| Project/Area Number |
26460908
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Ehime University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Sumiyoshi Maho 愛媛大学, 大学院医学系研究科, 助教 (60444767)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 癌 / 植物成分 / 薬理学 / 生理活性 / 生体分子 |
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| Outline of Final Research Achievements |
It is suggested that the antitumor and antimetastatic actions of esculetin (6,7-dihydroxycourmarin) among dihydroxycoumarins may be due to the regulated activation of tumor-associated macrophage (TAM) by M2 macrophage differentiation (inhibition of phosphorylation of Stat3) in the tumor microenvironment and/or G1 arrest in tumor cells. Xanthangelol and 4-hydroxyderricin isolated from Angelica keiskei root might be also attributed to the regulated activated TAM through the inhibition of activation (monocyte chemoattractant protein-1 production) and differentiation (inhibition of phosphorylation of Stat3) of M2 macrophages in the tumor microenvironment. The antitumor and antimetastaic action to lung by resveratrol (3,4’,5-trihydroxystilbene) and the related synthetic dihydroxystilbenes (2,3-, 3,5- and 4,4’-dihydroxystilbene) were partly due to antilymphangiogenesis through the regulation of M2 macrophage activation and differentiation in TAMs.
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