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Antitumor activities of various natural compounds isolated from medicinal plants through the regulation of tumor environment, and those mechanisms

Research Project

Project/Area Number 26460908
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionEhime University

Principal Investigator

Kimura Yoshiyuki  愛媛大学, 医学系研究科, 講師 (20294796)

Co-Investigator(Renkei-kenkyūsha) Sumiyoshi Maho  愛媛大学, 大学院医学系研究科, 助教 (60444767)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords癌 / 植物成分 / 薬理学 / 生理活性 / 生体分子
Outline of Final Research Achievements

It is suggested that the antitumor and antimetastatic actions of esculetin (6,7-dihydroxycourmarin) among dihydroxycoumarins may be due to the regulated activation of tumor-associated macrophage (TAM) by M2 macrophage differentiation (inhibition of phosphorylation of Stat3) in the tumor microenvironment and/or G1 arrest in tumor cells. Xanthangelol and 4-hydroxyderricin isolated from Angelica keiskei root might be also attributed to the regulated activated TAM through the inhibition of activation (monocyte chemoattractant protein-1 production) and differentiation (inhibition of phosphorylation of Stat3) of M2 macrophages in the tumor microenvironment. The antitumor and antimetastaic action to lung by resveratrol (3,4’,5-trihydroxystilbene) and the related synthetic dihydroxystilbenes (2,3-, 3,5- and 4,4’-dihydroxystilbene) were partly due to antilymphangiogenesis through the regulation of M2 macrophage activation and differentiation in TAMs.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2016 2015

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 2 results,  Acknowledgement Compliant: 6 results)

  • [Journal Article] Antitumor and Antimetastatic Activity of Synthetic Hydroxystilbenes Through Inhibition of Lymphangiogenesis and M2 Macrophage Differentiation of Tumor-associated Macrophages2016

    • Author(s)
      Yoshiyuki Kimura, Maho Sumiyoshi, Kimiye Baba
    • Journal Title

      Anticancer Research

      Volume: 36 Pages: 137-148

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Resveratrol Prevents Tumor Growth and Metastasis by Inhibiting Lymphangiogenesis and M2 Macrophage Activation and Differentiation in Tumor-associated Macrophages2016

    • Author(s)
      Yoshiyuki Kimura, Maho Sumiyoshi
    • Journal Title

      Nutrition and Cancer

      Volume: 68 Issue: 4 Pages: 667-678

    • DOI

      10.1080/01635581.2016.1158295

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effects of a High-Fat or High-Sucrose Diet on Ultraviolet B irradiation-Induced Carcinogenesis and Tumor Growth in Melanin-Possessing Hairless Mice2016

    • Author(s)
      Maho Sumiyoshi, Yoshiyuki Kimura
    • Journal Title

      Nutrition and Cancer

      Volume: 68 Pages: 791-803

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Antitumor and Antimetastatic Activity of Synthetic Hydroxystilbenes Through Inhibition of Lymphangiogenesis and M2 Macrophage Differentiation of Tumor-associated Macrophages2016

    • Author(s)
      Yoshiyuki Kimura, Maho Sumiyoshi, Kimiye Baba
    • Journal Title

      Anticancer Research

      Volume: 36 Pages: 137-148

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Antitumor and antimetastatic actions of xanthoangelol and 4-hydroxyderricin isolated from Angelica keiskei roots through the inhibited activation and differentiation of M2 macrophages2015

    • Author(s)
      Maho Sumiyoshi, Masahiko Taniguchi, Kimiye Baba, Yoshiyuki Kimura
    • Journal Title

      Phytomedicine

      Volume: 22 Issue: 7-8 Pages: 759-767

    • DOI

      10.1016/j.phymed.2015.05.005

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Antitumor and antimetastatic actions of dihydroxycoumarins (esculetin or fraxetin) through the inhibition of M2 macrophage differentiation in tumor-associated macrophages and/or G1 arrest in tumor cells2015

    • Author(s)
      Yoshiyuki Kimura, Maho Sumiyoshi
    • Journal Title

      European Journal of Pharmacology

      Volume: 746 Pages: 115-125

    • DOI

      10.1016/j.ejphar.2014.10.048

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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