constitutive androstane receptor (CAR) as well as vitamin D receptor (VDR). Further studies are necessary to explore the role of these receptors in the preventive effect of BOT on LCA-induced cholestatic liver injury.
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Report
(4 results)
Research Products
(23 results)
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[Presentation] 大柴胡湯の抗肥満作用の検討2014
Author(s)
林忠紘、荒哲也、和田篤敬、藤田恭輔、渡辺志朗
Organizer
日本生薬学会第61年会
Place of Presentation
福岡
Year and Date
2014-09-13 – 2014-09-14
Related Report
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